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A model for the accidental catalysis of protein unfolding in vivo

Sear, RP (2004) A model for the accidental catalysis of protein unfolding in vivo EPL (Europhysics Letters). (Unpublished)

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Abstract

Activated processes such as protein unfolding are highly sensitive to heterogeneity in the environment. We study a highly simplified model of a protein in a random heterogeneous environment, a model of the in vivo environment. It is found that if the heterogeneity is sufficiently large, the total rate of the process is essentially a random variable; this may be the cause of the species-to-species variability in the rate of prion protein conversion found by Deleault et al.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Physics
Authors :
AuthorsEmail
Sear, RPUNSPECIFIED
Date : 21 September 2004
Identification Number : 10.1209/epl/i2004-10249-7
Related URLs :
Depositing User : Mr Adam Field
Date Deposited : 27 May 2010 14:06
Last Modified : 23 Sep 2013 18:25
URI: http://epubs.surrey.ac.uk/id/eprint/94

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