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Rajani, K, Parrish, C, Kottke, T, Thompson, J, Zaidi, S, Ilett, L, Shim, KG, Diaz, R-M, Pandha, H, Harrington, K, Coffey, M, Melcher, A and Vile, R (2016) Combination Therapy With Reovirus and Anti-PD-1 Blockade Controls Tumor Growth Through Innate and Adaptive Immune Responses MOLECULAR THERAPY, 24 (1). pp. 166-174.

Roulstone, V, Pedersen, M, Kyula, J, Mansfield, D, Khan, AA, McEntee, G, Wilkinson, M, Karapanagiotou, E, Coffey, M, Marais, R, Jebar, A, Errington-Mais, F, Melcher, A, Vile, R, Pandha, H, McLaughlin, M and Harrington, KJ (2015) BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress MOLECULAR THERAPY, 23 (5). pp. 931-942.

Roulstone, V, Khan, K, Pandha, HS, Rudman, S, Coffey, M, Gill, GM, Melcher, AA, Vile, R, Harrington, KJ, de Bono, J and Spicer, J (2015) Phase I Trial of Cyclophosphamide as an Immune Modulator for Optimizing Oncolytic Reovirus Delivery to Solid Tumors CLINICAL CANCER RESEARCH, 21 (6). pp. 1305-1312.

Ilett, E, Kottke, T, Donnelly, O, Thompson, J, Willmon, C, Diaz, R, Zaidi, S, Coffey, M, Selby, P, Harrington, K, Pandha, H, Melcher, A and Vile, R (2014) Cytokine Conditioning Enhances Systemic Delivery and Therapy of an Oncolytic Virus MOLECULAR THERAPY, 22 (10). pp. 1851-1863.

Jennings, VA, Ilett, EJ, Scott, KJ, West, EJ, Vile, R, Pandha, H, Harrington, K, Young, A, Hall, GD, Coffey, M, Selby, P, Errington-Mais, F and Melcher, AA (2014) Lymphokine-activated killer and dendritic cell carriage enhances oncolytic reovirus therapy for ovarian cancer by overcoming antibody neutralization in ascites INTERNATIONAL JOURNAL OF CANCER, 134 (5). pp. 1091-1101.

Kottke, T, Boisgerault, N, Diaz, RM, Donnelly, O, Rommelfanger-Konkol, D, Pulido, J, Thompson, J, Mukhopadhyay, D, Kaspar, R, Coffey, M, Pandha, H, Melcher, A, Harrington, K, Selby, P and Vile, R (2013) Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence NATURE MEDICINE, 19 (12). pp. 1625-1631.

Adair, RA, Scott, KJ, Fraser, S, Errington-Mais, F, Pandha, H, Coffey, M, Selby, P, Cook, GP, Vile, R, Harrington, KJ, Toogood, G and Melcher, AA (2012) Cytotoxic and immune-mediated killing of human colorectal cancer by reovirus-loaded blood and liver mononuclear cells. Int J Cancer.

Roulstone, V, Twigger, K, Zaidi, S, Pencavel, T, Kyula, JN, White, C, McLaughlin, M, Seth, R, Karapanagiotou, EM, Mansfield, D, Coffey, M, Nuovo, G, Vile, RG, Pandha, HS, Melcher, AA and Harrington, KJ (2012) Synergistic cytotoxicity of oncolytic reovirus in combination with cisplatin-paclitaxel doublet chemotherapy. Gene Ther.

Adair, RA, Roulstone, V, Scott, KJ, Morgan, R, Nuovo, GJ, Fuller, M, Beirne, D, West, EJ, Jennings, VA, Rose, A, Kyula, J, Fraser, S, Dave, R, Anthoney, DA, Merrick, A, Prestwich, R, Aldouri, A, Donnelly, O, Pandha, H, Coffey, M, Selby, P, Vile, R, Toogood, G, Harrington, K and Melcher, AA (2012) Cell carriage, delivery, and selective replication of an oncolytic virus in tumor in patients. Sci Transl Med, 4 (138).

Karapanagiotou, EM, Roulstone, V, Twigger, K, Ball, M, Tanay, M, Nutting, C, Newbold, K, Gore, ME, Larkin, J, Syrigos, KN, Coffey, M, Thompson, B, Mettinger, K, Vile, RG, Pandha, HS, Hall, GD, Melcher, AA, Chester, J and Harrington, KJ (2012) Phase I/II Trial of Carboplatin and Paclitaxel Chemotherapy in Combination with Intravenous Oncolytic Reovirus in Patients with Advanced Malignancies CLINICAL CANCER RESEARCH, 18 (7). pp. 2080-2089.

