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IRIZAR, A, BARNETT, CR, FLATT, PR and IOANNIDES, C (1995) DEFECTIVE EXPRESSION OF CYTOCHROME-P450 PROTEINS IN THE LIVER OF THE GENETICALLY-OBESE ZUCKER RAT EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION, 293 (4). pp. 385-393.

AYALOGU, EO, SNELLING, J, LEWIS, DFV, TALWAR, S, CLIFFORD, MN and IOANNIDES, C (1995) INDUCTION OF HEPATIC CYP1A2 BY THE ORAL-ADMINISTRATION OF CAFFEINE TO RATS - LACK OF ASSOCIATION WITH THE AH LOCUS BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1272 (2). pp. 89-94.

BOYD, GW, COOMBS, MM, IOANNIDES, C, LEWIS, DFV, SNELLING, J and TSAKALOF, A (1995) SPECIES VARIATION IN THE METABOLISM OF 15,16-DIHYDRO-11-METHYLCYCLOPENTA[A]PHENANTHREN-17-ONE TO ITS 3,4-DIHYDRODIOL, THE PROXIMATE CARCINOGEN CARCINOGENESIS, 16 (10). pp. 2351-2355.

IRIZAR, A and IOANNIDES, C (1995) EXTRAHEPATIC EXPRESSION OF P450 PROTEINS IN INSULIN-DEPENDENT DIABETES-MELLITUS XENOBIOTICA, 25 (9). pp. 941-949.

LEWIS, DFV, IOANNIDES, C, WALKER, R and PARKE, DV (1995) QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS AND COMPACT ANALYSIS OF A SERIES OF FOOD MUTAGENS FOOD ADDITIVES AND CONTAMINANTS, 12 (5). pp. 715-723.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1995) A QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDY ON A SERIES OF 10 PARASUBSTITUTED TOLUENES BINDING TO CYTOCHROME P4502B4 (CYP2B4), AND THEIR HYDROXYLATION RATES BIOCHEMICAL PHARMACOLOGY, 50 (5). pp. 619-625.

IRIZAR, A and IOANNIDES, C (1995) EXPRESSION AND INDUCIBILITY OF CYTOCHROME-P450 PROTEINS BELONGING TO FAMILY-2,3 AND FAMILY-4 IN THE RABBIT AORTA BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 213 (3). pp. 916-921.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1995) COMPACT PREDICTIONS - IS THERE A CATCH - RESPONSE ENVIRONMENTAL HEALTH PERSPECTIVES, 103 (6). pp. 537-538.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1995) COMPUTER-GRAPHICS ANALYSIS OF THE INTERACTION OF ALKOXY METHYLENEDIOXYBENZENES WITH CYTOCHROMES P4501 TOXICOLOGY LETTERS, 76 (1). pp. 39-45.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1995) A RETROSPECTIVE EVALUATION OF COMPACT PREDICTIONS OF THE OUTCOME OF NTP RODENT CARCINOGENICITY TESTING ENVIRONMENTAL HEALTH PERSPECTIVES, 103 (2). pp. 178-184.

BOYD, GW, COOMBS, MM and IOANNIDES, C (1995) CYP1 INDUCTION, BINDING TO THE HEPATIC AROMATIC HYDROCARBON RECEPTOR AND MUTAGENICITY OF A SERIES OF 11-ALKOXY CYCLOPENTA[A]PHENANTHREN-17-ONES - A STRUCTURE-ACTIVITY RELATIONSHIP TOXICOLOGY, 95 (1-3). pp. 27-35.

BOYD, GW, IOANNIDES, C and COOMBS, MM (1995) THE INFLUENCE OF DIHYDRODIOL CONFORMATION ON THE METABOLIC-ACTIVATION OF CYCLOPENTA[A]PHENANTHRENES TOXICOLOGY LETTERS, 75 (1-3). pp. 93-100.

SHAVILA, J, IOANNIDES, C, KING, LJ and PARKE, DV (1994) EFFECT OF HIGH-FAT DIET ON LIVER MICROSOMAL OXYGENATIONS IN FERRET XENOBIOTICA, 24 (11). pp. 1063-1076.

LEWIS, DFV, IOANNIDES, C, WALKER, R and PARKE, DV (1994) SAFETY EVALUATIONS OF FOOD CHEMICALS BY COMPACT .1. A STUDY OF SOME ACYCLIC TERPENES FOOD AND CHEMICAL TOXICOLOGY, 32 (11). pp. 1053-1059.

BUABBAS, A, CLIFFORD, MN, WALKER, R and IOANNIDES, C (1994) SELECTIVE INDUCTION OF RAT HEPATIC CYP1 AND CYP4 PROTEINS AND OF PEROXISOMAL PROLIFERATION BY GREEN TEA CARCINOGENESIS, 15 (11). pp. 2575-2579.

LEWIS, DFV, LAKE, BG, IOANNIDES, C and PARKE, DV (1994) INHIBITION OF RAT HEPATIC ARYL-HYDROCARBON HYDROXYLASE-ACTIVITY BY A SERIES OF 7-HYDROXY COUMARINS - QSAR STUDIES XENOBIOTICA, 24 (9). pp. 829-838.

BUABBAS, A, IOANNIDES, C and WALKER, R (1994) EVALUATION OF THE ANTIMUTAGENIC POTENTIAL OF ANTHRACENE - IN-VITRO AND EX-VIVO STUDIES MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 309 (1). pp. 101-107.

BUABBAS, A, CLIFFORD, MN, WALKER, R and IOANNIDES, C (1994) MARKED ANTIMUTAGENIC POTENTIAL OF AQUEOUS GREEN TEA EXTRACTS - MECHANISM OF ACTION MUTAGENESIS, 9 (4). pp. 325-331.

IOANNIDES, C, LEWIS, DFV and PARKE, DV (1994) THE USE OF COMPUTERS IN THE SAFETY EVALUATION OF DRUGS AND OTHER CHEMICALS EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 19 (3). pp. 225-233.

CHEUNG, YL, PUDDICOMBE, SM, GRAY, TJB and IOANNIDES, C (1994) MUTAGENICITY AND CYP1A INDUCTION BY AZOBENZENES CORRELATES WITH THEIR CARCINOGENICITY CARCINOGENESIS, 15 (6). pp. 1257-1263.

MARCZYLO, T and IOANNIDES, C (1994) BIOACTIVATION OF 6-AMINOCHRYSENE BY ANIMAL AND HUMAN HEPATIC PREPARATIONS - CONTRIBUTIONS OF MICROSOMAL AND CYTOSOLIC ENZYME-SYSTEMS MUTAGENESIS, 9 (3). pp. 233-239.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1994) INTERACTION OF A SERIES OF NITRILES WITH THE ALCOHOL-INDUCIBLE ISOFORM OF P450 - COMPUTER-ANALYSIS OF STRUCTURE-ACTIVITY-RELATIONSHIPS XENOBIOTICA, 24 (5). pp. 401-408.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1994) MOLECULAR MODELING OF CYTOCHROME CYP1A1 - A PUTATIVE ACCESS CHANNEL EXPLAINS DIFFERENCES IN INDUCTION POTENCY BETWEEN THE ISOMERS BENZO(A)PYRENE AND BENZO(E)PYRENE, AND 2-ACETYLAMINOFLUORENE AND 4-ACETYLAMINOFLUORENE TOXICOLOGY LETTERS, 71 (3). pp. 235-243.

