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Neurobehavioral Disorders: The Corticolimbic System in Health and Disease

Rusbridge, Clare (2020) Neurobehavioral Disorders: The Corticolimbic System in Health and Disease Veterinary Clinics of North America: Small Animal Practice, 50 (5). pp. 1157-1181.

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Abstract

The corticolimbic system (Fig. 1) integrates emotion with cognition and produces a behavioral output that must be flexible based on the environmental circumstances.1 The corticolimbic system circuitry of the prefrontal cortex, amygdala, and hippocampus is connected to the hypopituitary-pituitary axis, and environmental circumstances such as stress and anxiety input decision making, emotion regulation, and memory.1 The corticolimbic system is also the modulator for acute pain, a mediator for chronic pain, and critical for the chronification of pain.2 There is a high comorbidity of negative affective disorders with chronic pain and vice versa, hypothesized because of similar changes in neuroplasticity and overlapping neurobiological mechanisms.3 This article discusses 3 feline disorders that affect or are affected by the corticolimbic systems: the maladaptive pain disorder feline orofacial pain syndrome (FOPS) in which disease expression is influenced by environmental stress; feline hyperesthesia syndrome (FHS) in which there is still debate as to whether this is a primary neurobehavioral disorder or a behavioral response to a negative affective state; and limbic encephalitis, an autoimmune encephalitis that results in neurobehavioral signs and seizures. There is a focus on diagnosis and management, which is challenging in all 3 diseases.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Rusbridge, Clarec.rusbridge@surrey.ac.uk
Date : 14 July 2020
DOI : 10.1016/j.cvsm.2020.06.009
Copyright Disclaimer : Crown Copyright © 2020 Published by Elsevier Inc. All rights reserved.
Uncontrolled Keywords : Feline orofacial pain; Feline hyperaesthesia; Limbic encephalitis; Mutilation; Neuropathic pain; Neuropathic itch; Trigeminal neuralgia; Temporal lobe epilepsy;
Additional Information : Embargo OK Metadata OK Require accepted manuscript version from author.
Depositing User : James Marshall
Date Deposited : 10 Aug 2020 09:14
Last Modified : 10 Aug 2020 09:14
URI: http://epubs.surrey.ac.uk/id/eprint/858378

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