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Items where Author is "LEWIS, D"

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AYALOGU, EO, SNELLING, J, LEWIS, DFV, TALWAR, S, CLIFFORD, MN and IOANNIDES, C (1995) INDUCTION OF HEPATIC CYP1A2 BY THE ORAL-ADMINISTRATION OF CAFFEINE TO RATS - LACK OF ASSOCIATION WITH THE AH LOCUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1272 (2). pp. 89-94.

LEWIS, DJM and GRIFFIN, GE (1995) IMMUNOLOGY OF THE GASTROINTESTINAL-TRACT CURRENT OPINION IN INFECTIOUS DISEASES, 8 (5). pp. 368-373.

BOYD, GW, COOMBS, MM, IOANNIDES, C, LEWIS, DFV, SNELLING, J and TSAKALOF, A (1995) SPECIES VARIATION IN THE METABOLISM OF 15,16-DIHYDRO-11-METHYLCYCLOPENTA[A]PHENANTHREN-17-ONE TO ITS 3,4-DIHYDRODIOL, THE PROXIMATE CARCINOGEN CARCINOGENESIS, 16 (10). pp. 2351-2355.

LEWIS, DFV, IOANNIDES, C, WALKER, R and PARKE, DV (1995) QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS AND COMPACT ANALYSIS OF A SERIES OF FOOD MUTAGENS FOOD ADDITIVES AND CONTAMINANTS, 12 (5). pp. 715-723.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1995) A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDY ON A SERIES OF 10 PARASUBSTITUTED TOLUENES BINDING TO CYTOCHROME P4502B4 (CYP2B4), AND THEIR HYDROXYLATION RATES BIOCHEMICAL PHARMACOLOGY, 50 (5). pp. 619-625.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1995) COMPACT PREDICTIONS - IS THERE A CATCH - RESPONSE ENVIRONMENTAL HEALTH PERSPECTIVES, 103 (6). pp. 537-538.

CASTELLOBRANCO, LRR, GRIFFIN, GE, DOUGAN, G and LEWIS, DJM (1995) A METHOD TO SCREEN T-LYMPHOCYTE EPITOPES AFTER ORAL IMMUNIZATION OF HUMANS - APPLICATION TO CHOLERA-TOXIN B-SUBUNIT VACCINE, 13 (9). pp. 817-820.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1995) COMPUTER-GRAPHICS ANALYSIS OF THE INTERACTION OF ALKOXY METHYLENEDIOXYBENZENES WITH CYTOCHROMES P4501 TOXICOLOGY LETTERS, 76 (1). pp. 39-45.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1995) A RETROSPECTIVE EVALUATION OF COMPACT PREDICTIONS OF THE OUTCOME OF NTP RODENT CARCINOGENICITY TESTING ENVIRONMENTAL HEALTH PERSPECTIVES, 103 (2). pp. 178-184.

LEWIS, DFV, IOANNIDES, C, WALKER, R and PARKE, DV (1994) SAFETY EVALUATIONS OF FOOD CHEMICALS BY COMPACT .1. A STUDY OF SOME ACYCLIC TERPENES FOOD AND CHEMICAL TOXICOLOGY, 32 (11). pp. 1053-1059.

LEWIS, DFV, LAKE, BG, IOANNIDES, C and PARKE, DV (1994) INHIBITION OF RAT HEPATIC ARYL-HYDROCARBON HYDROXYLASE-ACTIVITY BY A SERIES OF 7-HYDROXY COUMARINS - QSAR STUDIES XENOBIOTICA, 24 (9). pp. 829-838.

IOANNIDES, C, LEWIS, DFV and PARKE, DV (1994) THE USE OF COMPUTERS IN THE SAFETY EVALUATION OF DRUGS AND OTHER CHEMICALS EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 19 (3). pp. 225-233.

