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Selenium status in a Northern Irish pregnant cohort with iodine deficiency

Mullan, K.R, McMullan, P., Hunter, A., McCance, D.R, Smyth, P., Bath, S.C, Rayman, M. and Woodside, J.V (2020) Selenium status in a Northern Irish pregnant cohort with iodine deficiency European Journal of Clinical Nutrition.

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Abstract

Selenium and iodine are trace elements that are maximally concentrated in the thyroid. Iodine is a substrate for thyroid hormone synthesis, while the selenoproteins protect the thyroid from the oxidative stress incurred. We measured plasma selenium concentration in 241 pregnant women in 1st trimester, previously reported to have iodine deficiency. Mean age was 30.3 years (SD 5.4), BMI 26.2 kg/m2 (SD 4.9) and 53% reported taking supplements. Median urinary-iodine concentration was 73 μg/L (IQR 37-122) (WHO recommendation, ≥150 μg/L). Mean plasma-selenium concentration was 75 μg/L (SD 7.7) which is below the 80-125 μg/L reported to be optimal. Four-day food diaries revealed a selenium intake of 43μg/day (SD 15.9), also below the 55-70 μg/day reported to be optimal. This is the first report of selenium status in pregnancy on the island of Ireland. The possible combined effects of iodine and selenium deficiencies in pregnancy merit further investigation.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Mullan, K.R
McMullan, P.
Hunter, A.
McCance, D.R
Smyth, P.
Bath, S.Csarah.c.bath@surrey.ac.uk
Rayman, M.M.Rayman@surrey.ac.uk
Woodside, J.V
Date : 20 July 2020
Additional Information : 6 Month Embargo for Accepted Version Metadata Pending
Depositing User : James Marshall
Date Deposited : 23 Jul 2020 15:12
Last Modified : 23 Jul 2020 15:12
URI: http://epubs.surrey.ac.uk/id/eprint/858287

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