A model for the accidental catalysis of protein unfolding in vivo
Sear, RP (2004) A model for the accidental catalysis of protein unfolding in vivo EPL (Europhysics Letters) . (Unpublished)
Activated processes such as protein unfolding are highly sensitive to heterogeneity in the environment. We study a highly simplified model of a protein in a random heterogeneous environment, a model of the in vivo environment. It is found that if the heterogeneity is sufficiently large, the total rate of the process is essentially a random variable; this may be the cause of the species-to-species variability in the rate of prion protein conversion found by Deleault et al.
|Divisions:||Faculty of Engineering and Physical Sciences > Physics|
|Deposited By:||Mr Adam Field|
|Deposited On:||27 May 2010 15:06|
|Last Modified:||20 Sep 2012 13:19|
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