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Primary Care Prostate Cancer Case Ascertainment

Lemanska, Agnieszka, Faithfull, Sara, Liyanage, Harshana, Otter, Sophie, Romanchikova, Marina, Sherlock, Julian, Smith, Nadia, Thomas, Spencer and Lusignan, Simon de Primary Care Prostate Cancer Case Ascertainment In: Studies in health technology and informatics. IOS Press, pp. 1369-1370.

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Although routine healthcare data are not collected for research, they are increasingly used in epidemiology and are key real-world evidence for improving healthcare. This study presents a method to identify prostate cancer cases from a large English primary care database. 19,619 (1.3%) men had a code for prostate cancer diagnosis. Codes for medium and high Gleason grading enabled identification of additional 94 (0.5%) cases. Many studies do not report codes used to identify patients, and if published, the lists of codes differ from study to study. This can lead to poor research reproducibility and hinder validation. This work demonstrates that carefully developed comprehensive lists of clinical codes can be used to identify prostate cancer; and that approaches that do not solely rely on clinical codes such as ontologies or data linkage should also be considered.

Item Type: Book Section
Divisions : Faculty of Health and Medical Sciences > School of Health Sciences
Authors :
Otter, Sophie
Romanchikova, Marina
Sherlock, Julian
Lusignan, Simon de
DOI : 10.3233/SHTI200446
OA Location :
Copyright Disclaimer : © 2020 European Federation for Medical Informatics (EFMI) and IOS Press. This article is published online with Open Access by IOS Press and distributed under the terms of the Creative Commons Attribution Non-Commercial License 4.0 (CC BY-NC 4.0).
Uncontrolled Keywords : Prostate cancer, primary care, case identification, real-world evidence
Additional Information : Embargo OK Metadata OK No Further Action
Depositing User : James Marshall
Date Deposited : 13 Aug 2020 08:38
Last Modified : 13 Aug 2020 08:38

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