Alzheimer’s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness
Muto, Vincenzo, Koshmanova, Ekaterina, Ghaemmaghami, Pouya, Jaspar, Mathieu, Meyer, Christelle, Elansary, Mahmoud, Van Egroo, Maxime, Chylinski, Daphne, Berthomier, Christina, Brandewinder, Marie , Mouraux, Charlotte, Schmidt, Christina, Hammad, Gregory, Coppieters, Wouter, Ahariz, Naima, Degueldre, Christian, Luxen, Andre, Salmon, Eric, Phillips, Christophe, Archer, Simon N., Yengo, Loic, Byrne, Enda, Collette, Fabienne, Georges, Michel, Dijk, Derk-Jan, Maquet, Pierre, Visscher, Peter M. and Vandewalle, Gilles (2020) Alzheimer’s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness Sleep.
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Muto_Sleep_preprint_medrxiv-1.pdf - Accepted version Manuscript Restricted to Repository staff only until 9 July 2021. Download (1MB) |
Abstract
Study Objectives. Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer’s disease. Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young adults, decades before typical AD symptom onset. Methods. We computed whole-genome Polygenic Risk Scores (PRS) for AD and extensively phenotyped sleep under different sleep conditions, including baseline sleep, recovery sleep following sleep deprivation and extended sleep opportunity, in a carefully selected homogenous sample of healthy 363 young men (22.1 y ± 2.7) devoid of sleep and cognitive disorders. Results. AD PRS was associated with more slow wave energy, i.e. the cumulated power in the 0.5-4 Hz EEG band, a marker of sleep need, during habitual sleep and following sleep loss, and potentially with large slow wave sleep rebound following sleep deprivation. Furthermore, higher AD PRS was correlated with higher habitual daytime sleepiness. Conclusions. These results imply that sleep features may be associated with AD liability in young adults, when current AD biomarkers are typically negative, and the notion that quantifying sleep alterations may be useful in assessing the risk for developing AD.
Item Type: | Article | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Divisions : | Faculty of Health and Medical Sciences > School of Biosciences and Medicine | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Date : | 8 July 2020 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Funders : | Fonds de la Recherche Scientifique - FNRS-Belgium., Wallonia-Brussels Federation, FNRS-Belgium, University of Liège, European Regional Development Fund, UK Dementia Research Institute | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Grant Title : | Wallonia-Brussels Federation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Additional Information : | Embargo OK Metadata Pending | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Depositing User : | James Marshall | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Date Deposited : | 15 Jul 2020 09:25 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Last Modified : | 15 Jul 2020 09:25 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
URI: | http://epubs.surrey.ac.uk/id/eprint/858212 |
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