BARNETT, CR, FLATT, PR and IOANNIDES, C (1994) MODULATION OF THE RAT HEPATIC CYTOCHROME-P450 COMPOSITION BY LONG-TERM STREPTOZOTOCIN-INDUCED INSULIN-DEPENDENT DIABETES JOURNAL OF BIOCHEMICAL TOXICOLOGY, 9 (2). pp. 63-69.

REKKA, E, AYALOGU, EO, LEWIS, DFV, GIBSON, GG and IOANNIDES, C (1994) INDUCTION OF HEPATIC-MICROSOMAL CYP4A ACTIVITY AND OF PEROXISOMAL BETA-OXIDATION BY 2 NONSTEROIDAL ANTIINFLAMMATORY DRUGS ARCHIVES OF TOXICOLOGY, 68 (2). pp. 73-78.

PARKE, DV and IOANNIDES, C (1994) THE EFFECTS OF NUTRITION ON CHEMICAL TOXICITY DRUG METABOLISM REVIEWS, 26 (4). pp. 739-765.

LEWIS, DFV, MOEREELS, H, LAKE, BG, IOANNIDES, C and PARKE, DV (1994) MOLECULAR MODELING OF ENZYMES AND RECEPTORS INVOLVED IN CARCINOGENESIS - QSARS AND COMPACT-3D DRUG METABOLISM REVIEWS, 26 (1-2). pp. 261-285.

GORROD, JW, IOANNIDES, C, LAM, SP and NEVILLE, S (1993) MUTAGENICITY TESTING OF 9-N-SUBSTITUTED ADENINES AND THEIR N-OXIDATION PRODUCTS ENVIRONMENTAL HEALTH PERSPECTIVES, 101. pp. 21-26.

BOYD, GW, YOUNG, RJ, HARVEY, RG, COOMBS, MM and IOANNIDES, C (1993) CYTOCHROME-P450-DEPENDENT METABOLISM AND MUTAGENICITY OF 15,16-DIHYDRO-11-METHYLCYCLOPENTA[A]PHENANTHREN-17-ONE AND THEIR IMPLICATIONS IN ITS CARCINOGENICITY CARCINOGENESIS, 14 (9). pp. 1783-1788.

PAPAPARASKEVAPETRIDES, C, IOANNIDES, C and WALKER, R (1993) CONTRIBUTION OF PHENOLIC AND QUINONOID STRUCTURES IN THE MUTAGENICITY OF THE EDIBLE MUSHROOM AGARICUS-BISPORUS FOOD AND CHEMICAL TOXICOLOGY, 31 (8). pp. 561-567.

BOYD, GW, ZEPIK, HH, KING, LM, IOANNIDES, C and COOMBS, MM (1993) THE IN-VITRO METABOLIC-ACTIVATION OF THE 11-TRIFLUOROMETHYL ANALOG OF THE POTENT CARCINOGEN 15,16-DIHYDRO-11-METHYL-CYCLOPENTA[A]-PHENANTHREN-17-ONE TO MUTAGENS CARCINOGENESIS, 14 (8). pp. 1697-1699.

LIU, PT, IOANNIDES, C, SYMONS, AM and PARKE, DV (1993) ROLE OF TISSUE GLUTATHIONE IN PREVENTION OF SURGICAL TRAUMA XENOBIOTICA, 23 (8). pp. 899-911.

IOANNIDES, C and PARKE, DV (1993) SPECIAL ISSUE - TOXICOLOGICAL ASPECTS OF GLUTATHIONE - EDITORIAL XENOBIOTICA, 23 (8). pp. 821-822.

CHEUNG, YL, GRAY, TJB and IOANNIDES, C (1993) MUTAGENICITY OF CHRYSENE, ITS METHYL AND BENZO DERIVATIVES, AND THEIR INTERACTIONS WITH CYTOCHROMES-P-450 AND THE AH-RECEPTOR - RELEVANCE TO THEIR CARCINOGENIC POTENCY TOXICOLOGY, 81 (1). pp. 69-86.

IOANNIDES, C, CHEUNG, YL, WILSON, J, LEWIS, DFV and GRAY, TJB (1993) THE MUTAGENICITY AND INTERACTIONS OF 2-(ACETYLAMINO)FLUORENE AND 4-(ACETYLAMINO)FLUORENE WITH CYTOCHROME-P450 AND THE AROMATIC HYDROCARBON RECEPTOR MAY EXPLAIN THE DIFFERENCE IN THEIR CARCINOGENIC POTENCY CHEMICAL RESEARCH IN TOXICOLOGY, 6 (4). pp. 535-541.

PAPAPARASKEVAPETRIDES, C, IOANNIDES, C, BOYD, GW, YOUNG, RJ, HARVEY, RG and COOMBS, MM (1993) THE MUTAGENICITY OF CHEMICALLY SYNTHESIZED METABOLITES OF 16,17-DIHYDRO-15H-CYCLOPENTA[A]PHENANTHRENE AND ITS CARCINOGENIC 11-METHYL HOMOLOG MUTAGENESIS, 8 (4). pp. 307-310.

BOYD, GW, YOUNG, RJ, HARVEY, RG, COOMBS, MM and IOANNIDES, C (1993) THE METABOLISM AND ACTIVATION OF 15,16-DIHYDROCYCLOPENTA[A]PHENANTHREN-17-ONE BY CYTOCHROME-P-450 PROTEINS EUROPEAN JOURNAL OF PHARMACOLOGY-ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY SECTION, 228 (5-6). pp. 275-282.

LIU, PT, IOANNIDES, C, SHAVILA, J, SYMONS, AM and PARKE, DV (1993) EFFECTS OF ETHER ANESTHESIA AND FASTING ON VARIOUS CYTOCHROMES-P450 OF RAT-LIVER AND KIDNEY BIOCHEMICAL PHARMACOLOGY, 45 (4). pp. 871-877.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1993) VALIDATION OF A NOVEL MOLECULAR-ORBITAL APPROACH (COMPACT) FOR THE PROSPECTIVE SAFETY EVALUATION OF CHEMICALS, BY COMPARISON WITH RODENT CARCINOGENICITY AND SALMONELLA MUTAGENICITY DATA EVALUATED BY THE UNITED-STATES NCI NTP MUTATION RESEARCH, 291 (1). pp. 61-77.

BARNETT, CR, RUDD, S, FLATT, PR and IOANNIDES, C (1993) SEX-DIFFERENCES IN THE DIABETES-INDUCED MODULATION OF RAT HEPATIC CYTOCHROME-P450 PROTEINS BIOCHEMICAL PHARMACOLOGY, 45 (2). pp. 313-319.

IOANNIDES, C, AYRTON, AD, LEWIS, DFV and WALKER, R (1993) EXTRAPOLATION OF IN-VITRO ANTIMUTAGENICITY TO THE IN-VIVO SITUATION - THE CASE FOR ANTHRAFLAVIC ACID ANTIMUTAGENESIS AND ANTICARCINOGENESIS MECHANISMS III, 61. pp. 103-110.

IOANNIDES, C and PARKE, DV (1993) INDUCTION OF CYTOCHROME P4501 AS AN INDICATOR OF POTENTIAL CHEMICAL CARCINOGENESIS DRUG METABOLISM REVIEWS, 25 (4). pp. 485-501.

