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Novel alkaloids and a ceramide from Brunsvigia natalensis (Amaryllidaceae) and their anti-neoplastic activity

Moodley, N., Crouch, N.R., Bastida, J. and Mulholland, D.A. (2020) Novel alkaloids and a ceramide from Brunsvigia natalensis (Amaryllidaceae) and their anti-neoplastic activity South African Journal of Botany.

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Novel alkaloids and a ceramide from Brunsvigia natalensis - AAM.DOC - Accepted version Manuscript
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Abstract

Two new 5,10b-ethanophenanthridine bridge alkaloids, 3-O-methyl–epi–vittatine, 1, and crouchinine, 2, (2R)-7-hydroxyflavan, 3, and a novel ceramide, brunsceramide, were isolated from the bulbs of Brunsvigia natalensis. (2R)-7-Hydroxyflavan showed total growth inhibition in the 55–60 ppm range against the melanoma (UACC62), breast (MCF7) and renal (TK10) cancer cell lines. 3-O-Methyl–epi–vittatine, 1, and bruns-ceramide, 4, were inactive against the cell lines tested.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Moodley, N.
Crouch, N.R.
Bastida, J.
Mulholland, D.A.D.Mulholland@surrey.ac.uk
Date : 2020
DOI : 10.1016/j.sajb.2020.07.029
Copyright Disclaimer : © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Amaryllidaceae; Anti-proliferative activity; Brunsceramide; Brunsvigia natalensis; Crouchinine; (2R)-7-Hydroxyflavan; 3-O-Methyl-epi-vittatine
Depositing User : Clive Harris
Date Deposited : 02 Sep 2020 14:35
Last Modified : 02 Sep 2020 14:35
URI: http://epubs.surrey.ac.uk/id/eprint/858527

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