LEWIS, DJM, GILKS, CF, OJOO, S, CASTELLOBRANCO, LRR, DOUGAN, G, EVANS, MRW, MCDERMOTT, S and GRIFFIN, GE (1994) IMMUNE-RESPONSE FOLLOWING ORAL-ADMINISTRATION OF CHOLERA-TOXIN-B SUBUNIT TO HIV-1-INFECTED UK AND KENYAN SUBJECTS AIDS, 8 (6). pp. 779-785.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1994) INTERACTION OF A SERIES OF NITRILES WITH THE ALCOHOL-INDUCIBLE ISOFORM OF P450 - COMPUTER-ANALYSIS OF STRUCTURE-ACTIVITY-RELATIONSHIPS XENOBIOTICA, 24 (5). pp. 401-408.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1994) MOLECULAR MODELING OF CYTOCHROME CYP1A1 - A PUTATIVE ACCESS CHANNEL EXPLAINS DIFFERENCES IN INDUCTION POTENCY BETWEEN THE ISOMERS BENZO(A)PYRENE AND BENZO(E)PYRENE, AND 2-ACETYLAMINOFLUORENE AND 4-ACETYLAMINOFLUORENE TOXICOLOGY LETTERS, 71 (3). pp. 235-243.

REKKA, E, AYALOGU, EO, LEWIS, DFV, GIBSON, GG and IOANNIDES, C (1994) INDUCTION OF HEPATIC-MICROSOMAL CYP4A ACTIVITY AND OF PEROXISOMAL BETA-OXIDATION BY 2 NONSTEROIDAL ANTIINFLAMMATORY DRUGS ARCHIVES OF TOXICOLOGY, 68 (2). pp. 73-78.

CASTELLOBRANCO, LRR, GRIFFIN, GE, POULTON, TA, DOUGAN, G and LEWIS, DJM (1994) CHARACTERIZATION OF THE CIRCULATING T-CELL RESPONSE AFTER ORAL IMMUNIZATION OF HUMAN VOLUNTEERS WITH CHOLERA-TOXIN-B SUBUNIT VACCINE, 12 (1). pp. 65-72.

LEWIS, DFV, MOEREELS, H, LAKE, BG, IOANNIDES, C and PARKE, DV (1994) MOLECULAR MODELING OF ENZYMES AND RECEPTORS INVOLVED IN CARCINOGENESIS - QSARS AND COMPACT-3D DRUG METABOLISM REVIEWS, 26 (1-2). pp. 261-285.

LEWIS, DJM (1993) SEROLOGICAL CORRELATES OF SUSCEPTIBILITY TO PERTUSSIS VACCINE, 11 (12). p. 1269.

IOANNIDES, C, CHEUNG, YL, WILSON, J, LEWIS, DFV and GRAY, TJB (1993) THE MUTAGENICITY AND INTERACTIONS OF 2-(ACETYLAMINO)FLUORENE AND 4-(ACETYLAMINO)FLUORENE WITH CYTOCHROME-P450 AND THE AROMATIC HYDROCARBON RECEPTOR MAY EXPLAIN THE DIFFERENCE IN THEIR CARCINOGENIC POTENCY CHEMICAL RESEARCH IN TOXICOLOGY, 6 (4). pp. 535-541.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1993) VALIDATION OF A NOVEL MOLECULAR-ORBITAL APPROACH (COMPACT) FOR THE PROSPECTIVE SAFETY EVALUATION OF CHEMICALS, BY COMPARISON WITH RODENT CARCINOGENICITY AND SALMONELLA MUTAGENICITY DATA EVALUATED BY THE UNITED-STATES NCI NTP MUTATION RESEARCH, 291 (1). pp. 61-77.

LEWIS, DJM, CASTELLOBRANCO, LRR, NOVOTNY, P, DOUGAN, G, POULTON, TA and GRIFFIN, GE (1993) CIRCULATING CELLULAR IMMUNE-RESPONSE TO ORAL IMMUNIZATION OF HUMANS WITH CHOLERA-TOXIN B-SUBUNIT VACCINE, 11 (2). pp. 119-121.

IOANNIDES, C, AYRTON, AD, LEWIS, DFV and WALKER, R (1993) EXTRAPOLATION OF IN-VITRO ANTIMUTAGENICITY TO THE IN-VIVO SITUATION - THE CASE FOR ANTHRAFLAVIC ACID ANTIMUTAGENESIS AND ANTICARCINOGENESIS MECHANISMS III, 61. pp. 103-110.

