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Items where Author is "Simmonds, R"

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Number of items: 34.

Article

Zong, Guanghui, Hu, Zhijian, O’Keefe, Sarah, Tranter, Dale, Iannotti, Michael J., Baron, Ludivine, Hall, Belinda, Corfield, Katherine, Paatero, Anja O., Henderson, Mark J., Roboti, Peristera, Zhou, Jianhong, Sun, Xianwei, Govindarajan, Mugunthan, Rohde, Jason M., Blanchard, Nicolas, Simmonds, Rachel, Inglese, James, Du, Yuchun, Demangel, Caroline, High, Stephen, Paavilainen, Ville O. and Shi, Wei Q. (2019) Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation Journal of the American Chemical Society, 141 (21). pp. 8450-8461.

Ogbechi, Joy, Hall, Belinda, Sbarrato, Thomas, Taunton, Jack, Willis, Anne E., Wek, Ronald C. and Simmonds, Rachel (2018) Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4 Cell Death & Disease, 9, 397.

McKenna, M, Simmonds, Rachel and High, S (2017) Mycolactone reveals substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis Journal of Cell Science, 130. pp. 1307-1320.

McKenna, M, Simmonds, RE and High, S (2016) Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone. Journal of Cell Science, 129.

Sarfo, FS, Phillips, R, Wansbrough-Jones, M and Simmonds, RE (2016) Recent advances: role of mycolactone in the pathogenesis and monitoring of Mycobacterium ulcerans infection/Buruli ulcer disease. Cell Microbiol, 18 (1). pp. 17-29.

Ogbechi, J, Ruf, MT, Hall, BS, Bodman-Smith, K, Vogel, M, Wu, HL, Stainer, A, Esmon, CT, Ahnström, J, Pluschke, G and Simmonds, RE (2015) Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions. PLoS Pathog, 11 (7).

Hall, BS, Hill, K, McKenna, M, Ogbechi, J, High, S, Willis, AE and Simmonds, RE (2014) The Pathogenic mechanism of the mycobacterium ulcerans virulence factor, mycolactone, deends on blockade of protein translocation intot he ER PLOS PATHOGENS, 10 (4).

Hall, B and Simmonds, R (2014) Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer. Biochem Soc Trans, 42 (1). pp. 177-183.

Barley, Elizabeth A., Haddad, Mark, Simmonds, Rosemary, Fortune, Zoe, Walters, Paul, Murray, Joanna, Rose, Diana and Tylee, Andre (2012) The UPBEAT depression and coronary heart disease programme: Using the UK medical research council framework to design a nurse-led complex intervention for use in primary care BMC FAMILY PRACTICE, 13, 119.

Brenner, C, Simmonds, RE, Wood, S, Rose, V, Feldmann, M and Turner, J (2012) TLR signalling and adapter utilization in primary human in vitro differentiated adipocytes. Scand J Immunol, 76 (4). pp. 359-370.

Simmonds, RE, Lali, FV, Smallie, T, Small, PLC and Foxwell, BM (2009) Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism JOURNAL OF IMMUNOLOGY, 182 (4). pp. 2194-2202.

Sacre, SM, Lo, A, Gregory, B, Simmonds, RE, Williams, L, Feldmann, M, Brennan, FM and Foxwell, BM (2008) Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures JOURNAL OF IMMUNOLOGY, 181 (11). pp. 8002-8009.

Simmonds, RE and Foxwell, BM (2008) Signalling, inflammation and arthritis - NF-kappa B and its relevance to arthritis and inflammation RHEUMATOLOGY, 47 (5). pp. 584-590.

White, SJ, Simmonds, RE, Lane, DA and Baker, AH (2005) Efficient isolation of peptide ligands for the endothelial cell protein C receptor (EPCR) using candidate receptor phage display biopanning PEPTIDES, 26 (7). pp. 1264-1269.

Biguzzi, E, Razzari, C, Lane, DA, Castaman, G, Cappellari, A, Bucciarelli, P, Fontana, G, Margaglione, M, D'Andrea, G, Simmonds, RE, Rezende, SM, Preston, R, Prisco, D and Faioni, EM (2005) Molecular diversity and thrombotic risk in Protein S deficiency: The PROSIT study HUMAN MUTATION, 25 (3). pp. 259-269.

Rezende, SM, Simmonds, RE and Lane, DA (2004) Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex BLOOD, 103 (4). pp. 1192-1201.

Rance, JB, Follows, GA, Cockerill, PN, Bonifer, C, Lane, DA and Simmonds, RE (2003) Regulation of the human endothelial cell protein C receptor gene promoter by multiple Sp1 binding sites BLOOD, 101 (11). pp. 4393-4401.

Mille-Baker, B, Rezende, SM, Simmonds, RE, Mason, PJ, Lane, DA and Laffan, MA (2003) Deletion or replacement of the second EGF-hke domain of protein S results in loss of APC cofactor activity BLOOD, 101 (4). pp. 1416-1418.

