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Common-path diffraction optical tomography for investigation of three-dimensional structures and dynamics of biological cells

Kim, Youngchan, Shim, Hyoeun, Kim, Kyoohyun, Park, HyunJoo, Heo, Ji Han, Yoon, Jonghee, Choi, Chulhee, Jang, Seongsoo and Park, YongKeun (2014) Common-path diffraction optical tomography for investigation of three-dimensional structures and dynamics of biological cells Optics Express, 22 (9). pp. 10398-10407.

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Abstract

We present an optical holographic micro-tomographic technique for imaging both the three-dimensional structures and dynamics of biological cells. Optical light field images of a sample, illuminated by a plane wave with various illumination angles, are measured in a common-path interferometry, and thus both the three-dimensional refractive index tomogram and two-dimensional dynamics of live biological cells are measured with extremely high sensitivity. The applicability of the technique is demonstrated through quantitative and measurements of morphological, chemical, and mechanical parameters at the individual cell level.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Kim, Youngchanyoungchan.kim@surrey.ac.uk
Shim, Hyoeun
Kim, Kyoohyun
Park, HyunJoo
Heo, Ji Han
Yoon, Jonghee
Choi, Chulhee
Jang, Seongsoo
Park, YongKeun
Date : 22 April 2014
DOI : 10.1364/OE.22.010398
Copyright Disclaimer : © 2014 Optical Society of America
Projects : Global Ph.D. Fellowship
Depositing User : James Marshall
Date Deposited : 29 Jun 2020 10:43
Last Modified : 29 Jun 2020 10:43
URI: http://epubs.surrey.ac.uk/id/eprint/858085

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