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Two Mixed Breed Dogs With Sensory Neuropathy Are Homozygous for an Inversion Disrupting FAM134B Previously Identified in Border Collies

Amengual-Batle, Pablo, Rusbridge, Clare, Jose-Lopez, Roberto, Golini, Lorenzo, Shelton, G. Diane, Mellersh, Cathryn S. and Gutierrez-Quintana, Rodrigo (2018) Two Mixed Breed Dogs With Sensory Neuropathy Are Homozygous for an Inversion Disrupting FAM134B Previously Identified in Border Collies Journal of Veterinary Internal Medicine, 32 (6). pp. 2082-2087.

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Abstract

Two unrelated 8-month-old male mixed breed dogs were presented for evaluation of progressive ataxia, knuckling, and lack of pain perception in the distal limbs. Because of the similarity in age of onset, progression, and clinical findings with previously described sensory neuropathy in Border Collies, the affected dogs were screened for an FAM134B mutation and were determined to be homozygous for the mutation. Despite few phenotypic similarities with other breeds, genetic testing for specific diseases should be considered in mixed breed dogs with compatible clinical signs, especially if ancestry is unknown.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Amengual-Batle, Pablo
Rusbridge, Clarec.rusbridge@surrey.ac.uk
Jose-Lopez, Roberto
Golini, Lorenzo
Shelton, G. Diane
Mellersh, Cathryn S.
Gutierrez-Quintana, Rodrigo
Date : 11 October 2018
DOI : 10.1111/jvim.15312
OA Location : https://pubmed.ncbi.nlm.nih.gov/30307654/
Copyright Disclaimer : This is an open access article under the terms of the Creative Commons Attribution-Non Commercial License, which permits use, distribution and reproduction in anymedium, provided the original work is properly cited and is not used for commercial purposes. © 2018 The Authors.Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
Depositing User : James Marshall
Date Deposited : 26 Jun 2020 10:30
Last Modified : 26 Jun 2020 10:30
URI: http://epubs.surrey.ac.uk/id/eprint/858071

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