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Development and Implementation of an End-To-End Test for Absolute Dose Verification of Small Animal Preclinical Irradiation Research Platforms

Silvestre Patallo, Ileana, Subiel, Anna, Westhorpe, Adam, Gouldstone, Clare, Tulk, Amanda, Sharma, Ricky A. and Schettino, Giuseppe (2020) Development and Implementation of an End-To-End Test for Absolute Dose Verification of Small Animal Preclinical Irradiation Research Platforms International Journal of Radiation Oncology*Biology*Physics, 107 (3). pp. 587-596.

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Abstract

Purpose Lack of standardization and inaccurate dosimetry assessment in preclinical research is hampering translational opportunities for new radiation therapy interventions. The aim of this work was to develop and implement an end-to-end dosimetry test for small animal radiation research platforms to monitor and help improve accuracy of dose delivery and standardization across institutions. Methods and Materials The test is based on a bespoke zoomorphic heterogeneous mouse and WT1 Petri dish phantoms with alanine as a reference detector. Alanine measurements within the mouse phantom were validated with Monte Carlo simulations at 0.5 mm Cu x-ray reference beam. Energy dependence of alanine in medium x-ray beam qualities was taken into consideration. For the end-to-end test, treatment plans considering tissue heterogeneities were created in Muriplan treatment planning systems (TPS) and delivered to the phantoms at 5 institutions using Xstrahl's small animal irradiation platforms. Mean calculated dose to the pellets were compared with alanine measured dose. Results Monte Carlo simulations and in phantom alanine measurements in NPL's reference beam were in excellent agreement, validating the experimental approach. At 1 institute, initial measurements showed a larger than 12% difference between calculated and measured dose caused by incorrect input data. The physics data used by the calculation engine were corrected, and the TPS was recommissioned. Subsequent end-to-end test measurements showed differences <5%. With an anterior field, 4 of the participating institutes delivered dose within 5% to both phantoms. Conclusions An end-to-end dosimetry test was developed and implemented for dose evaluation in preclinical irradiation with small animal irradiation research platforms. The test was capable of detecting treatment planning commissioning errors and highlighted critical elements in dose calculation. Absolute dosimetry with alanine in relevant preclinical irradiation conditions showed reasonable levels of accuracy compared with TPS calculations. This work provides an independent and traceable dosimetric validation in preclinical research involving small animal irradiation.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Physics
Authors :
NameEmailORCID
Silvestre Patallo, Ileana
Subiel, Anna
Westhorpe, Adam
Gouldstone, Clare
Tulk, Amanda
Sharma, Ricky A.
Schettino, Giuseppegiuseppe.schettino@surrey.ac.uk
Date : 10 March 2020
DOI : 10.1016/j.ijrobp.2020.03.001
Copyright Disclaimer : © 2020 Published by Elsevier Inc.
Additional Information : Embargo OK Metadata OK No Further Action
Depositing User : James Marshall
Date Deposited : 25 Aug 2020 16:08
Last Modified : 25 Aug 2020 16:08
URI: http://epubs.surrey.ac.uk/id/eprint/858500

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