University of Surrey

Test tubes in the lab Research in the ATI Dance Research

MONOCYTE ACTIVATION IN SYSTEMIC COVID-19 INFECTION: ASSAY AND RATIONALE

Martinez Estrada, Fernando Oneissi, Combes, Theo, Orsenigo, Federica and Gordon, Siamon (2020) MONOCYTE ACTIVATION IN SYSTEMIC COVID-19 INFECTION: ASSAY AND RATIONALE EBioMedicine.

[img]
Preview
Text
EBIOM-D-20-01864 proof 11.08.2020.pdf - Proof
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB) | Preview

Abstract

Mononuclear phagocytes are a widely distributed family of cells contributing to innate and adaptive immunity. Circulating monocytes and tissue macrophages participate in all stages of SARS COVID-19. They contribute to comorbidities predisposing to clinical infection, virus resistance and dissemination, and to host factors that determine disease severity, recovery and sequelae. Assays are available to detect viral infection and antibody responses, but no adequate tests have been developed to measure the activation level of monocytes and tissue macrophages, and the risk of progression to a fatal hyperinflammatory syndrome. Blood monocytes provide a window on the systemic immune response, from production to tissue recruitment, reflecting the impact of infection on the host. Ready availability of blood makes it possible to monitor severity and the risk of potentially lethal complications, by developing tests to assess the status of monocyte activation and its potential for further inflammatory dysregulation after recruitment to tissues and during recovery.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Martinez Estrada, Fernando Oneissif.martinezestrada@surrey.ac.uk
Combes, Theot.combes@surrey.ac.uk
Orsenigo, Federicaf.orsenigo@surrey.ac.uk
Gordon, Siamon
Date : 4 August 2020
Funders : University of Surrey
DOI : 10.1016/j.ebiom.2020.102964
Grant Title : HEIF COVID-19 impact grant
Copyright Disclaimer : © 2020 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Additional Information : Embargo OK Metadata Pending
Depositing User : James Marshall
Date Deposited : 14 Aug 2020 14:29
Last Modified : 14 Aug 2020 14:29
URI: http://epubs.surrey.ac.uk/id/eprint/858413

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800