LEWIS, DG, SWINDELL, W, MORTON, EJ, EVANS, PM and XIAO, ZR (1992) A MEGAVOLTAGE CT SCANNER FOR RADIOTHERAPY VERIFICATION PHYSICS IN MEDICINE AND BIOLOGY, 37 (10). pp. 1985-1999.

AYRTON, AD, LEWIS, DFV, WALKER, R and IOANNIDES, C (1992) ANTIMUTAGENICITY OF ELLAGIC ACID TOWARDS THE FOOD MUTAGEN IQ - INVESTIGATION INTO POSSIBLE MECHANISMS OF ACTION FOOD AND CHEMICAL TOXICOLOGY, 30 (4). pp. 289-295.

LEWIS, DJM and FREEDMAN, AR (1992) GIARDIA-LAMBLIA AS AN INTESTINAL PATHOGEN DIGESTIVE DISEASES, 10 (2). pp. 102-111.

SWINDELL, W, MORTON, EJ, EVANS, PM and LEWIS, DG (1991) THE DESIGN OF MEGAVOLTAGE PROJECTION IMAGING-SYSTEMS - SOME THEORETICAL ASPECTS MEDICAL PHYSICS, 18 (5). pp. 855-866.

LEWIS, DJM, NOVOTNY, P, DOUGAN, G and GRIFFIN, GE (1991) THE EARLY CELLULAR AND HUMORAL IMMUNE-RESPONSE TO PRIMARY AND BOOSTER ORAL IMMUNIZATION WITH CHOLERA TOXIN-B SUBUNIT EUROPEAN JOURNAL OF IMMUNOLOGY, 21 (9). pp. 2087-2094.

MORTON, EJ, SWINDELL, W, LEWIS, DG and EVANS, PM (1991) A LINEAR-ARRAY, SCINTILLATION CRYSTAL PHOTODIODE DETECTOR FOR MEGAVOLTAGE IMAGING MEDICAL PHYSICS, 18 (4). pp. 681-691.

PARKE, DV, IOANNIDES, C and LEWIS, DFV (1991) THE 1990 PHARMACEUTICAL-MANUFACTURERS-ASSOCIATION-OF-CANADA KEYNOTE LECTURE - THE ROLE OF THE CYTOCHROMES-P450 IN THE DETOXICATION AND ACTIVATION OF DRUGS AND OTHER CHEMICALS CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 69 (5). pp. 537-549.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1990) A RETROSPECTIVE STUDY OF THE MOLECULAR TOXICOLOGY OF BENOXAPROFEN TOXICOLOGY, 65 (1-2). pp. 33-47.

PARKE, DV, IOANNIDES, C and LEWIS, DFV (1990) THE SAFETY EVALUATION OF DRUGS AND CHEMICALS BY THE USE OF COMPUTER OPTIMIZED MOLECULAR PARAMETRIC ANALYSIS OF CHEMICAL TOXICITY (COMPACT) ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 18. pp. 91-102.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1990) A PROSPECTIVE TOXICITY EVALUATION (COMPACT) ON 40 CHEMICALS CURRENTLY BEING TESTED BY THE NATIONAL-TOXICOLOGY-PROGRAM MUTAGENESIS, 5 (5). pp. 433-435.

IOANNIDES, C, AYRTON, AD, KEELE, A, LEWIS, DFV, FLATT, PR and WALKER, R (1990) MECHANISM OF THE INVITRO ANTIMUTAGENIC ACTION OF RETINOL MUTAGENESIS, 5 (3). pp. 257-262.

SMITH, JN, AYRTON, AD, CHOWN, J, LEWIS, DFV and IOANNIDES, C (1990) FEPRAZONE - AN INDUCER OF THE P450-II-B FAMILY OF PROTEINS IN THE RAT JOURNAL OF BIOCHEMICAL TOXICOLOGY, 5 (1). pp. 9-12.

PARKE, DV, IOANNIDES, C and LEWIS, DFV (1990) COMPUTER MODELING AND INVITRO TESTS IN THE SAFETY EVALUATION OF CHEMICALS - STRATEGIC APPLICATIONS TOXICOLOGY IN VITRO, 4 (4-5). pp. 680-685.

