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In vivo imaging of the depth-resolved optic axis of birefringence in human skin

Li, Qingyun, Sampson, David D. and Villiger, Martin (2020) In vivo imaging of the depth-resolved optic axis of birefringence in human skin Optics Letters, 45 (17). pp. 4919-4922.

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Abstract

Recent progress has enabled the reconstruction of the local (i.e., depth-resolved) optic axis (OAx) of biological tissue from measurements made with polarization-sensitive optical coherence tomography (PS-OCT). Here we demonstrate local OAx imaging in healthy human skin in vivo. The images reveal dense, weaving patterns that are imperceptible in OCT intensity tomograms or conventional PS-OCT metrics and that suggest a mesh-like tissue organization, consistent with the morphology of dermal collagen. Using co-registered polarization-sensitive optical coherence microscopy, we furthermore investigated the impact of spatial resolution on the recovered OAx patterns and confirmed their consistency. OAx orientation as a contrast mechanism merits further exploration for applications in dermatology.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences
Surrey research (other units)
Authors :
NameEmailORCID
Li, Qingyun
Sampson, David D.d.sampson@surrey.ac.uk
Villiger, Martin
Date : 31 August 2020
DOI : 10.1364/OL.400855
Copyright Disclaimer : © 2020 Optical Society of America. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modifications of the content of this paper are prohibited.
Depositing User : Clive Harris
Date Deposited : 02 Sep 2020 15:31
Last Modified : 02 Sep 2020 15:31
URI: http://epubs.surrey.ac.uk/id/eprint/858528

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