BARNETT, CR, PETRIDES, L, WILSON, J, FLATT, PR and IOANNIDES, C (1992) INDUCTION OF RAT HEPATIC MIXED-FUNCTION OXIDASES BY ACETONE AND OTHER PHYSIOLOGICAL KETONES - THEIR ROLE IN DIABETES-INDUCED CHANGES IN CYTOCHROME P450 PROTEINS XENOBIOTICA, 22 (12). pp. 1441-1450.

SHAVILA, J, IOANNIDES, C, KING, LJ and PARKE, DV (1992) HEPATIC MIXED-FUNCTION OXIDASES OF FERRET XENOBIOTICA, 22 (8). pp. 1003-1014.

BARNETT, CR, FLATT, PR and IOANNIDES, C (1992) THE MODULATION OF HEPATIC MIXED-FUNCTION OXIDASE ACTIVITY BY INSULINOMA REGULATORY PEPTIDES, 39 (2-3). p. 273.

BARNETT, CR, ABBOTT, RA, BAILEY, CJ, FLATT, PR and IOANNIDES, C (1992) CYTOCHROME-P450-DEPENDENT MIXED-FUNCTION OXIDASE AND GLUTATHIONE-S-TRANSFERASE ACTIVITIES IN SPONTANEOUS OBESITY-DIABETES BIOCHEMICAL PHARMACOLOGY, 43 (8). pp. 1868-1871.

AYRTON, AD, LEWIS, DFV, WALKER, R and IOANNIDES, C (1992) ANTIMUTAGENICITY OF ELLAGIC ACID TOWARDS THE FOOD MUTAGEN IQ - INVESTIGATION INTO POSSIBLE MECHANISMS OF ACTION FOOD AND CHEMICAL TOXICOLOGY, 30 (4). pp. 289-295.

BARNETT, CR, WILSON, J, WOLF, CR, FLATT, PR and IOANNIDES, C (1992) HYPERINSULINEMIA CAUSES A PREFERENTIAL INCREASE IN HEPATIC P4501A2 ACTIVITY BIOCHEMICAL PHARMACOLOGY, 43 (6). pp. 1255-1261.

PAPAVERGOU, E, IOANNIDES, C and CLIFFORD, MN (1992) THE EVALUATION IN THE AMES TEST OF THE MUTAGENICITY OF TETRAHYDRO-BETA-CARBOLINE-3-CARBOXYLIC ACIDS FROM SMOKED FOODS FOOD ADDITIVES AND CONTAMINANTS, 9 (2). pp. 183-187.

AYRTON, AD, NEVILLE, S and IOANNIDES, C (1992) CYTOSOLIC ACTIVATION OF 2-AMINOANTHRACENE - IMPLICATIONS IN ITS USE AS DIAGNOSTIC MUTAGEN IN THE AMES TEST MUTATION RESEARCH, 265 (1). pp. 1-8.

LEIST, M, AYRTON, AD and IOANNIDES, C (1992) A CYTOSOLIC OXYGENASE ACTIVITY INVOLVED IN THE BIOACTIVATION OF 2-AMINOFLUORENE TOXICOLOGY, 71 (1-2). pp. 7-20.

POWELL, CJ, GRASSO, P, IOANNIDES, C, WILSON, J and BRIDGES, JW (1991) HALOALKYLAMINE-INDUCED RENAL PAPILLARY NECROSIS - A HISTOPATHOLOGICAL STUDY OF STRUCTURE-ACTIVITY-RELATIONSHIPS INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 72 (6). pp. 631-646.

AYRTON, AD, IOANNIDES, C and PARKE, DV (1991) INDUCTION OF THE CYTOCHROME-P450 I-FAMILY AND IV-FAMILY AND PEROXISOMAL PROLIFERATION IN THE LIVER OF RATS TREATED WITH BENOXAPROFEN - POSSIBLE IMPLICATIONS IN ITS HEPATOTOXICITY BIOCHEMICAL PHARMACOLOGY, 42 (1). pp. 109-115.

PARKE, DV, IOANNIDES, C and LEWIS, DFV (1991) THE 1990 PHARMACEUTICAL-MANUFACTURERS-ASSOCIATION-OF-CANADA KEYNOTE LECTURE - THE ROLE OF THE CYTOCHROMES-P450 IN THE DETOXICATION AND ACTIVATION OF DRUGS AND OTHER CHEMICALS CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 69 (5). pp. 537-549.

PAPAPARASKEVA, C, IOANNIDES, C and WALKER, R (1991) AGARITINE DOES NOT MEDIATE THE MUTAGENICITY OF THE EDIBLE MUSHROOM AGARICUS-BISPORUS MUTAGENESIS, 6 (3). pp. 213-217.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1990) A RETROSPECTIVE STUDY OF THE MOLECULAR TOXICOLOGY OF BENOXAPROFEN TOXICOLOGY, 65 (1-2). pp. 33-47.

PARKE, DV, IOANNIDES, C and LEWIS, DFV (1990) THE SAFETY EVALUATION OF DRUGS AND CHEMICALS BY THE USE OF COMPUTER OPTIMIZED MOLECULAR PARAMETRIC ANALYSIS OF CHEMICAL TOXICITY (COMPACT) ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 18. pp. 91-102.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1990) A PROSPECTIVE TOXICITY EVALUATION (COMPACT) ON 40 CHEMICALS CURRENTLY BEING TESTED BY THE NATIONAL-TOXICOLOGY-PROGRAM MUTAGENESIS, 5 (5). pp. 433-435.

BARNETT, CR, FLATT, PR and IOANNIDES, C (1990) INDUCTION OF HEPATIC MICROSOMAL-P450-I AND MICROSOMAL-P450-IIB PROTEINS BY HYPERKETONEMIA BIOCHEMICAL PHARMACOLOGY, 40 (2). pp. 393-397.

BARNETT, CR, GIBSON, GG, WOLF, CR, FLATT, PR and IOANNIDES, C (1990) INDUCTION OF CYTOCHROME-P450III AND CYTOCHROME-P450IV FAMILY PROTEINS IN STREPTOZOTOCIN-INDUCED DIABETES BIOCHEMICAL JOURNAL, 268 (3). pp. 765-769.

AYRTON, AD, MCFARLANE, M, WALKER, R, NEVILLE, S and IOANNIDES, C (1990) THE INDUCTION OF P450-I PROTEINS BY AROMATIC-AMINES MAY BE RELATED TO THEIR CARCINOGENIC POTENTIAL CARCINOGENESIS, 11 (5). pp. 803-809.

IOANNIDES, C, AYRTON, AD, KEELE, A, LEWIS, DFV, FLATT, PR and WALKER, R (1990) MECHANISM OF THE INVITRO ANTIMUTAGENIC ACTION OF RETINOL MUTAGENESIS, 5 (3). pp. 257-262.

SMITH, JN, AYRTON, AD, CHOWN, J, LEWIS, DFV and IOANNIDES, C (1990) FEPRAZONE - AN INDUCER OF THE P450-II-B FAMILY OF PROTEINS IN THE RAT JOURNAL OF BIOCHEMICAL TOXICOLOGY, 5 (1). pp. 9-12.

IOANNIDES, C (1990) INDUCTION OF CYTOCHROME-P-450-I AND ITS INFLUENCES IN CHEMICAL CARCINOGENESIS BIOCHEMICAL SOCIETY TRANSACTIONS, 18 (1). pp. 32-34.

PARKE, DV, IOANNIDES, C and LEWIS, DFV (1990) COMPUTER MODELING AND INVITRO TESTS IN THE SAFETY EVALUATION OF CHEMICALS - STRATEGIC APPLICATIONS TOXICOLOGY IN VITRO, 4 (4-5). pp. 680-685.