Hall, K, Scott, KJ, Rose, A, Desborough, M, Harrington, K, Pandha, H, Parrish, C, Vile, R, Coffey, M, Bowen, D, Errington-Mais, F and Melcher, AA (2012) Reovirus-mediated cytotoxicity and enhancement of innate immune responses against acute myeloid leukemia. Biores Open Access, 1 (1). pp. 3-15.

Twigger, K, Roulstone, V, Kyula, J, Karapanagiotou, EM, Syrigos, KN, Morgan, R, White, C, Bhide, S, Nuovo, G, Coffey, M, Thompson, B, Jebar, A, Errington, F, Melcher, AA, Vile, RG, Pandha, HS and Harrington, KJ (2012) Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway. BMC Cancer, 12.

Kottke, T, Chester, J, Ilett, E, Thompson, J, Diaz, R, Coffey, M, Selby, P, Nuovo, G, Pulido, J and Mukhopadhyay, D (2011) Precise scheduling of chemotherapy primes VEGF-producing tumors for successful systemic oncolytic virotherapy. Mol Ther, 19 (10). pp. 1802-1812.

Ilett, EJ, Barcena, M, Errington-Mais, F, Griffin, S, Harrington, KJ, Pandha, HS, Coffey, M, Selby, PJ, Limpens, RWAL, Mommaas, M, Hoeben, RC, Vile, RG and Melcher, AA (2011) Internalization of Oncolytic Reovirus by Human Dendritic Cell Carriers Protects the Virus from Neutralization CLINICAL CANCER RESEARCH, 17 (9). pp. 2767-2776.

Steele, L, Errington, F, Prestwich, R, Ilett, E, Harrington, K, Pandha, H, Coffey, M, Selby, P, Vile, R and Melcher, A (2011) Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-kappa B mediated and supports innate and adaptive anti-tumour immune priming MOLECULAR CANCER, 10, ARTN 20.

Comins, C, Spicer, J, Protheroe, A, Roulstone, V, Twigger, K, White, CM, Vile, R, Melcher, A, Coffey, MC, Mettinger, KL, Nuovo, G, Cohn, DE, Phelps, M, Harrington, KJ and Pandha, HS (2010) REO-10: A Phase I Study of Intravenous Reovirus and Docetaxel in Patients with Advanced Cancer CLINICAL CANCER RESEARCH, 16 (22). pp. 5564-5572.

Harrington, KJ, Karapanagiotou, EM, Roulstone, V, Twigger, KR, White, CL, Vidal, L, Beirne, D, Prestwich, R, Newbold, K, Ahmed, M, Thway, K, Nutting, CM, Coffey, M, Harris, D, Vile, RG, Pandha, HS, DeBono, JS and Melcher, AA (2010) Two-Stage Phase I Dose-Escalation Study of Intratumoral Reovirus Type 3 Dearing and Palliative Radiotherapy in Patients with Advanced Cancers CLINICAL CANCER RESEARCH, 16 (11). pp. 3067-3077.

Karapanagiotou, EM, Chester, JD, Pandha, HS, Gill, GM, Coffey, MC, Mettinger, K and Harrington, KJ (2010) A phase I/II study of oncolytic reovirus plus carboplatin/paclitaxel in patients with advanced solid cancers with emphasis on squamous cell carcinoma of the head and neck(SCCHN) JOURNAL OF CLINICAL ONCOLOGY, 28 (15).

Kottke, T, Hall, G, Pulido, J, Diaz, RM, Thompson, J, Chong, H, Selby, P, Coffey, M, Pandha, H, Chester, J, Melcher, A, Harrington, K and Vile, R (2010) Antiangiogenic cancer therapy combined with oncolytic virotherapy leads to regression of established tumors in mice JOURNAL OF CLINICAL INVESTIGATION, 120 (5). pp. 1551-1560.

Pandha, Hardev, Heinemann, Lucy, Simpson, Guy, Melcher, A, Prestwich, R, Errington, F, Coffey, M, Harrington, KJ and Morgan, Richard (2009) Synergistic Effects of Oncolytic Reovirus and Cisplatin Chemotherapy in Murine Malignant Melanoma Clinical Cancer Research, 15 (19). pp. 6158-6166.

