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Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population

Puett, Robin C., Poulsen, Aslak Harbo, Taj, Tahir, Ketzel, Matthias, Geels, Camilla, Brandt, Jørgen, Christensen, Jesper H., Sørensen, Mette, Roswall, Nina, Hvidtfeldt, Ulla and Raaschou-Nielsen, Ole (2020) Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population British Journal of Cancer.

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Abstract

Background

Few population-based epidemiological studies of adults have examined the relationship between air pollution and leukaemias.

Methods

Using Danish National Cancer Registry data and Danish DEHM-UBM-AirGIS system-modelled air pollution exposures, we examined whether particulate matter (PM2.5), black carbon (BC), nitrogen dioxide (NO2) and ozone (O3) averaged over 1, 5 or 10 years were associated with adult leukaemia in general or by subtype. In all, 14,986 adult cases diagnosed 1989–2014 and 51,624 age, sex and time-matched controls were included. Separate conditional logistic regression models, adjusted for socio-demographic factors, assessed exposure to each pollutant with leukaemias.

Results

Fully adjusted models showed a higher risk of leukaemia with higher 1-, 5- and 10-year-average exposures to PM2.5 prior to diagnosis (e.g. OR per 10 µg/m3 for 10-year average: 1.17, 95% CI: 1.03, 1.32), and a positive relationship with 1-year average BC. Results were driven by participants 70 years and older (OR per 10 µg/m3 for 10-year average: 1.35, 95% CI: 1.15–1.58). Null findings for younger participants. Higher 1-year average PM2.5 exposures were associated with higher risks for acute myeloid and chronic lymphoblastic leukaemia.

Conclusion

Among older adults, higher risk for leukaemia was associated with higher residential PM2.5 concentrations averaged over 1, 5 and 10 years prior to diagnosis.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Civil and Environmental Engineering
Authors : Puett, Robin C., Poulsen, Aslak Harbo, Taj, Tahir, Ketzel, Matthias, Geels, Camilla, Brandt, Jørgen, Christensen, Jesper H., Sørensen, Mette, Roswall, Nina, Hvidtfeldt, Ulla and Raaschou-Nielsen, Ole
Date : 17 September 2020
DOI : 10.1038/s41416-020-01058-2
Copyright Disclaimer : Copyright © 2020, Springer Nature. Note: This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).
Uncontrolled Keywords : Leukaemia; Risk factors
Depositing User : Clive Harris
Date Deposited : 07 Oct 2020 15:58
Last Modified : 07 Oct 2020 15:58
URI: http://epubs.surrey.ac.uk/id/eprint/858708

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