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McIntosh, J, Lenting, PJ, Rosales, C, Lee, D, Rabbanian, S, Raj, D, Patel, N, Tuddenham, EGD, Christophe, OD, McVey, JH, Waddington, S, Nienhuis, AW, Gray, JT, Fagone, P, Mingozzi, F, Zhou, S-Z, High, KA, Cancio, M, Ng, CYC, Zhou, J, Morton, CL, Davidoff, AM and Nathwani, AC (2013) Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant BLOOD, 121 (17). pp. 3335-3344.

Binny, C, McIntosh, J, Della Peruta, M, Kymalainen, H, Tuddenham, EG, Buckley, SM, Waddington, SN, McVey, JH, Spence, Y, Morton, CL, Thrasher, AJ, Gray, JT, Castellino, FJ, Tarantal, AF, Davidoff, AM and Nathwani, AC (2012) AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage. Blood, 119 (4). pp. 957-966.

Ward, NJ, Buckley, SM, Waddington, SN, Vandendriessche, T, Chuah, MK, Nathwani, AC, McIntosh, J, Tuddenham, EG, Kinnon, C, Thrasher, AJ and McVey, JH (2011) Codon optimization of human factor VIII cDNAs leads to high-level expression. Blood, 117 (3). pp. 798-807.

Chen, D, Weber, M, Shiels, PG, Dong, R, Webster, Z, Mcvey, JH, Kemball-Cook, G, Tuddenham, EGD, Lechler, RI and Dorling, A (2006) Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 4 (10). pp. 2191-2198.

Gomez, K, McVey, JH and Tuddenham, E (2005) Inhibition of coagulation by macromolecular complexes HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 90 (11). pp. 1570-1576.

Albrecht, C, McVey, JH, Elliott, JI, Sardini, A, Kasza, I, Mumford, AD, Naoumova, RP, Tuddenham, EGD, Szabo, K and Higgins, CF (2005) A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a patient with Scott syndrome BLOOD, 106 (2). pp. 542-549.

McVey, JH, Lal, K, Imanaka, Y, Kemball-Cook, G, Bolton-Maggs, PH and Tuddenham, EG (2005) Characterisation of blood coagulation factor XI T475I. Thromb Haemost, 93 (6). pp. 1082-1088.

Chen, DX, Weber, M, McVey, JH, Kemball-Cook, G, Tuddenham, EGD, Lechler, RI and Dorling, A (2004) Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium AMERICAN JOURNAL OF TRANSPLANTATION, 4 (12). pp. 1958-1963.

Chen, DX, Giannopoulos, K, Shiels, PG, Webster, Z, McVey, JH, Kemball-Cook, G, Tuddenham, E, Moore, M, Lechler, R and Dorling, A (2004) Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium BLOOD, 104 (5). pp. 1344-1349.

Gomez, K, Laffan, MA, Kemball-Cook, G, Pasi, J, Layton, M, Singer, JD, Tuddenham, EGD and McVey, JH (2004) Two novel mutations in severe factor VII deficiency BRITISH JOURNAL OF HAEMATOLOGY, 126 (1). pp. 105-110.

Steen, M, Norstrom, EA, Tholander, AL, Bolton-Maggs, PHB, Mumford, A, McVey, JH, Tuddenham, EGD and Dahlback, B (2004) Functional characterization of factor V-Ile359Thr: a novel mutation associated with thrombosis BLOOD, 103 (9). pp. 3381-3387.

Elliott, JI, Mumford, AD, Albrecht, C, Collins, PW, Giddings, JC, Higgins, CF, Tuddenham, EGD and McVey, JH (2004) Characterisation of lymphocyte responses to Ca2+ in Scott syndrome THROMBOSIS AND HAEMOSTASIS, 91 (2). pp. 412-415.

Mumford, AD, McVey, JH, Morse, CV, Gomez, K, Steen, M, Norstrom, EA, Tuddenham, EGD, Dahlback, B and Bolton-Maggs, PHB (2003) Factor VI359T: a novel mutation associated with thrombosis and resistance to activated protein C BRITISH JOURNAL OF HAEMATOLOGY, 123 (3). pp. 496-501.

Bachli, EB, Pech, CM, Johnson, KM, Johnson, DJD, Tuddenham, EGD and McVey, JH (2003) Factor Xa and thrombin, but not factor VIIa, elicit specific cellular responses in dermal fibroblasts JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 1 (9). pp. 1935-1944.

Davidson, CJ, Tuddenham, EG and McVey, JH (2003) 450 million years of hemostasis JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 1 (7). pp. 1487-1494.