IOANNIDES, C and PARKE, DV (1990) THE CYTOCHROME-P450-I GENE FAMILY OF MICROSOMAL HEMOPROTEINS AND THEIR ROLE IN THE METABOLIC-ACTIVATION OF CHEMICALS DRUG METABOLISM REVIEWS, 22 (1). pp. 1-85.

BARNETT, CR, FLATT, PR and IOANNIDES, C (1990) HYPERKETONEMIA MARKEDLY MODULATES THE METABOLIC-ACTIVATION OF CHEMICAL CARCINOGENS CHEMICO-BIOLOGICAL INTERACTIONS, 74 (3). pp. 281-289.

AYRTON, AD, MCFARLANE, M, WALKER, R, NEVILLE, S, COOMBS, MM and IOANNIDES, C (1990) INDUCTION OF THE P-450-I FAMILY OF PROTEINS BY POLYCYCLIC AROMATIC-HYDROCARBONS - POSSIBLE RELATIONSHIP TO THEIR CARCINOGENICITY TOXICOLOGY, 60 (1-2). pp. 173-186.

AHSING, E, POOLE, TW, IOANNIDES, C and KING, LJ (1990) MECHANISM OF THE KETOCONAZOLE-CYCLOSPORINE INTERACTION ARCHIVES OF TOXICOLOGY, 64 (6). pp. 511-513.

IOANNIDES, C (1990) METABOLISM AND TOXICITY OF CHEMICALS IN DIABETES ACTA PHARMACEUTICA JUGOSLAVICA, 40 (3). pp. 423-439.

PARKE, DV and IOANNIDES, C (1990) ROLE OF CYTOCHROMES-P-450 IN MOUSE-LIVER TUMOR PRODUCTION MOUSE LIVER CARCINOGENESIS, 331. pp. 215-230.

PARKE, DV and IOANNIDES, C (1990) THE ROLE OF METABOLISM STUDIES IN THE SAFETY EVALUATION OF NEW CHEMICALS ACTA PHARMACEUTICA JUGOSLAVICA, 40 (3). pp. 363-382.

LEWIS, DFV, RODRIGUES, AD, IOANNIDES, C and PARKE, DV (1989) ADVERSE REACTIONS OF IMIDAZOLE ANTIFUNGAL AGENTS - COMPUTER GRAPHIC STUDIES OF CYTOCHROME-P-450 INTERACTIONS JOURNAL OF BIOCHEMICAL TOXICOLOGY, 4 (4). pp. 231-234.

IOANNIDES, C, RODRIGUES, AD, AYRTON, AD, BARNETT, CR, CHOWN, J and PARKE, DV (1989) INDUCTION OF THE RAT HEPATIC-MICROSOMAL MIXED-FUNCTION OXIDASES BY CIMETIDINE TOXICOLOGY LETTERS, 49 (1). pp. 61-68.

IOANNIDES, C, LEWIS, DFV, TRINICK, J, NEVILLE, S, SERTKAYA, NN, KAJBAF, M and GORROD, JW (1989) A RATIONALE FOR THE NON-MUTAGENICITY OF 2-AMINOBIPHENYLS AND 3-AMINOBIPHENYLS CARCINOGENESIS, 10 (8). pp. 1403-1407.

RODRIGUES, AD, AYRTON, AD, WILLIAMS, EJ, LEWIS, DFV, WALKER, R and IOANNIDES, C (1989) PREFERENTIAL INDUCTION OF THE RAT HEPATIC P-450 I-PROTEINS BY THE FOOD CARCINOGEN 2-AMINO-3-METHYL-IMIDAZO[4,5-F]QUINOLINE EUROPEAN JOURNAL OF BIOCHEMISTRY, 181 (3). pp. 627-631.

AYRTON, AD, WILLIAMS, EJ, RODRIGUES, AD, IOANNIDES, C and WALKER, R (1989) THE FOOD PYROLYSIS PRODUCT IQ ENHANCES ITS OWN ACTIVATION MUTAGENESIS, 4 (3). pp. 205-207.

FLATT, PR, SHIBIER, O, IOANNIDES, C and SWANSTONFLATT, SK (1989) STUDIES ON THE CHEMICAL AND IMMUNOLOGICAL DESTRUCTION OF INSULIN-SECRETING ISLET CELL TUMORS EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY, 93 (2-3). pp. 193-202.

SEKI, H, NANNO, M, CHEN, PF, ITOH, K, IOANNIDES, C, GOOD, RA and PLATSOUCAS, CD (1989) MOLECULAR HETEROGENEITY OF GAMMA-DELTA-T-CELL ANTIGEN RECEPTORS EXPRESSED BY CD4- CD8- T-CELL CLONES FROM NORMAL DONORS - BOTH DISULFIDE-LINKED AND NON-DISULFIDE-LINKED RECEPTORS ARE DELTA-TCS1+ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 86 (7). pp. 2326-2330.

PHILLIPSON, CE and IOANNIDES, C (1989) METABOLIC-ACTIVATION OF POLYCYCLIC AROMATIC-HYDROCARBONS TO MUTAGENS IN THE AMES TEST BY VARIOUS ANIMAL SPECIES INCLUDING MAN MUTATION RESEARCH, 211 (1). pp. 147-151.

FLATT, PR, BASS, SL, AYRTON, AD, TRINICK, J and IOANNIDES, C (1989) METABOLIC-ACTIVATION OF CHEMICAL CARCINOGENS BY HEPATIC PREPARATIONS FROM STREPTOZOTOCIN-TREATED RATS DIABETOLOGIA, 32 (2). pp. 135-139.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1989) MOLECULAR-ORBITAL STUDIES OF OXYGEN ACTIVATION AND MECHANISMS OF CYTOCHROMES-P-450-MEDIATED OXIDATIVE-METABOLISM OF XENOBIOTICS CHEMICO-BIOLOGICAL INTERACTIONS, 70 (3-4). pp. 263-280.

TAYLOR, IW, IOANNIDES, C and PARKE, DV (1989) ORGANIC NITRATE REDUCTASE - REASSESSMENT OF ITS SUBCELLULAR-LOCALIZATION AND TISSUE DISTRIBUTION AND ITS RELATIONSHIP TO THE GLUTATHIONE TRANSFERASES INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 21 (1). pp. 67-71.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1989) PREDICTION OF CHEMICAL CARCINOGENICITY FROM MOLECULAR AND ELECTRONIC-STRUCTURES - A COMPARISON OF MINDO/3 AND CNDO/2 MOLECULAR-ORBITAL METHODS TOXICOLOGY LETTERS, 45 (1). pp. 1-13.

NEVILLE, S, ARENDT, J and IOANNIDES, C (1989) A STUDY OF THE MUTAGENICITY OF MELATONIN AND 6-HYDROXYMELATONIN JOURNAL OF PINEAL RESEARCH, 6 (1). pp. 73-76.

AYRTON, AD, TRINICK, J, WOOD, BP, SMITH, JN and IOANNIDES, C (1988) INDUCTION OF THE RAT HEPATIC-MICROSOMAL MIXED-FUNCTION OXIDASES BY 2 AZA-ARENES - A COMPARISON WITH THEIR NON-HETEROCYCLIC ANALOGS BIOCHEMICAL PHARMACOLOGY, 37 (23). pp. 4565-4571.

