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Observations of coarsening of air voids in a polymer-highly-soluble crystalline matrix during dissolution

Karakosta, E, Jenneson, PM, Sear, RP and McDonald, PJ (2006) Observations of coarsening of air voids in a polymer-highly-soluble crystalline matrix during dissolution PHYSICAL REVIEW E, 74 (1). ? - ?. ISSN 1539-3755

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Abstract

A combination of magnetic resonance imaging and x-ray microcomputed tomography has been used to visualize the development of the internal micro-structure within compressed tablets made from a combination of insoluble particles (Eudragit, a polymer) and soluble particles (diltiazem hydrochloride, a drug), during dissolution in water. Air voids in the tablet are seen to coarsen. The size distribution of the air voids is well fitted by a log-normal distribution with a mean size that grows linearly with time. There is evidence for both diffusion of voids and sudden collapse of individual voids, presumably as they coalesce. The behavior of the voids is studied and compared with models of coarsening; the implications for tablet dissolution are considered.

Item Type: Article
Uncontrolled Keywords: Science & Technology, Physical Sciences, Physics, Fluids & Plasmas, Physics, Mathematical, Physics, DRUG-RELEASE, SUSTAINED-RELEASE, EUDRAGIT-RL, DIFFUSION, TABLETS, WATER, RS, INDOMETHACIN, DISPERSIONS, MICROSCOPY
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Divisions: Faculty of Engineering and Physical Sciences > Physics
Depositing User: Mr Adam Field
Date Deposited: 27 May 2010 14:05
Last Modified: 23 Sep 2013 18:25
URI: http://epubs.surrey.ac.uk/id/eprint/91

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