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Melanin Production Inhibitors from the West African Cassipourea congoensis

Takou, Dieudonné M., Waffo, Alain F. Kamdem, Langat, Moses K., Wansi, Jean D., Mulcahy-Ryan, Lauren E., Schwikkard, Sianne L., Opara, Elizabeth I., Mas-Claret, Eduard and Mulholland, Dulcie (2019) Melanin Production Inhibitors from the West African Cassipourea congoensis Planta Medica International Open, 6 (02). e50-e56.

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Abstract

Cassipourea congoensis (syn. Cassipourea malosana) is used in African countries as a skin-lightening agent. Two previously unreported cycloartane triterpenoids, 26-hydroxy-3-keto-24-methy lenecycloartan-30-oic acid 1 and 24-methylene-cycloartan-3β,26,30-triol 2 along with the known mahuannin B 3, 7-methoxymahuannin B 4, 7-methoxygeranin A 5, methyl-3-(4-hydroxy-3-methoxyphenyl)-2E-propenoate, glycerol-1-alkanoate, (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal 6, (-)-syringaresinol 7, and stigmast-5-en-3-O-β-D-glucoside, were isolated from the roots of C. congoensis. The crude extract and compounds 1 and 5 were found to inhibit the production of melanin at 10 μM with low cytotoxicity validating the ethno-medicinal use of this plant

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Takou, Dieudonné M.
Waffo, Alain F. Kamdem
Langat, Moses K.
Wansi, Jean D.
Mulcahy-Ryan, Lauren E.
Schwikkard, Sianne L.
Opara, Elizabeth I.
Mas-Claret, Eduarde.masclaret@surrey.ac.uk
Mulholland, DulcieD.Mulholland@surrey.ac.uk
Date : 1 October 2019
Funders : Royal Society
DOI : 10.1055/a-1006-2880
Copyright Disclaimer : © Georg Thieme Verlag KG Stuttgart · New York
Additional Information : Embargo OK Metadata OK No Further Action
Depositing User : James Marshall
Date Deposited : 26 Aug 2020 11:17
Last Modified : 03 Sep 2020 18:52
URI: http://epubs.surrey.ac.uk/id/eprint/858503

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