Monocyte activation in systemic CoVid-19 infection: assay and rationale

Martinez, Fernando O., Combes, Theo, Orsenigo, Federica and Gordon, Siamon (2020) Monocyte activation in systemic CoVid-19 infection: assay and rationale EBioMedicine.

Text MONOCYTE ACTIVATION IN SYSTEMIC COVID-19 INFECTION - AAM.pdf - Accepted version Manuscript Restricted to Repository staff only Download (479kB)

Abstract

Mononuclear phagocytes are a widely distributed family of cells contributing to innate and adaptive immunity. Circulating monocytes and tissue macrophages participate in all stages of SARS COVID-19. They contribute to comorbidities predisposing to clinical infection, virus resistance and dissemination, and to host factors that determine disease severity, recovery and sequelae. Assays are available to detect viral infection and antibody responses, but no adequate tests have been developed to measure the activation level of monocytes and tissue macrophages, and the risk of progression to a fatal hyperinflammatory syndrome. Blood monocytes provide a window on the systemic immune response, from production to tissue recruitment, reflecting the impact of infection on the host. Ready availability of blood makes it possible to monitor severity and the risk of potentially lethal complications, by developing tests to assess the status of monocyte activation and its potential for further inflammatory dysregulation after recruitment to tissues and during recovery.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :	Name Email ORCID Martinez, Fernando O. f.martinezestrada@surrey.ac.uk Combes, Theo t.combes@surrey.ac.uk Orsenigo, Federica f.orsenigo@surrey.ac.uk Gordon, Siamon
Date :	2020
Funders :	University of Surrey
Grant Title :	HEIF COVID-19 impact grant
Copyright Disclaimer :	© 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/)
Uncontrolled Keywords :	CSF1R; CSF2R; CSF3R; Monocyte; Activation; Macrophages; COVID-19
Related URLs :	Publisher
Depositing User :	Clive Harris
Date Deposited :	17 Aug 2020 11:34
Last Modified :	17 Aug 2020 11:34
URI:	http://epubs.surrey.ac.uk/id/eprint/858418

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