Ilett, EJ, Prestwich, RJ, Kottke, T, Errington, F, Thompson, JM, Harrington, KJ, Pandha, HS, Coffey, M, Selby, PJ, Vile, RG and Melcher, AA (2009) Dendritic cells and T cells deliver oncolytic reovirus for tumour killing despite pre-existing anti-viral immunity GENE THERAPY, 16 (5). pp. 689-699.

Maskrey, BH, Bermúdez-Fajardo, A, Morgan, AH, Stewart-Jones, E, Dioszeghy, V, Taylor, GW, Baker, PRS, Coles, B, Coffey, MJ, Kühn, H and O'Donnell, VB (2009) Erratum: Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase (Journal of Biological Chemistry (2007) vol. 282 (20151-20163)) Journal of Biological Chemistry, 284 (37). p. 25460.

Vidal, L, Pandha, HS, Yap, TA, White, CL, Twigger, K, Vile, RG, Melcher, A, Coffey, M, Harrington, KJ and DeBono, JS (2008) A Phase I Study of Intravenous Oncolytic Reovirus Type 3 Dearing in Patients with Advanced Cancer CLINICAL CANCER RESEARCH, 14 (21). pp. 7127-7137.

Errington, F, White, CL, Twigger, KR, Rose, A, Scott, K, Steele, L, Ilett, LJ, Prestwich, R, Pandha, HS, Coffey, M, Selby, P, Vile, R, Harrington, KJ and Melcher, AA (2008) Inflammatory tumour cell killing by oncolytic reovirus for the treatment of melanoma GENE THERAPY, 15 (18). pp. 1257-1270.

White, CL, Twigger, KR, Vidal, L, De Bono, JS, Coffey, M, Heinemann, L, Morgan, R, Merrick, A, Errington, F, Vile, RG, Melcher, AA, Pandha, HS and Harrington, KJ (2008) Characterization of the adaptive and innate immune response to intravenous oncolytic reovirus (Dearing type 3) during a phase I clinical trial GENE THERAPY, 15 (12). pp. 911-920.

Errington, F, Steele, L, Prestwich, R, Harrington, KJ, Pandha, HS, Vidal, L, de Bono, J, Selby, P, Coffey, M, Vile, R and Melcher, A (2008) Reovirus activates human dendritic cells to promote innate antitumor immunity JOURNAL OF IMMUNOLOGY, 180 (9). pp. 6018-6026.

Twigger, K, Vidal, L, White, CL, De Bono, JS, Bhide, S, Coffey, M, Thompson, B, Vile, RG, Heinemann, L, Pandha, HS, Errington, F, Melcher, AA and Harrington, KJ (2008) Enhanced in vitro and in vivo cytotoxicity of combined reovirus and radiotherapy CLINICAL CANCER RESEARCH, 14 (3). pp. 912-923.

Qiao, J, Wang, H, Kottke, T, White, C, Twigger, K, Diaz, RM, Thompson, J, Selby, P, de Bono, J, Melcher, A, Pandha, H, Coffey, M, Vile, R and Harrington, K (2008) Cyclophosphamide facilitates antitumor efficacy against subcutaneous tumors following intravenous delivery of reovirus CLINICAL CANCER RESEARCH, 14 (1). pp. 259-269.

Harris, D, Vidal, L, Melcher, A, Newbold, K, Anthony, A, Karavasilis, V, Agarwal, R, White, C, Twigger, K, Coffey, M, Mettinger, K, Thompson, B, Pandha, H, De-Bono, J and Harrington, K (2007) A Phase I study to evaluate the feasibility, safety and biological effects of intratumoural administration of wild-type Reovirus (REOLYSIN (R)) in combination with radiation in patients with advanced malignancies. MOLECULAR CANCER THERAPEUTICS, 6 (12). 3458S-3458S.

Maskrey, BH, Bermudez-Fajardo, A, Morgan, AH, Stewart-Jones, E, Dioszeghy, V, Taylor, GW, Baker, PRS, Coles, B, Coffey, MJ, Kuehn, H and O'Donnell, VB (2007) Activated platelets and monocytes generate four hydroxyphosphatidylethanolamines via lipoxygenase JOURNAL OF BIOLOGICAL CHEMISTRY, 282 (28). pp. 20151-20163.

Yap, TA, Vidal, L, Pandha, H, Spicer, J, Digue, L, Coffey, M, Thompson, B, Kaye, SB, Harrington, KJ and De-Bono, JS (2006) A phase I study of wild-type reovirus, which selectively replicates in cells expressing activated Ras, administered intravenously to patients with advanced cancer EJC SUPPLEMENTS, 4 (12). p. 108.

