Cytotoxic diterpenoids from the leaves and stem bark of Croton haumanianus (Euphorbiaceae)
Isyaka, Sani M., Mas-Claret, Eduard, Langat, Moses K., Hodges, Thomas, Selway, Bethany, Mbala, Blaise M., Mvingu, Bienvenu K. and Mulholland, Dulcie (2020) Cytotoxic diterpenoids from the leaves and stem bark of Croton haumanianus (Euphorbiaceae) Phytochemistry, 178, 112455.
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Cytotoxic diterpenoids - AAM.docx - Accepted version Manuscript Restricted to Repository staff only until 21 July 2021. Download (4MB) |
Abstract
The leaf extract of Croton haumanianus J. Léonard (Euphorbiaceae) yielded twenty-six compounds, including eight previously reported ent-kauranes and an ent-labdane and eight undescribed ent-kauranes, ent-16R-kauran-17-al, ent-3β-hydroxy-16R-kauran-17-al, ent-16S,17-epoxykauran-19-ol, ent-16S,17-epoxykauran-3β-ol, ent-17-palmityloxykaurane-3β,16β-diol, ent-17-palmityloxykauran-16β-ol, ent-3α,18-cyclokaurane-16β,17-diol and 19-nor-16α,17-dihydroxy-ent-kaur-4(18)-ene and three undescribed ent-clerodanes, dimethyl ent-15,16-epoxy-6β-hydroxy-1,3,13(16),14-clerodatetraen-20,12S-olide-18,19-dioate (saniolide A), dimethyl ent-15,16-epoxy-6β-hydroxy-1,3,13(16),14-clerodatetraen-20,12R-olide-18,19-dioate (12-epi-saniolide A), methyl ent-15,16-epoxy-1,3,13(16),14-clerodatetraen-18,6R:20,12S-diolide-19-oate (saniolide B) . The stem bark extract yielded the ent-clerodane crotocorylifuran, and five undescribed ent-isopimaranesent-isopimara-8(14),15-dien-18-al, ent-18-hydroxyisopimara-8(14),15-dien-7-one, ent-isopimara-7,15-dien-18-oic acid, ent-isopimara-7,15-dien-18-ol and ent-isopimara-8,15-dien-7-oxo-18-oic acid. Three compounds, ent-kaurane-3β,16β,17-triol, ent-17-palmityloxykaurane-3β,16β-diol and ent-17-palmityloxykauran-16β-ol, showed selective activity against three of the NCI 60 cancer cell lines, the colon (HCT-116), the melanoma (M14) and the renal (786-0) cancer cell lines at a concentration of 10-5 M.
Item Type: | Article | |||||||||||||||||||||||||||
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Divisions : | Faculty of Engineering and Physical Sciences > Chemistry | |||||||||||||||||||||||||||
Authors : |
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Date : | October 2020 | |||||||||||||||||||||||||||
DOI : | 10.1016/j.phytochem.2020.112455 | |||||||||||||||||||||||||||
Grant Title : | International Exchanges award | |||||||||||||||||||||||||||
Copyright Disclaimer : | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||||||||||
Uncontrolled Keywords : | Croton haumanianus; Euphorbiaceae; Ent-kaurane; Ent-clerodane; Ent-isopimarane; Anti-proliferative activity | |||||||||||||||||||||||||||
Depositing User : | Clive Harris | |||||||||||||||||||||||||||
Date Deposited : | 01 Sep 2020 15:33 | |||||||||||||||||||||||||||
Last Modified : | 01 Sep 2020 15:34 | |||||||||||||||||||||||||||
URI: | http://epubs.surrey.ac.uk/id/eprint/858523 |
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