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Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography

Gong, Peijun, Heiss, Christian, Sampson, Danuta, Wang, Qiang, Yuan, Zhihong and Sampson, David (2020) Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography Journal of Biomedical Optics, 25 (9), 095004.

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Abstract

Significance: Pulsatility is a vital characteristic of the cardiovascular system. Characterization of the pulsatility pattern locally in the peripheral microvasculature is currently not readily available and would provide an additional source of information which may prove important in understanding the pathophysiology of arterial stiffening, vascular ageing, and their linkage with cardiovascular disease development.

Aim: We aim to confirm the suitability of speckle decorrelation optical coherence tomography angiography (OCTA) under various non-contact/contact scanning protocols for the visualization of pulsatility patterns in vessel-free tissue and in the microvasculature of peripheral human skin.

Results: Results from 5 healthy subjects show distinct pulsatile patterns both in vessel-free tissue with either non-contact or contact imaging and in individual microvessels with contact imaging; respectively, likely caused by the pulsatile pressure and pulsatile blood flow. The pulse rates show good agreement with those from pulse oximetry, confirming that the pulsatile signatures reflect pulsatile hemodynamics.

Conclusions: This study demonstrates the potential of speckle decorrelation OCTA for measuring localized peripheral cutaneous pulsatility and defines scanning protocols necessary to undertake such measurements. Non-contact imaging should be used for the study of pulsatility in vessel-free tissue and contact imaging with strong mechanical coupling in individual microvessels. Further studies of microcirculation based upon this method and protocols are warranted.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Gong, Peijun
Heiss, Christianc.heiss@surrey.ac.uk
Sampson, Danutadanuta.sampson@surrey.ac.uk
Wang, Qiang
Yuan, Zhihong
Sampson, Davidd.sampson@surrey.ac.uk
Date : 15 September 2020
Funders : University of Surrey, Higher Education Innovation Funding Industrial Strategy
DOI : 10.1117/1.JBO.25.9.095004
Copyright Disclaimer : © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Depositing User : James Marshall
Date Deposited : 20 Aug 2020 13:07
Last Modified : 07 Oct 2020 13:23
URI: http://epubs.surrey.ac.uk/id/eprint/858453

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