Coffey, MJ, Coles, B, Locke, M, Bermudez-Fajardo, A, Williams, PC, Jarvis, GE and O'Donnell, VB (2004) Interactions of 12-lipoxygenase with phospholipase A(2) isoforms following platelet activation through the glycoprotein VI collagen receptor FEBS LETTERS, 576 (1-2). pp. 165-168.

Conference or Workshop Item

Rajani, K, Shim, K, Parrish, C, Ilett, L, Kottke, T, Pulido, J, Thompson, J, Pandha, H, Harrington, K, Melcher, A, Errington, F, Diaz, R, Coffey, M, Zaidi, S and Vile, R (2015) Combination Therapy of Reovirus and PD-1 Blockade Effectively Establishes Tumor Control Via Innate and Adaptive Immune Responses In: 18th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), 2015-05-13 - 2015-05-16, New Orleans, LA.

Jebar, A, Bentham, M, Errington-Mais, F, Scott, K, Peckham-Cooper, A, Dave, R, Toogood, G, Swinson, D, Ralph, C, Anthoney, A, Coffey, M, Harrington, K, Pandha, H, Vile, R, Selby, P, Melcher, A and Griffin, S (2014) Combined anti-viral and anti-tumour therapy for virus-associated liver cancer In: 8th International Conference on Oncolytic Virus Therapeutics, 2014-04-10 - 2014-04-13, Lincoln Coll & Examinat Sch, Oxford, ENGLAND.

Bolton, GC, Simpson, GR, Coffey, M, Harrington, K, Morgan, R, Annels, N, Launchbury, FA, Ajaz, M and Pandha, H (2014) Resistance to Oncolytic Reovirus is associated with high expression of Yes-Associated Protein-1 (YAP-1) in Head and Neck Cancer In: 8th International Conference on Oncolytic Virus Therapeutics, 2014-04-10 - 2014-04-13, Lincoln Coll & Examinat Sch, Oxford, ENGLAND.

Jebar, A, West, E, Scott, K, Thomson, S, Corns, R, Coffey, MC, Rose, A, Nuovo, G, Ryan, M, Errington-Mais, F, Ralph, C, Twelves, C, Griffin, S, Harrington, KJ, Pandha, HS, Donnely, O, Selby, PJ, Vile, R, Short, S and Melcher, A (2014) Oncolytic wild-type reovirus infection in brain tumors following intravenous administration in patients. In: 50th Annual Meeting of the American-Society-of-Clinical-Oncology, 2014-05-30 - 2014-06-03, Chicago, IL.

Ilett, E, Kottke, T, Donnelly, O, Thompson, J, Willmon, C, Diaz, R, Zaidi, S, Coffey, M, Selby, P, Harrington, K, Pandha, H, Melcher, A and Vile, R (2014) Direct, Cytokine-Conditioned, In Vivo Cell Loading for Systemic Delivery of Oncolytic Viruses In: 17th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), 2014-05-21 - 2014-05-24, Washington, DC.

Kottke, T, Donnelly, O, Ilett, E, Thompson, J, Diaz, R, Coffey, M, Selby, P, Pandha, H, Harrington, K, Melcher, A and Vile, R (2013) In Vivo Expansion of a Recipient Population of Cell Carriers Allows for Highly Effective Systemic Delivery of Oncolytic Reovirus Even in the Presence of Neutralizing Antibody In: 16th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), 2013-05-15 - 2013-05-18, Salt Lake City, UT.

Kottke, T, Donnelly, O, Boisgerault, N, Diaz, R, Rommelfanger-Konkol, D, Pulido, J, Thompson, J, Mukhopadhyay, D, Knutson, K, Behrens, M, Kaspar, R, Coffey, M, Selby, P, Harrington, K, Melcher, A, Pandha, H and Vile, R (2013) Tumor Relapse Is Associated with an Innate Immune Resistant Phenotype across Tumor and Treatment Types Which Can Be Targeted with Rational Second Line Therapies In: 16th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), 2013-05-15 - 2013-05-18, Salt Lake City, UT.