BARNETT, CR, FLATT, PR and IOANNIDES, C (1988) ROLE OF KETONE-BODIES IN THE DIABETES-INDUCED CHANGES IN HEPATIC MIXED-FUNCTION OXIDASE ACTIVITIES BIOCHIMICA ET BIOPHYSICA ACTA, 967 (2). pp. 250-254.

AYRTON, AD, IOANNIDES, C and WALKER, R (1988) INDUCTION OF RAT HEPATIC CYTOCHROME P-450-I PROTEINS BY THE ANTIMUTAGEN ANTHRAFLAVIC ACID FOOD AND CHEMICAL TOXICOLOGY, 26 (11-12). pp. 909-915.

PARKE, DV, IOANNIDES, C and LEWIS, DFV (1988) METABOLIC-ACTIVATION OF CARCINOGENS AND TOXIC-CHEMICALS HUMAN TOXICOLOGY, 7 (5). pp. 397-404.

RODRIGUES, AD, WADDELL, PR, AHSING, E, MORRIS, BA, WOLF, CR and IOANNIDES, C (1988) INDUCTION OF THE RAT HEPATIC-MICROSOMAL MIXED-FUNCTION OXIDASES BY 3-IMIDAZOLE-CONTAINING ANTIFUNGAL AGENTS - SELECTIVITY FOR THE CYTOCHROME-P-450IIB AND CYTOCHROME-P-450III FAMILIES OF CYTOCHROMES-P-450 TOXICOLOGY, 50 (3). pp. 283-301.

LEWIS, R, MACLEAN, D, IOANNIDES, C, JOHNSTON, A and MCDEVITT, DG (1988) A COMPARISON OF BISOPROLOL AND ATENOLOL IN THE TREATMENT OF MILD TO MODERATE HYPERTENSION BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 26 (1). pp. 53-59.

IOANNIDES, C, HYDE, R and SMITH, JN (1988) A COMPARISON OF AROCLOR 1254 INDUCED HEPATIC PREPARATIONS FROM RAT AND HAMSTER IN THE ACTIVATION OF PRECARCINOGENS IN THE AMES TEST MUTATION RESEARCH, 203 (3). pp. 211-212.

AYRTON, AD, IOANNIDES, C and WALKER, R (1988) ANTHRAFLAVIC ACID INHIBITS THE MUTAGENICITY OF THE FOOD MUTAGEN IQ - MECHANISM OF ACTION MUTATION RESEARCH, 207 (3-4). pp. 121-125.

AYALOGU, EO, PHILLIPSON, CE, PREECE, N, IOANNIDES, C and PARKE, DV (1988) EFFECT OF VITAMIN-A ON RAT HEPATIC MIXED-FUNCTION OXIDASES, GLUTATHIONE TRANSFERASE-ACTIVITY AND GENERATIONS OF OXYGEN RADICALS ANNALS OF NUTRITION AND METABOLISM, 32 (2). pp. 75-82.

RODRIGUES, AD, WADDELL, PR and IOANNIDES, C (1988) INHIBITION OF THE RAT HEPATIC MIXED-FUNCTION OXIDASES BY INVIVO ADMINISTRATION OF CLOTRIMAZOLE RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, 59 (3). pp. 403-406.

IOANNIDES, C, AYRTON, AD and WALKER, R (1988) THE ANTICARCINOGENICITY OF ANTHRAFLAVIC ACID ANTICANCER RESEARCH, 8 (5). p. 1078.

ABUSHAKRA, A, IOANNIDES, C and WALKER, R (1988) COMPARATIVE MUTAGENICITY STUDIES ON FRIED MINCED BEEF, GRILLED SAUSAGE AND GRILLED HAMBURGERS JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 42 (4). pp. 343-354.

IOANNIDES, C (1988) METABOLIC-ACTIVATION OF POLYCYCLIC AROMATIC-HYDROCARBONS ANTICANCER RESEARCH, 8 (5). p. 1079.

IOANNIDES, C, BASS, SL, AYRTON, AD, TRINICK, J, WALKER, R and FLATT, PR (1988) STREPTOZOTOCIN-INDUCED DIABETES MODULATES THE METABOLIC-ACTIVATION OF CHEMICAL CARCINOGENS CHEMICO-BIOLOGICAL INTERACTIONS, 68 (3-4). pp. 189-202.

AYRTON, AD, LEWIS, DFV, IOANNIDES, C and WALKER, R (1987) ANTHRAFLAVIC ACID IS A POTENT AND SPECIFIC INHIBITOR OF CYTOCHROME-P-448 ACTIVITY BIOCHIMICA ET BIOPHYSICA ACTA, 916 (3). pp. 328-331.

IOANNIDES, C and PARKE, DV (1987) THE CYTOCHROMES-P-448 - A UNIQUE FAMILY OF ENZYMES INVOLVED IN CHEMICAL TOXICITY AND CARCINOGENESIS BIOCHEMICAL PHARMACOLOGY, 36 (24). pp. 4197-4207.

RODRIGUES, AD, GIBSON, GG, IOANNIDES, C and PARKE, DV (1987) INTERACTIONS OF IMIDAZOLE ANTIFUNGAL AGENTS WITH PURIFIED CYTOCHROME-P-450 PROTEINS BIOCHEMICAL PHARMACOLOGY, 36 (24). pp. 4277-4281.

IOANNIDES, C, HYDE, R and SMITH, JN (1987) A COMPARISON OF AROCLOR 1254-INDUCED HEPATIC PREPARATIONS FROM RAT AND HAMSTER IN THE ACTIVATION OF PRECARCINOGENS IN THE AMES TEST MUTATION RESEARCH, 181 (2). p. 323.

AYRTON, AD, SMITH, JN and IOANNIDES, C (1987) BIOACTIVATION OF N-NITROSOPIPERIDINE TO MUTAGENS - ROLE OF HEPATIC CYTOCHROME-P-450 PROTEINS AND CONTRIBUTION OF CYTOSOLIC FRACTION CARCINOGENESIS, 8 (11). pp. 1691-1695.

HYDE, R, SMITH, JN and IOANNIDES, C (1987) INDUCTION OF THE HEPATIC MIXED-FUNCTION OXIDASES BY AROCHLOR-1254 IN THE HAMSTER - COMPARISON OF AROCHLOR-INDUCED RAT AND HAMSTER PREPARATIONS IN THE ACTIVATION OF PRE-CARCINOGENS IN THE AMES TEST MUTAGENESIS, 2 (6). pp. 477-482.

RODRIGUES, AD, LEWIS, DFV, IOANNIDES, C and PARKE, DV (1987) SPECTRAL AND KINETIC-STUDIES OF THE INTERACTION OF IMIDAZOLE ANTIFUNGAL AGENTS WITH MICROSOMAL CYTOCHROMES-P-450 XENOBIOTICA, 17 (11). pp. 1315-1327.

SMITH, JN and IOANNIDES, C (1987) CYTOSOLIC POTENTIATION OF THE RAT HEPATIC MICROSOME MEDIATED MUTAGENICITY OF BENZIDINE MUTAGENESIS, 2 (3). pp. 205-209.

ABUSHAKRA, A, IOANNIDES, C and WALKER, R (1987) EFFECT OF TRYPTAMINE ON THE MUTAGENIC ACTIVITY OF 2-AMINO-3-METHYLIMIDAZO(4,5-F) QUINOLINE (IQ) AND RELATED AZAARENES IN THE AMES TEST MUTAGENESIS, 2 (1). pp. 51-56.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1987) STRUCTURAL REQUIREMENTS FOR SUBSTRATES OF CYTOCHROME-P-450 AND CYTOCHROME-P-448 CHEMICO-BIOLOGICAL INTERACTIONS, 64 (1-2). pp. 39-60.