Zhang, B, Cunningham, MA, Nichols, WC, Bernat, JA, Seligsohn, U, Pipe, SW, McVey, JH, Schulte-Overberg, U, de Bosch, NB, Ruiz-Saez, A, White, GC, Tuddenham, EGD, Kaufman, RJ and Ginsburg, D (2003) Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex NATURE GENETICS, 34 (2). pp. 220-225.

Davidson, CJ, Hirt, RP, Lal, K, Snell, P, Elgar, G, Tuddenham, EGD and McVey, JH (2003) Molecular evolution of the vertebrate blood coagulation network THROMBOSIS AND HAEMOSTASIS, 89 (3). pp. 420-428.

David, D, Santos, IMA, Johnson, K, Tuddenham, EGD and McVey, JH (2003) Analysis of the consequences of premature termination codons within factor VIII coding sequences JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 1 (1). pp. 139-146.

Chen, DX, Riesbeck, K, McVey, JH, Kemball-Cook, G, Tuddenham, EGD, Lechler, RI and Dorling, A (2001) Human thrombin and FXa mediate porcine endothelial cell activation; modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins XENOTRANSPLANTATION, 8 (4). pp. 258-265.

David, D, Saenko, EL, Santos, IMA, Johnson, DJD, Tuddenham, EGD, McVey, JH and Kemball-Cook, G (2001) Stable recombinant expression and characterization of the two haemophilic factor VIII variants C329S (CRM-) and G1948D (CRMr) BRITISH JOURNAL OF HAEMATOLOGY, 113 (3). pp. 604-615.

McVey, JH, Boswell, E, Mumford, AD, Kemball-Cook, G and Tuddenham, EGD (2001) Factor VII deficiency and the FVII mutation database HUMAN MUTATION, 17 (1). pp. 3-17.

Millar, DS, Kemball-Cook, G, McVey, JH, Tuddenham, EGD, Mumford, AD, Attock, GB, Reverter, JC, Lanir, N, Parapia, LA, Reynaud, J, Meili, E, von Felton, A, Martinowitz, U, Prangnell, DR, Krawczak, M and Cooper, DN (2000) Molecular analysis of the genotype-phenotype relationship in factor VII deficiency HUMAN GENETICS, 107 (4). pp. 327-342.

Shibata, M, Shima, M, Morichika, S, McVey, J, Tuddenham, EGD, Tanaka, I, Suzuki, H, Nogami, K, Minamoto, Y, Hato, T, Saenko, EL, Scandella, D and Yoshioka, A (2000) An alloantibody recognizing the FVIII A1 domain in a patient with CRM reduced haemophilia a due to deletion of a large portion of the A1 domain DNA sequence THROMBOSIS AND HAEMOSTASIS, 84 (3). pp. 442-448.

Dorling, A, Chen, D, Riesbeck, K, McVey, J, Kemball-Cook, G, Tuddenham, EG and Lechler, RI (2000) Regulated endothelial cell expression of novel anticoagulants: a strategy for the prevention and therapy of intravascular thrombosis. Transplant Proc, 32 (5).

Chen, DX, Riesbeck, K, McVey, JH, Kemball-Cook, G, Tuddenham, EGD, Lechler, RI and Dorling, A (1999) Regulated inhibition of coagulation by porcine endothelial cells expressing: P-selectin-tagged hirudin and tissue factor pathway inhibitor fusion proteins TRANSPLANTATION, 68 (6). pp. 832-839.

David, D, Santos, AIM, Johnson, K, Tuddenham, EGD and McVey, JH (1999) mRNA processing, translation and protein secretion from factor VIII genes containing premature stop codons: No correlation with inhibitor development THROMBOSIS AND HAEMOSTASIS. pp. 238-239.

Neerman-Arbez, M, Johnson, KM, Morris, MA, McVey, JH, Peyvandi, F, Nichols, WC, Ginsburg, D, Rossier, C, Antonarakis, SE and Tuddenham, EGD (1999) Molecular analysis of the ERGIC-53 gene in 35 families with combined factor V factor VIII deficiency BLOOD, 93 (7). pp. 2253-2260.

Chen, DX, Riesbeck, K, Kemball-Cook, G, McVey, JH, Tuddenham, EGD, Lechler, RI and Dorling, A (1999) Inhibition of tissue factor-dependent and -independent coagulation by cell surface expression of novel anticoagulant fusion proteins TRANSPLANTATION, 67 (3). pp. 467-474.

Riesbeck, K, Chen, DX, Kemball-Cook, G, McVey, JH, George, AJT, Tuddenham, EGD, Dorling, A and Lechler, RI (1998) Expression of hirudin fusion proteins in mammalian cells - A strategy for prevention of intravascular thrombosis CIRCULATION, 98 (24). pp. 2744-2752.