Karapanagiotou, E, Pandha, HS, Hall, G, Chester, J, Melcher, A, Coffey, M, de Bono, J, Gore, ME, Nutting, CM and Harrington, KJ (2009) Phase I/II trial of oncolytic reovirus (Reolysin) in combination with carboplatin/paclitaxel in patients (pts) with advanced solid cancers In: 45th Annual Meeting of the American-Society-of-Clinical-Oncology, 2009-05-29 - 2009-06-02, Orlando, FL.

Rudman, SM, Comins, C, Mukherji, D, Coffey, M, Mettinger, K, Protheroe, A, Harrington, KJ, Pandha, H and Spicer, JF (2009) Results of a phase I study to evaluate the feasibility, safety, and biological effects of intravenous administration of wild-type reovirus with docetaxel to patients with advanced malignancies In: 45th Annual Meeting of the American-Society-of-Clinical-Oncology, 2009-05-29 - 2009-06-02, Orlando, FL.

Comins, C, Spicer, J, Protheroe, A, Mukherji, D, Coffey, M, Thompson, B, Harrington, K and Pandha, H (2008) A Phase I Study to Evaluate Systemic Wild-type Reovirus (REOLYSIN)(R) in Combination With Docetaxel in Patients With Advanced Malignancies In: 23rd Annual Scientific Meeting of the International-Society-for-Biological-Therapy-of-Cancer, 2008-10-31 - 2008-11-02, San Diego, CA.

Heinemann, L, Kottke, T, Vile, R, Coffey, MC, Harrington, K, Melcher, A and Pandha, HS (2008) Synergistic Anti-Tumor Activity of Oncolytic Reovirus and Docetaxel in a PC-3 Prostate Cancer Mouse Model In: 23rd Annual Scientific Meeting of the International-Society-for-Biological-Therapy-of-Cancer, 2008-10-31 - 2008-11-02, San Diego, CA.

Heinemann, L, Simpson, G, Harrington, K, Melcher, A, Coffey, MC and Pandha, HS (2008) Synergistic anti-tumour activity of oncolytic Reovirus and cisplatin in a B16.F10 mouse melanoma model In: 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, 2008-10-21 - 2008-10-24, Geneva, SWITZERLAND.

Vidal, L, Pandha, H, Spicer, J, Harrington, KJ, Allen, S, Leader, D, Coffey, M, Thompson, B, Kaye, S and De-Bono, J (2006) A phase I study of reolysin given intravenously to patients with advanced malignancies. In: 42nd Annual Meeting of the American-Society-of-Clinical-Oncology, 2006-06-02 - 2006-06-06, Atlanta, GA.

Maskrey, B, Bermudez-Fajardo, A, Stewart-Jones, E, Dioszeghy, V, Taylor, GW, Baker, PRS, Coles, B, Coffey, MJ, Kuehn, H and O'Donnell, VB (2006) Endogenous generation of phosphatidylethanol-amine-esterified lipoxygenase products in monocytes and platelets In: 13th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine, 2006-11-15 - 2006-11-19, Denver, CO.

Vidal, L, Twigger, K, White, C, Coffey, M, Thompson, B, De-Bono, J, Pandha, HS, Melcher, A, Kaye, S and Harrington, KJ (2005) Reovirus enhances radiation cytotoxicity in vitro and in vivo. In: AACR/NCI/EORTC International Conference on Molecular Targets and Cancer Therapeutics, 2005-11-14 - 2005-11-18, Philadelphia, PA.

Vidal, L, Pandha, H, Harrington, K, Fong, P, Shaw, H, Barrett, M, Leader, D, White, C, Twigger, K, Coffey, M, Thompson, B, Kaye, S and De-Bono, J (2005) A phase I study of a wild-type reovirus (Reolysin) given intravenously to patients with advanced malignancies. In: AACR/NCI/EORTC International Conference on Molecular Targets and Cancer Therapeutics, 2005-11-14 - 2005-11-18, Philadelphia, PA.

Maskrey, B, Bermudez-Fajardo, A, Coffey, M, Coles, B, Kuhn, H and O'Donnell, V (2005) Generation of predominantly esterified 15S-and 12S-H(P)ETE by murine and human 12/15-lipoxygenases in leukocytes In: 12th Annual Meeting Society-for-Free-Radical-Biology-and-Medicine, 2005-11-16 - 2005-11-20, Austin, TX.

Bermudez, AF, Coles, B, Coffey, M and O'Donnell, V (2003) Protein kinase C regulates 15-lipoxygenase oxidation of membrane-bound arachidonate in human monocytes In: 10th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicne, 2003-11-20 - 2003-11-24, SEATTLE, WASHINGTON.

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