IWASAKI, K, LUM, PY, IOANNIDES, C and PARKE, DV (1986) INDUCTION OF CYTOCHROME-P-448 ACTIVITY AS EXEMPLIFIED BY THE O-DEETHYLATION OF ETHOXYRESORUFIN - EFFECTS OF DOSE, SEX, TISSUE AND ANIMAL SPECIES BIOCHEMICAL PHARMACOLOGY, 35 (21). pp. 3879-3884.

LUM, PY, BURKE, MD, MAYER, RT and IOANNIDES, C (1986) ALKOXYRESORUFIN O-DEALKYLASES - ASSOCIATION WITH THE MURINE AH LOCUS CANCER LETTERS, 32 (3). pp. 255-262.

IOANNIDES, C and STEELE, CM (1986) HEPATIC-MICROSOMAL MIXED-FUNCTION OXIDASE ACTIVITY IN ETHANOL-TREATED HAMSTERS AND ITS CONSEQUENCES ON THE BIOACTIVATION OF AROMATIC-AMINES TO MUTAGENS CHEMICO-BIOLOGICAL INTERACTIONS, 59 (2). pp. 129-139.

ABUSHAKRA, A, IOANNIDES, C and WALKER, R (1986) METABOLIC-ACTIVATION OF 2-AMINO-3-METHYLIMIDAZO(4,5-F)QUINOLINE BY HEPATIC PREPARATIONS - CONTRIBUTION OF THE CYTOSOLIC FRACTION AND ITS SIGNIFICANCE TO STRAIN DIFFERENCES MUTAGENESIS, 1 (5). pp. 367-370.

TONG, S, SMITH, J, MANSON, D, GORROD, JW and IOANNIDES, C (1986) THE METABOLIC-ACTIVATION OF 2-NAPHTHYLAMINE TO MUTAGENS IN THE AMES TEST ANTICANCER RESEARCH, 6 (5). pp. 1107-1112.

STEELE, CM and IOANNIDES, C (1986) INDUCTION OF RAT HEPATIC MIXED-FUNCTION OXIDASES BY AROMATIC-AMINES AND ITS RELATIONSHIP TO THEIR BIOACTIVATION TO MUTAGENS MUTATION RESEARCH, 162 (1). pp. 41-46.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1986) MOLECULAR DIMENSIONS OF THE SUBSTRATE BINDING-SITE OF CYTOCHROME-P-448 BIOCHEMICAL PHARMACOLOGY, 35 (13). pp. 2179-2185.

TONG, S, MASSON, HA, IOANNIDES, C, BECHTEL, WD and PARKE, DV (1986) EFFECTS OF BROTIZOLAM ON MIXED-FUNCTION OXIDASES AND GLUTATHIONE METABOLISM IN THE RAT XENOBIOTICA, 16 (6). pp. 595-604.

STEELE, CM and IOANNIDES, C (1986) DIFFERENTIAL-EFFECTS OF CHRONIC ALCOHOL ADMINISTRATION TO RATS ON THE ACTIVATION OF AROMATIC-AMINES TO MUTAGENS IN THE AMES TEST CARCINOGENESIS, 7 (5). pp. 825-829.

STEELE, CM and IOANNIDES, C (1986) EFFECT OF 2-AMINOANTHRACENE AND 4-AMINOBIPHENYL ADMINISTRATION ON THEIR ACTIVATION TO MUTAGENS AND ON RAT HEPATIC MIXED-FUNCTION OXIDASES BIOCHEMICAL SOCIETY TRANSACTIONS, 14 (1). pp. 99-100.

PARKE, DV and IOANNIDES, C (1985) CYTOCHROME-P-448 AND CHEMICAL TOXICITY JOURNAL OF HEPATOLOGY, 1 (3). S177-S177.

LUM, PY, WALKER, S and IOANNIDES, C (1985) FETAL AND NEONATAL DEVELOPMENT OF CYTOCHROME-P-450 AND CYTOCHROME-P-448 CATALYZED MIXED-FUNCTION OXIDASES IN THE RAT - INDUCTION BY 3-METHYLCHOLANTHRENE TOXICOLOGY, 35 (4). pp. 307-317.

PHILLIPSON, CE, IOANNIDES, C, BARRETT, DCA and PARKE, DV (1985) THE HOMOGENEITY OF RAT-LIVER MICROSOMAL CYTOCHROME-P-448 ACTIVITY AND ITS ROLE IN THE ACTIVATION OF BENZO[A]PYRENE TO MUTAGENS INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 17 (1). pp. 37-42.

STEELE, CM, LALIES, M and IOANNIDES, C (1985) INHIBITION OF THE MUTAGENICITY OF AROMATIC-AMINES BY THE PLANT FLAVONOID (+)-CATECHIN CANCER RESEARCH, 45 (8). pp. 3573-3577.

IOANNIDES, C, DELAFORGE, M and PARKE, DV (1985) INTERACTIONS OF SAFROLE AND ISOSAFROLE AND THEIR METABOLITES WITH CYTOCHROMES-P-450 CHEMICO-BIOLOGICAL INTERACTIONS, 53 (3). pp. 303-311.

DELAFORGE, M, IOANNIDES, C and PARKE, DV (1985) LIGAND-COMPLEX FORMATION BETWEEN CYTOCHROME-P-450 AND CYTOCHROME-P448 AND METHYLENEDIOXYPHENYL COMPOUNDS XENOBIOTICA, 15 (4). pp. 333-342.

PRATT, S and IOANNIDES, C (1985) MECHANISM OF THE PROTECTIVE ACTION OF NORMAL-ACETYLCYSTEINE AND METHIONINE AGAINST PARACETAMOL TOXICITY IN THE HAMSTER ARCHIVES OF TOXICOLOGY, 57 (3). pp. 173-177.

TONG, S, GORROD, JW and IOANNIDES, C (1985) THE METABOLIC-ACTIVATION OF 2-NAPHTHYLAMINE TO MUTAGENS IN THE AMES TEST ANTICANCER RESEARCH, 5 (6). p. 614.

PHILLIPSON, CE and IOANNIDES, C (1985) METABOLIC-ACTIVATION OF NITROSAMINES TO MUTAGENS BY VARIOUS ANIMAL SPECIES INCLUDING MAN BIOCHEMICAL PHARMACOLOGY, 34 (3). pp. 441-442.

MANNO, M, IOANNIDES, C and GIBSON, GG (1985) THE MODULATION BY ARYLAMINES OF THE INVITRO FORMATION OF SUPEROXIDE ANION RADICALS AND HYDROGEN-PEROXIDE BY RAT-LIVER MICROSOMES TOXICOLOGY LETTERS, 25 (2). pp. 121-130.

IWASAKI, K, IOANNIDES, C and PARKE, DV (1985) TISSUE AND SEX-DIFFERENCES IN BASAL AND CARCINOGEN-INDUCED ETHOXYRESORUFIN O-DE-ETHYLASE BIOCHEMICAL SOCIETY TRANSACTIONS, 13 (2). p. 357.

PARKE, DV and IOANNIDES, C (1984) ACTIVE METABOLITES IN TOXICOLOGY - THE ROLE OF CYTOCHROME-P-448 AND FLAVOPROTEIN OXIDASES ARCHIVES OF TOXICOLOGY. pp. 183-192.

