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The effects of screw-to-roll speed ratio on ribbon porosity during roll compaction

Olaleye, Busayo, Wu, Chuan-Yu and Liu, Lian (2020) The effects of screw-to-roll speed ratio on ribbon porosity during roll compaction International Journal of Pharmaceutics.

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Abstract

Dry granulation through roll compaction is a technology commonly used in the pharmaceutical industry for producing roll compacted ribbons. The significance of the feed screw speed and roll speed during ribbon production was highlighted in recent publications. However, previous studies focused primarily on the individual effects of either the feed screw speed or roll speed on ribbon porosity, and the synergetic effect of these parameters was rarely examined. The aim of this study therefore was to investigate the effects of the screw-to-roll speed ratio on the porosity of roll compacted ribbons, produced at different roll compaction conditions using the microcrystalline cellulose MCC, Avicel PH-102 feed material. It was observed that ribbon porosity decreased linearly with increasing screw-to-roll speed ratio. Furthermore, an increase in the speed ratio led to an increase in the roll gap and mass throughput while a decrease in the screw constant was observed. Thus, this study demonstrates that the screw-to-roll speed ratio can be treated as one of the critical process parameters for controlling ribbon porosity and can also be used to determine the optimum operating regimes during roll compaction.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
NameEmailORCID
Olaleye, Busayoo.onasile@surrey.ac.uk
Wu, Chuan-Yu
Liu, Lianl.x.liu@surrey.ac.uk
Date : 11 August 2020
Uncontrolled Keywords : Dry granulation, roll compaction, critical process parameters, speed ratio, ribbon porosity
Additional Information : Embargo OK Metadata Pending
Depositing User : James Marshall
Date Deposited : 13 Aug 2020 09:50
Last Modified : 13 Aug 2020 09:50
URI: http://epubs.surrey.ac.uk/id/eprint/858402

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