University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Melanin Production Inhibitors from the West African Cassipourea congoensis

Takou, Dieudonné M., Waffo, Alain F. Kamdem, Langat, Moses K., Wansi, Jean D., Mulcahy-Ryan, Lauren E., Schwikkard, Sianne L., Opara, Elizabeth I., Mas-Claret, Eduard and Mulholland, Dulcie (2019) Melanin Production Inhibitors from the West African Cassipourea congoensis Planta Medica International Open, 6 (02). e50-e56.

Cassiporea congoensis[293396].pdf - Version of Record
Available under License Creative Commons Attribution.

Download (3MB) | Preview


Cassipourea congoensis (syn. Cassipourea malosana) is used in African countries as a skin-lightening agent. Two previously unreported cycloartane triterpenoids, 26-hydroxy-3-keto-24-methy lenecycloartan-30-oic acid 1 and 24-methylene-cycloartan-3β,26,30-triol 2 along with the known mahuannin B 3, 7-methoxymahuannin B 4, 7-methoxygeranin A 5, methyl-3-(4-hydroxy-3-methoxyphenyl)-2E-propenoate, glycerol-1-alkanoate, (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal 6, (-)-syringaresinol 7, and stigmast-5-en-3-O-β-D-glucoside, were isolated from the roots of C. congoensis. The crude extract and compounds 1 and 5 were found to inhibit the production of melanin at 10 μM with low cytotoxicity validating the ethno-medicinal use of this plant

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
Takou, Dieudonné M.
Waffo, Alain F. Kamdem
Langat, Moses K.
Wansi, Jean D.
Mulcahy-Ryan, Lauren E.
Schwikkard, Sianne L.
Opara, Elizabeth I.
Date : 1 October 2019
Funders : Royal Society
DOI : 10.1055/a-1006-2880
Copyright Disclaimer : © Georg Thieme Verlag KG Stuttgart · New York
Additional Information : Embargo OK Metadata OK No Further Action
Depositing User : James Marshall
Date Deposited : 26 Aug 2020 11:17
Last Modified : 03 Sep 2020 18:52

Actions (login required)

View Item View Item


Downloads per month over past year

Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800