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Diterpenoids from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert

Langat, Moses K., Ndunda, Beth M., Salter, Caitlin, Odusina, Babatope O., Isyaka, Sani M., Mas-Claret, Eduard, Onocha, Patricia A., Midiwo, Jacob O., Nuzillard, Jean-Marc and Mulholland, Dulcie A. (2020) Diterpenoids from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert Phytochemistry Letters, 39. pp. 1-7.

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Abstract

Five previously undescribed compounds, megalocarpoidolide I (1), megalocarpoidolide J (3), 12-epi-crotonzambefuran A (4), megalocarpoidolide K (5), 1-trans-p-hydroxycoumaroyl–geranylgerani-1-ol (6) were isolated from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert. The known ent-trachyloban-18-ol, megalocarpoidolide B, megalocarpoidolide C (2), megalocarpoidolide H, crotocorylifuran, 7,8-dehydrocrotocorylifuran, 1,2-dehydrocrotocorylifuran-2-one, acetyl aleuritolic acid, lupeol, N-trans-p-coumaroyl-3′,4′-dihydroxyphenylethylamine, dodecyl trans-ferulate and lignoceryl trans-ferulate were also isolated. The structures of the compounds were determined using NMR, IR spectroscopy and HRMS. The structure of compound 1 was determined using Logic for Structural Determination (LSD). Compounds 1, 2 and 3 that were selected for screening based on their ability to add diversity to the NCI small molecule compound collection, were evaluated against the NCI60 panel of human tumour cell lines at 10μM level but found to be inactive.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Langat, Moses K.ml0019@surrey.ac.uk
Ndunda, Beth M.
Salter, Caitlin
Odusina, Babatope O.
Isyaka, Sani M.
Mas-Claret, Eduarde.masclaret@surrey.ac.uk
Onocha, Patricia A.
Midiwo, Jacob O.
Nuzillard, Jean-Marc
Mulholland, Dulcie A.D.Mulholland@surrey.ac.uk
Date : October 2020
DOI : 10.1016/j.phytol.2020.07.003
Copyright Disclaimer : © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Croton megalocarpoides Friis & M. G. Gilbert; Euphorbiaceae; Megalocarpoidolide I; Megalocarpoidolide J; Megalocarpoidolide K; 12-epi-crotonzambefuran A; 1-trans-p-hydroxycoumaroyl–geranylgerani-1-ol; Logic for Structure Determination;
Depositing User : Clive Harris
Date Deposited : 02 Sep 2020 09:27
Last Modified : 02 Sep 2020 09:27
URI: http://epubs.surrey.ac.uk/id/eprint/858525

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