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Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark

Poulsen, Aslak Harbo, Hvidtfeldt, Ulla Arthur, Sørensen, Mette, Puett, Robin, Ketzel, Matthias, Brandt, Jørgen, Geels, Camilla, Christensen, Jesper H. and Raaschou-Nielsen, Ole (2020) Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark Environmental Health, 19 (81).

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Background: Inconclusive evidence has suggested a possible link between air pollution and central nervous system (CNS) tumors. We investigated a range of air pollutants in relation to types of CNS tumors. Methods: We identified all (n = 21,057) intracranial tumors in brain, meninges and cranial nerves diagnosed in Denmark between 1989 and 2014 and matched controls on age, sex and year of birth. We established personal 10- year mean residential outdoor exposure to particulate matter < 2.5 μm (PM2.5), nitrous oxides (NOX), primary emitted black carbon (BC) and ozone. We used conditional logistic regression to calculate odds ratios (OR) linearly (per interquartile range (IQR)) and categorically. We accounted for personal income, employment, marital status, use of medication as well as socio-demographic conditions at area level. Results: Malignant tumors of the intracranial CNS was associated with BC (OR: 1.034, 95%CI: 1.005–1.065 per IQR. For NOx the OR per IQR was 1.026 (95%CI: 0.998–1.056). For malignant non-glioma tumors of the brain we found associations with PM2.5 (OR: 1.267, 95%CI: 1.053–1.524 per IQR), BC (OR: 1.049, 95%CI: 0.996–1.106) and NOx (OR: 1.051, 95% CI: 0.996–1.110). Conclusion: Our results suggest that air pollution is associated with malignant intracranial CNS tumors and malignant non-glioma of the brain. However, additional studies are needed.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Civil and Environmental Engineering
Authors :
Poulsen, Aslak Harbo
Hvidtfeldt, Ulla Arthur
Sørensen, Mette
Puett, Robin
Brandt, Jørgen
Geels, Camilla
Christensen, Jesper H.
Raaschou-Nielsen, Ole
Date : 8 July 2020
Funders : NordForsk - Nordic Programme on Health and Welfare
DOI : 10.1186/s12940-020-00631-9
Copyright Disclaimer : © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Projects : #75007, NordicWelfAir - Understanding the link between Air pollution and Distribution of related Health Impacts and Welfare in the Nordic countries).
Uncontrolled Keywords : Epidemiology, Air pollution, Register study, CNS-tumors
Additional Information : Embargo OK Metadata OK No Further Action
Depositing User : James Marshall
Date Deposited : 13 Aug 2020 15:56
Last Modified : 13 Aug 2020 15:56

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