MANNO, M, IOANNIDES, C and GIBSON, GG (1984) BENZIDINE MODULATES THE NADPH-DEPENDENT GENERATION OF SUPEROXIDE ANION RADICAL BY RAT-LIVER MICROSOMES HUMAN TOXICOLOGY, 3 (4). p. 335.

PHILLIPSON, CE and IOANNIDES, C (1984) A COMPARATIVE-STUDY OF THE BIOACTIVATION OF NITROSAMINES TO MUTAGENS BY VARIOUS ANIMAL SPECIES INCLUDING MAN CARCINOGENESIS, 5 (8). pp. 1091-1094.

IOANNIDES, C, LUM, PY and PARKE, DV (1984) CYTOCHROME-P-448 AND THE ACTIVATION OF TOXIC-CHEMICALS AND CARCINOGENS XENOBIOTICA, 14 (1-2). pp. 119-137.

PHILLIPSON, CE, GODDEN, PMM, LUM, PY, IOANNIDES, C and PARKE, DV (1984) DETERMINATION OF CYTOCHROME-P-448 ACTIVITY IN BIOLOGICAL TISSUES BIOCHEMICAL JOURNAL, 221 (1). pp. 81-88.

THABREW, MI and IOANNIDES, C (1984) INHIBITION OF RAT HEPATIC MIXED-FUNCTION OXIDASES BY ANTIMALARIAL-DRUGS - SELECTIVITY FOR CYTOCHROME-P-450 AND CYTOCHROME-P-448 CHEMICO-BIOLOGICAL INTERACTIONS, 51 (3). pp. 285-294.

PHILLIPSON, CE and IOANNIDES, C (1983) ACTIVATION OF AROMATIC-AMINES TO MUTAGENS BY VARIOUS ANIMAL SPECIES INCLUDING MAN MUTATION RESEARCH, 124 (3-4). pp. 325-336.

WALKER, R, MENDOZAGARCIA, MA, IOANNIDES, C and QUATTRUCCI, E (1983) ACUTE TOXICITY OF 3-DEOXY-4-SULFOHEXOSULOSE IN RATS AND MICE, AND INVITRO MUTAGENICITY IN THE AMES TEST FOOD AND CHEMICAL TOXICOLOGY, 21 (3). pp. 299-303.

IOANNIDES, C, HALL, DE, MULDER, DE, STEELE, CM, SPICKETT, J, DELAFORGE, M and PARKE, DV (1983) A COMPARISON OF THE PROTECTIVE EFFECTS OF N-ACETYLCYSTEINE AND S-CARBOXYMETHYLCYSTEINE AGAINST PARACETAMOL-INDUCED HEPATOTOXICITY TOXICOLOGY, 28 (4). pp. 313-321.

TAYLOR, IW, IOANNIDES, C, SACRA, P, TURNER, JC and PARKE, DV (1983) EFFECT OF DEUTERATION OF IMIPRAMINE ON ITS PHARMACOKINETIC PROPERTIES IN THE RAT BIOCHEMICAL PHARMACOLOGY, 32 (4). pp. 641-647.

OKINE, LKN, IOANNIDES, C and PARKE, DV (1983) EFFECT OF SOME BETA-ADRENERGIC BLOCKING-AGENTS ON TISSUE GUANYLATE-CYCLASE AND CYCLIC-NUCLEOTIDES IN THE RAT TOXICOLOGY LETTERS, 18 (3). pp. 235-240.

STEELE, CM, MASSON, HA, BATTERSHILL, JM, GIBSON, GG and IOANNIDES, C (1983) METABOLIC-ACTIVATION OF PARACETAMOL BY HIGHLY PURIFIED FORMS OF CYTOCHROME-P-450 RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, 40 (1). pp. 109-119.

JONES, RS, ALI, M, IOANNIDES, C, STYLES, JA, ASHBY, J, SULEJ, J and PARKE, DV (1983) THE MUTAGENIC AND CELL TRANSFORMING PROPERTIES OF SHIKIMIC ACID AND SOME OF ITS BACTERIAL AND MAMMALIAN METABOLITES TOXICOLOGY LETTERS, 19 (1-2). pp. 43-50.

MASSON, HA, IOANNIDES, C, GORROD, JW and GIBSON, GG (1983) THE ROLE OF HIGHLY PURIFIED CYTOCHROME-P-450 ISOZYMES IN THE ACTIVATION OF 4-AMINOBIPHENYL TO MUTAGENIC PRODUCTS IN THE AMES TEST CARCINOGENESIS, 4 (12). pp. 1583-1586.

MASSON, HA, IOANNIDES, C and GIBSON, GG (1983) THE ROLE OF HIGHLY PURIFIED FORMS OF RAT-LIVER CYTOCHROME-P-450 IN THE DEMETHYLATION OF DIMETHYLNITROSAMINE AND ITS ACTIVATION TO MUTAGENS TOXICOLOGY LETTERS, 17 (1-2). pp. 131-135.

IOANNIDES, C, STEELE, CM and PARKE, DV (1983) SPECIES VARIATION IN THE METABOLIC-ACTIVATION OF PARACETAMOL TO TOXIC INTERMEDIATES - ROLE OF CYTOCHROME-P-450 AND CYTOCHROME-P-448 TOXICOLOGY LETTERS, 16 (1-2). pp. 55-61.

OKINE, LKN, IOANNIDES, C and PARKE, DV (1983) STUDIES ON THE POSSIBLE MUTAGENICITY OF BETA-ADRENERGIC BLOCKER DRUGS TOXICOLOGY LETTERS, 16 (3-4). pp. 167-174.

IOANNIDES, C, PARKE, DV and TAYLOR, IW (1982) ELIMINATION OF GLYCERYL TRINITRATE - EFFECTS OF SEX, AGE, SPECIES AND ROUTE OF ADMINISTRATION BRITISH JOURNAL OF PHARMACOLOGY, 77 (1). pp. 83-88.

IOANNIDES, C, STONE, AN, BREACKER, PJ and BASU, TK (1982) IMPAIRMENT OF ABSORPTION OF ASCORBIC-ACID FOLLOWING INGESTION OF ASPIRIN IN GUINEA-PIGS BIOCHEMICAL PHARMACOLOGY, 31 (24). pp. 4035-4038.

OKINE, LKNA, IOANNIDES, C and PARKE, DV (1982) INHIBITION OF GASTROINTESTINAL MUCOSAL GLYCOPROTEIN-SYNTHESIS BY THE BETA-ADRENERGIC BLOCKING DRUG, PRACTOLOL BIOCHEMICAL PHARMACOLOGY, 31 (13). pp. 2263-2266.

PHILLIPSON, CE, IOANNIDES, C and PARKE, DV (1982) METABOLIC-ACTIVATION OF DIMETHYLNITROSAMINE TO MUTAGENS - ROLE OF CYTOCHROMES P-450 AND P-448 TOXICOLOGY LETTERS, 11 (1-2). pp. 95-101.

PHILLIPSON, CE, GODDEN, PMM, IOANNIDES, C and PARKE, DV (1982) THE MUTAGENICITY OF 9-HYDROXYELLIPTICINE AND ITS INDUCTION OF CYTOCHROME P-448 ACTIVITY IN RAT-LIVER MICROSOMES CARCINOGENESIS, 3 (10). pp. 1179-1182.

