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Adaptive multiphoton endomicroscopy through a dynamically deformed multicore optical fiber using proximal detection

Warren, Sean C., Kim, Youngchan, Stone, James M., Mitchell, Claire, Knight, Jonathan C., Neil, Mark A. A., Paterson, Carl, French, Paul M. W. and Dunsby, Chris (2016) Adaptive multiphoton endomicroscopy through a dynamically deformed multicore optical fiber using proximal detection Optics Express, 24 (19), 21474.

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This paper demonstrates multiphoton excited fluorescence imaging through a polarisation maintaining multicore fiber (PM-MCF) while the fiber is dynamically deformed using all-proximal detection. Single-shot proximal measurement of the relative optical path lengths of all the cores of the PM-MCF in double pass is achieved using a Mach-Zehnder interferometer read out by a scientific CMOS camera operating at 416 Hz. A non-linear least squares fitting procedure is then employed to determine the deformation-induced lateral shift of the excitation spot at the distal tip of the PM-MCF. An experimental validation of this approach is presented that compares the proximally measured deformation-induced lateral shift in focal spot position to an independent distally measured ground truth. The proximal measurement of deformation-induced shift in focal spot position is applied to correct for deformation-induced shifts in focal spot position during raster-scanning multiphoton excited fluorescence imaging.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Warren, Sean C.
Stone, James M.
Mitchell, Claire
Knight, Jonathan C.
Neil, Mark A. A.
Paterson, Carl
French, Paul M. W.
Dunsby, Chris
Date : 7 September 2016
Funders : EPSRC
DOI : 10.1364/OE.24.021474
Grant Title : Healthcare Technologies Challenges for Engineering research grant
Copyright Disclaimer : Journal © 2016. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
Depositing User : James Marshall
Date Deposited : 29 Jun 2020 08:48
Last Modified : 29 Jun 2020 08:48

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