Mansvelt, EPG, Laffan, M, McVey, JH and Tuddenham, EGD (1998) Analysis of the F8 gene in individuals with high plasma factor VIII : C levels and associated venous thrombosis THROMBOSIS AND HAEMOSTASIS, 80 (4). pp. 561-565.

McVey, JH, Boswell, EJ, Takamiya, O, Tamagnini, G, Valente, V, Fidalgo, T, Layton, M and Tuddenham, EGD (1998) Exclusion of the first EGF domain of factor VII by a splice site mutation causes lethal factor VII deficiency BLOOD, 92 (3). pp. 920-926.

Tuddenham, EGD and McVey, JH (1998) The genetic basis of inhibitor development in haemophilia A HAEMOPHILIA, 4 (4). pp. 543-545.

Kemball-Cook, G, Johnson, DJD, Takamiya, O, Banner, DW, McVey, JH and Tuddenham, EGD (1998) Coagulation factor VII Gln(100)-> Arg - Amino acid substitution at the epidermal growth factor 2-protease domain interface results in severely reduced tissue factor binding and procoagulant function JOURNAL OF BIOLOGICAL CHEMISTRY, 273 (14). pp. 8516-8521.

Riesbeck, K, Dorling, A, KemballCook, G, McVey, JH, Jones, M, Tuddenham, EGD and Lechler, RI (1997) Human tissue factor pathway inhibitor fused to CD4 binds both FXa and TF/FVIIa at the cell surface THROMBOSIS AND HAEMOSTASIS, 78 (6). pp. 1488-1494.

Morichika, S, Shima, M, Kamisue, S, Tanaka, I, Imanaka, Y, Suzuki, H, Shibata, H, Pemberton, S, Gale, K, McVey, J, Tuddenham, EGD and Yoshioka, A (1997) Factor VIII gene analysis in Japanese CRM-positive and CRM-reduced haemophilia A patients by single-strand conformation polymorphism BRITISH JOURNAL OF HAEMATOLOGY, 98 (4). pp. 901-906.

Takamiya, O, Abe, S, Yoshioka, A, Nakajima, K, McVey, JH and Tuddenham, EG (1995) Factor VIIShinjo: a dysfunctional factor VII variant homozygous for the substitution Gln for Arg at position 79. Haemostasis, 25 (3). pp. 89-97.

Pugh, RE, McVey, JH, Tuddenham, EG and Hancock, JF (1995) Six point mutations that cause factor XI deficiency. Blood, 85 (6). pp. 1509-1516.

O'Brien, DP, Kemball-Cook, G, Hutchinson, AM, Martin, DM, Johnson, DJ, Byfield, PG, Takamiya, O, Tuddenham, EG and McVey, JH (1994) Surface plasmon resonance studies of the interaction between factor VII and tissue factor. Demonstration of defective tissue factor binding in a variant FVII molecule (FVII-R79Q). Biochemistry, 33 (47). pp. 14162-14169.

Nathwani, AC, Gale, KM, Pemberton, KD, Crossman, DC, Tuddenham, EG and McVey, JH (1994) Efficient gene transfer into human umbilical vein endothelial cells allows functional analysis of the human tissue factor gene promoter. Br J Haematol, 88 (1). pp. 122-128.

Kochhan, L, Lalloz, MR, Oldenburg, J, McVey, JH, Olek, K, Brackmann, HH, Tuddenham, EG and Schwaab, R (1994) Haemophilia A diagnosis by automated fluorescent DNA detection of ten factor VIII intron 13 dinucleotide repeat alleles. Blood Coagul Fibrinolysis, 5 (4). pp. 497-501.

Lalloz, MR, Schwaab, R, McVey, JH, Michaelides, K and Tuddenham, EG (1994) Haemophilia A diagnosis by simultaneous analysis of two variable dinucleotide tandem repeats within the factor VIII gene. Br J Haematol, 86 (4). pp. 804-809.

Kemball-Cook, G, Garner, I, Imanaka, Y, Nishimura, T, O'Brien, DP, Tuddenham, EG and McVey, JH (1994) High-level production of human blood coagulation factors VII and XI using a new mammalian expression vector. Gene, 139 (2). pp. 275-279.

McVey, JH, Michaelides, K, Hansen, LP, Ferguson-Smith, M, Tilghman, S, Krumlauf, R and Tuddenham, EG (1993) A G-->A substitution in an HNF I binding site in the human alpha-fetoprotein gene is associated with hereditary persistence of alpha-fetoprotein (HPAFP). Hum Mol Genet, 2 (4). pp. 379-384.

Lalloz, MR, McVey, JH, Pattinson, JK and Tuddenham, EG (1991) Haemophilia A diagnosis by analysis of a hypervariable dinucleotide repeat within the factor VIII gene. Lancet, 338 (8761). pp. 207-211.