PARKE, DV and IOANNIDES, C (1982) ROLE OF MIXED-FUNCTION OXIDASES IN THE FORMATION OF BIOLOGICAL REACTIVE INTERMEDIATES ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, 136. pp. 23-38.

DELAFORGE, M, IOANNIDES, C and PARKE, DV (1982) SELECTIVE-INHIBITION OF THE SAFROLE-INDUCED MIXED-FUNCTION OXIDASE ACTIVITIES BY 9-HYDROXYELLIPTICINE CHEMICO-BIOLOGICAL INTERACTIONS, 42 (3). pp. 279-289.

PHILLIPSON, CE, IOANNIDES, C, DELAFORGE, M and PARKE, DV (1982) STUDIES ON THE SUBSTRATE-BINDING SITES OF LIVER MICROSOMAL CYTOCHROME P-448 BIOCHEMICAL JOURNAL, 207 (1). pp. 51-56.

IOANNIDES, C, PARKINSON, C and PARKE, DV (1981) ACTIVATION OF BENZO(A)PYRENE AND 2-ACETAMIDOFLUORENE TO MUTAGENS BY MICROSOMAL PREPARATIONS FROM DIFFERENT ANIMAL SPECIES - ROLE OF CYTOCHROME-P-450 AND P-448 XENOBIOTICA, 11 (10). pp. 701-708.

TAYLOR, IW, IOANNIDES, C, TURNER, JC, KOENIGSBERGER, RU and PARKE, DV (1981) MICRO-DETERMINATION OF GLYCERYL TRINITRATE IN BIOLOGICAL-FLUIDS - EFFECT OF DEUTERATION OF GLYCERYL TRINITRATE ON ITS PHARMACOKINETIC PROPERTIES JOURNAL OF PHARMACY AND PHARMACOLOGY, 33 (4). pp. 244-246.

PARKE, DV and IOANNIDES, C (1981) THE ROLE OF NUTRITION IN TOXICOLOGY ANNUAL REVIEW OF NUTRITION, 1. pp. 207-234.

IOANNIDES, C, DELAFORGE, M and PARKE, DV (1981) SAFROLE - ITS METABOLISM, CARCINOGENICITY AND INTERACTIONS WITH CYTOCHROME-P-450 FOOD AND COSMETICS TOXICOLOGY, 19 (5). pp. 657-666.

DELAFORGE, M, IOANNIDES, C and PARKE, DV (1980) INHIBITION OF CYTOCHROME P-448 MIXED-FUNCTION OXIDASE ACTIVITY FOLLOWING ADMINISTRATION OF 9-HYDROXYELLIPTICINE TO RATS CHEMICO-BIOLOGICAL INTERACTIONS, 32 (1-2). pp. 101-110.

IOANNIDES, C and PARKE, DV (1980) THE METABOLIC ACTIVATION AND DETOXICATION OF MUTAGENS AND CARCINOGENS CHEMISTRY & INDUSTRY (21). pp. 854-859.

JONES, RS, ALI, M, SULEJ, J, IOANNIDES, C and PARKE, DV (1980) MUTAGENICITY OF SHIKIMATE AND ITS METABOLITES TOXICOLOGY LETTERS. p. 254.

IOANNIDES, C (1979) EFFECT OF DIET ON THE METABOLISM AND TOXICOLOGY OF DRUGS JOURNAL OF HUMAN NUTRITION, 33 (5). pp. 357-366.

IOANNIDES, C, OKINE, L and PARKE, DV (1979) EFFECTS OF BETA-ADRENOCEPTOR ANTAGONISTS ON THE HEPATIC MIXED-FUNCTION OXYGENASES IN THE RAT BRITISH JOURNAL OF PHARMACOLOGY, 67 (3). P451-P452.

IOANNIDES, C, SWEATMAN, B, RICHARDS, R and PARKE, DV (1977) DRUG-METABOLISM IN FERRET - EFFECTS OF AGE, SEX AND STRAIN GENERAL PHARMACOLOGY, 8 (4). pp. 243-249.

TONG, S, IOANNIDES, C and PARKE, DV (1977) ENHANCEMENT OF 2-HYDROXYLATION INVITRO OF BIPHENYL BY ORGANOCHLORINE INSECTICIDES BIOCHEMICAL SOCIETY TRANSACTIONS, 5 (5). pp. 1374-1377.

TONG, S, IOANNIDES, C and PARKE, DV (1977) POSSIBLE PITFALLS OF BIPHENYL TEST FOR CHEMICAL CARCINOGENS BIOCHEMICAL SOCIETY TRANSACTIONS, 5 (5). pp. 1372-1374.

IOANNIDES, C and PARKE, DV (1976) EFFECT OF ALLYL COMPOUNDS ON HEPATIC MICROSOMAL MIXED-FUNCTION OXIDATION AND PORPHYROGENESIS CHEMICO-BIOLOGICAL INTERACTIONS, 14 (3-4). pp. 241-249.

IOANNIDES, C, LAKE, BG and PARKE, DV (1975) ENHANCEMENT OF HEPATIC MICROSOMAL DRUG-METABOLISM INVITRO FOLLOWING ETHANOL ADMINISTRATION XENOBIOTICA, 5 (11). pp. 665-676.

IOANNIDES, C and PARKE, DV (1975) MECHANISM OF INDUCTION OF HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES BY A SERIES OF BARBITURATES JOURNAL OF PHARMACY AND PHARMACOLOGY, 27 (10). pp. 739-746.

IOANNIDES, C and KIBURIS, J (1975) METABOLISM OF PRENAZONE PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 7 (6). pp. 521-526.

Conference or Workshop Item

BARNETT, CR, FLATT, PR, BONE, AJ and IOANNIDES, C (1994) HEPATIC CYTOCHROME-P450 PROFILE IN BB RATS WITH SPONTANEOUS INSULIN-DEPENDENT DIABETES-MELLITUS In: 8th International Conference on Cytochrome P450: Biochemistry, Biophysics and Molecular Biology, 1993-10-24 - 1993-10-28, CALOUSTE GULBENKIAN FDN, LISBON, PORTUGAL.

WALKER, R, AYRTON, AD and IOANNIDES, C (1993) POTENTIAL ANTI-MUTAGENICITY AND ANTI-CARCINOGENICITY OF SOME PLANT PHENOLS In: International Conference on Food and Cancer Prevention: Chemical and Biological Aspects, 1992-09-12 - 1992-09-16, NORWICH, UNITED KINGDOM.

LEWIS, DFV, IOANNIDES, C and PARKE, DV (1993) PREDICTION OF THE CARCINOGENIC POTENTIAL BY COMPUTER-OPTIMIZED MOLECULAR PARAMETRIC ANALYSIS OF CHEMICAL TOXICITY (COMPACT) VIA CYTOCHROME-P450 INTERACTIONS In: 13TH INTERNATIONAL SYMP ON POLYNUCLEAR AROMATIC HYDROCARBONS ( PAH 13 ), 1991-10-01 - 1991-10-04, BORDEAUX, FRANCE.

IOANNIDES, C, RODRIGUES, AD, AYRTON, AD, WILLIAMS, EJ, NEVILLE, S and WALKER, R (1989) IQ SELECTIVELY INDUCES CYTOCHROME-P-450I PROTEINS AND STIMULATES ITS OWN ACTIVATION In: 6TH INTERNATIONAL CONF ON BIOCHEMISTRY AND BIOPHYSICS OF CYTOCHROME P-450, 1988-07-03 - 1988-07-08, UNIV ECON, VIENNA, AUSTRIA.

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