LEWIS, DFV, RODRIGUES, AD, IOANNIDES, C and PARKE, DV (1989) ADVERSE REACTIONS OF IMIDAZOLE ANTIFUNGAL AGENTS - COMPUTER GRAPHIC STUDIES OF CYTOCHROME-P-450 INTERACTIONS JOURNAL OF BIOCHEMICAL TOXICOLOGY, 4 (4). pp. 231-234.

IOANNIDES, C, LEWIS, DFV, TRINICK, J, NEVILLE, S, SERTKAYA, NN, KAJBAF, M and GORROD, JW (1989) A RATIONALE FOR THE NON-MUTAGENICITY OF 2-AMINOBIPHENYLS AND 3-AMINOBIPHENYLS CARCINOGENESIS, 10 (8). pp. 1403-1407.

RODRIGUES, AD, AYRTON, AD, WILLIAMS, EJ, LEWIS, DFV, WALKER, R and IOANNIDES, C (1989) PREFERENTIAL INDUCTION OF THE RAT HEPATIC P-450 I-PROTEINS BY THE FOOD CARCINOGEN 2-AMINO-3-METHYL-IMIDAZO[4,5-F]QUINOLINE EUROPEAN JOURNAL OF BIOCHEMISTRY, 181 (3). pp. 627-631.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1989) MOLECULAR-ORBITAL STUDIES OF OXYGEN ACTIVATION AND MECHANISMS OF CYTOCHROMES-P-450-MEDIATED OXIDATIVE-METABOLISM OF XENOBIOTICS CHEMICO-BIOLOGICAL INTERACTIONS, 70 (3-4). pp. 263-280.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1989) PREDICTION OF CHEMICAL CARCINOGENICITY FROM MOLECULAR AND ELECTRONIC-STRUCTURES - A COMPARISON OF MINDO/3 AND CNDO/2 MOLECULAR-ORBITAL METHODS TOXICOLOGY LETTERS, 45 (1). pp. 1-13.

PARKE, DV, IOANNIDES, C and LEWIS, DFV (1988) METABOLIC-ACTIVATION OF CARCINOGENS AND TOXIC-CHEMICALS HUMAN TOXICOLOGY, 7 (5). pp. 397-404.

AYRTON, AD, LEWIS, DFV, IOANNIDES, C and WALKER, R (1987) ANTHRAFLAVIC ACID IS A POTENT AND SPECIFIC INHIBITOR OF CYTOCHROME-P-448 ACTIVITY BIOCHIMICA ET BIOPHYSICA ACTA, 916 (3). pp. 328-331.

RODRIGUES, AD, LEWIS, DFV, IOANNIDES, C and PARKE, DV (1987) SPECTRAL AND KINETIC-STUDIES OF THE INTERACTION OF IMIDAZOLE ANTIFUNGAL AGENTS WITH MICROSOMAL CYTOCHROMES-P-450 XENOBIOTICA, 17 (11). pp. 1315-1327.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1987) STRUCTURAL REQUIREMENTS FOR SUBSTRATES OF CYTOCHROME-P-450 AND CYTOCHROME-P-448 CHEMICO-BIOLOGICAL INTERACTIONS, 64 (1-2). pp. 39-60.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1986) MOLECULAR DIMENSIONS OF THE SUBSTRATE BINDING-SITE OF CYTOCHROME-P-448 BIOCHEMICAL PHARMACOLOGY, 35 (13). pp. 2179-2185.

Conference or Workshop Item

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1993) PREDICTION OF THE CARCINOGENIC POTENTIAL BY COMPUTER-OPTIMIZED MOLECULAR PARAMETRIC ANALYSIS OF CHEMICAL TOXICITY (COMPACT) VIA CYTOCHROME-P450 INTERACTIONS In: 13TH INTERNATIONAL SYMP ON POLYNUCLEAR AROMATIC HYDROCARBONS ( PAH 13 ), 1991-10-01 - 1991-10-04, BORDEAUX, FRANCE.

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