Crossman, DC, Carr, DP, Tuddenham, EG, Pearson, JD and McVey, JH (1990) The regulation of tissue factor mRNA in human endothelial cells in response to endotoxin or phorbol ester. J Biol Chem, 265 (17). pp. 9782-9787.

Pattinson, JK, McVey, JH, Boon, M, Ajani, A and Tuddenham, EG (1990) CRM+ haemophilia A due to a missense mutation (372----Cys) at the internal heavy chain thrombin cleavage site. Br J Haematol, 75 (1). pp. 73-77.

Graham, A, Papalopulu, N, Lorimer, J, McVey, JH, Tuddenham, EG and Krumlauf, R (1988) Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene. Genes Dev, 2 (11). pp. 1424-1438.

Book Section

McVey, JH, Gomez, K and Tuddenham, EGD (2010) Normal Haemostasis In: Postgraduate Haematology. Wiley-Blackwell, pp. 746-771. ISBN 1405191805

Kemball-Cook, G, Tuddenham, EGD and McVey, JH (2007) Normal Haemostasis In: Postgraduate Haematology: Fifth Edition. UNSPECIFIED, pp. 783-807. ISBN 1405108215

Conference or Workshop Item

Bachli, E, Pech, CM, Johnson, KM, Tuddenham, EGD and McVey, JH (2000) Coagulation factors Xa and IIa but not VIIa induce a proinflammatory response in dermal fibroblasts.

Daxin, C, Riesbeck, K, McVey, J, Kembell-Cook, G, Tuddenham, EGD, Lechler, RI and Dorling, A (2000) Expression of novel anticoagulant fusion proteins inhibits factor Xa- and thrombin-induced activation of porcine vascular endothelial cells.

McVey, JH, Lal, K, Imanaka, Y, Nishimura, T, Kemball-Cook, G, Bolton-Maggs, PHB and Tuddenham, EGD (1999) Identification and characterization of the molecular defect in blood coagulation factor Xi T475I

Bold, RL, McVey, JH, Tuddenham, EGD and Kemball-Cook, G (1999) Recombinant expression and characterization of site-directed variants of the human factor VIIa active site catalytic triad

Chen, D, Riesbeck, K, McVey, JH, Kemball-Cook, G, Tuddenham, EGD, Lechler, RI and Dorling, A (1999) Regulated endothelial cell expression of novel molecules with anticoagulant properties: A strategy for the prevention and therapy of vascular rejection

David, D, Santos, AI, Jonson, D, Tuddenham, EGD, McVey, JH and Kemball-Cook, G (1999) Stable expression and characterization of CRM- (C329S) and a CRM+ (G1948D) factor VIII mutants using the B-domain deleted FVIIISQ variant

Michaelides, K, McVey, JH, Lal, K and Tuddenham, EGD (1999) The cloning and characterisation of the mouse platelet membrane glycoprotein IX gene

Bachli, EB, Nathwani, AC, Pech, C, Tuddenham, EGD and McVey, JH (1998) Characterisation of nuclear factors binding to the 5 ' untranslated region of the human tissue factor gene.

Bachli, EB, Tuddenham, EGD and McVey, JH (1998) Tissue factor expression in a transformed endothelial cell line.

Salooja, N, McVey, J and Tuddenham, EGD (1998) Towards gene therapy for haemophilia B: Two sensitive ELISAS for mouse FIX antigen.

David, D, Schwaab, R, Santos, AIM, McVey, J and Tuddenham, EGD (1998) Impact of premature stop codons on factor VIII and recombinant re-FVIIISQ pre-mRNA processing, correlation with inhibitor formation

Salooja, N, McVey, J, Carmeliet, P and Tuddenham, EGD (1997) Construction of a mouse model of factor IX deficiency.

Nathwani, AC, Pemberton, KD, Bachli, EB, Tuddenham, EGD and McVey, JH (1997) Expression of the human tissue factor gene in endothelial cells is downregulated by sequences in the 5' untranslated region.

Alshinawi, CR, Boswell, EJ, Felice, AE, Tuddenham, EGD and McVey, JH (1997) Characterization of two naturally occurring variants of human factor VII

Boswell, EJ, Tuddenham, EGD and McVey, JH (1997) Expression and characterisation of site-directed variants of the EGF-1 domain of human factor VII

Morichika, S, Shima, M, Tanaka, I, Nakai, B, Suzuki, H, Nogami, K, Hato, T, McVey, J, Tuddenham, EGD, Saenko, E, Scandella, D and Yoshioka, A (1996) A case of factor VIII C2 antigen positive hemophilia a with inhibitor recognizing the 44kDa Al domain: Identification of a large deletion from exon 4 TO 7.

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