Rezende, SM, Lane, DA, Mille-Baker, B, Samama, MM, Conard, J and Simmonds, RE (2002) Protein S Gla-domain mutations causing impaired Ca2+-induced phospholipid binding and severe functional protein S deficiency BLOOD, 100 (8). pp. 2812-2819.

Rezende, SM, Lane, DA, Zoller, B, Mille-Baker, B, Laffan, M, Dahlback, B and Simmonds, RE (2002) Genetic and phenotypic variability between families with hereditary protein S deficiency THROMBOSIS AND HAEMOSTASIS, 87 (2). pp. 258-265.

Simmonds, RE and Lane, DA (2001) The endothelial cell protein C receptor: A candidate genetic risk factor for thrombosis THROMBOSIS AND HAEMOSTASIS, 86 (4). pp. 939-941.

Gandrille, S, Borgel, D, Sala, N, Espinosa-Parrilla, Y, Simmonds, R, Rezende, S, Lind, B, Mannhalter, C, Pabinger, I, Reitsma, PH, Formstone, C, Cooper, DN, Saito, H, Suzuki, K, Bernardi, F and Aiach, M (2000) Protein S deficiency: A database of mutations - Summary of the first update THROMBOSIS AND HAEMOSTASIS, 84 (5). p. 918.

Simmonds, RE, Philippou, H, Rance, J and Lane, DA (1999) Structural and functional implications of the intron/exon organisation of the human endothelial cell protein C/activated protein C receptor (EPCR) gene. Comparison with the structure of CD1/major histocompatibility complex alpha 1 and alpha 2 domains THROMBOSIS AND HAEMOSTASIS. p. 14.

Rezende, SM, Simmonds, RE, Zoller, B, Dahlback, B and Lane, DA (1999) The molecular basis of type I/III protein S deficiency THROMBOSIS AND HAEMOSTASIS. pp. 426-427.

Simmonds, RE and Lane, DA (1999) Structural and functional implications of the intron exon organization of the human endothelial cell protein C activated protein C receptor (EPCR) gene: Comparison with the structure of CD1/major histocompatibility complex alpha 1 and alpha 2 domains BLOOD, 94 (2). pp. 632-641.

Simmonds, RE, Ireland, H, Lane, DA, Zoller, B, de Frutos, PG and Dahlback, B (1998) Clarification of the risk for venous thrombosis associated with hereditary protein S deficiency by investigation of a large kindred with a characterized gene defect ANNALS OF INTERNAL MEDICINE, 128 (1). 8-+.

Wood, SA, Long, JM, Simmonds, RJ, Bridges, JW and Stevenson, D (1997) Optimisation of the enantiomeric separation of 12 2-aminotetralin analogues using Chiral AGP high-performance liquid chromatography by simultaneous factorial design JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 16 (2). pp. 231-237.

Gandrille, S, Borgel, D, Ireland, H, Lane, DA, Simmonds, R, Reitsma, PH, Mannhalter, C, Pabinger, I, Saito, H, Suzuki, K, Formstone, C, Cooper, DN, Espinosa, Y, Sala, N, Bernardi, F and Alach, M (1997) Protein S deficiency: A database of mutations - For the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis THROMBOSIS AND HAEMOSTASIS, 77 (6). pp. 1201-1214.

Simmonds, RE, Ireland, H, Kunz, G, Lane, DA, Bhavnani, M, Castaman, G, Hambley, H, Laffan, M, OConnor, N, Sas, G, Tew, CJ and Walker, ID (1996) Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis BLOOD, 88 (11). pp. 4195-4204.

Wood, SA, Pegg, SN, Simmonds, RJ and Stevenson, D (1996) Development of chiral high performance liquid chromatographic assays for the enantiomers of 8-hydroxy-(di-n-propylamino)tetralin and three 8-keto-pyrrole-substituted analogues JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 14 (11). pp. 1591-1599.

Wood, SA, Parton, AH, Simmonds, RJ and Stevenson, D (1996) Stereoselective metabolism of two keto-pyrrol analogues of 8-hydroxy-2-dipropyl-aminotetralin by freshly isolated rat hepatocytes CHIRALITY, 8 (3). pp. 264-270.

Book Section

Hall, BS, Simmonds, R, Benbow, ME, Mosi, L, Roberts, S and Williamso Jordan, H (2015) Mycobacterium ulcerans and Buruli Ulcer In: Human Emerging and Re-emerging Infections: Viral and Parasitic Infections, Volume I. John Wiley and Sons, Hoboken, NJ, USA.

Conference or Workshop Item

Moyo, N, Westcott, D, Simmonds, R and Steinbach, F (2012) Equine arteritis virus replication in monocytic cells suppresses differentiation and function of dendritic cells In: European Congress of Immunology, 2012-09-05 - 2012-09-08, Glasgow, SCOTLAND.

Simmonds, RE, Hermida, J, Rezende, SM and Lane, DA (2001) Haemostatic genetic risk factors in arterial thrombosis In: XVIIIth Congress of the International-Society-on-Thrombosis-and-Haemostasis, 2001-07-06 - 2001-07-12, PARIS, FRANCE.

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