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Metabolomics markers in Neurology: current knowledge and future perspectives for therapeutic targeting.

Bonomo, Roberta, Cavaletti, Guido and Skene, Debra (2020) Metabolomics markers in Neurology: current knowledge and future perspectives for therapeutic targeting. Expert Review of Neurotherapeutics.

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Abstract

Introduction: Metabolomics is an emerging approach providing new insights into the 7 metabolic changes and underlying mechanisms involved in the pathogenesis of 8 neurological disorders. 9 Areas covered: Here, we present an overview of the current knowledge of metabolic 10 profiling (metabolomics) to provide critical insight on the role of biochemical markers and metabolic alterations in neurological diseases. Expert opinion: Elucidation of characteristic metabolic alterations in neurological disorders is crucial for a better understanding of their pathogenesis, and for identifying potential biomarkers and drug targets. Nevertheless, discrepancies in diagnostic criteria, sample handling protocols, and analytical methods still affect the generalizability of current study results.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Bonomo, Robertar.bonomo@surrey.ac.uk
Cavaletti, Guido
Skene, DebraD.Skene@surrey.ac.uk
Date : 13 June 2020
Funders : Metabolomics Core Facility - University of Surrey
DOI : 10.1080/14737175.2020.1782746
Additional Information : The version on the publisher's website is the author's original (but accepted) version. The final version has yet to be published.
Depositing User : James Marshall
Date Deposited : 25 Jun 2020 08:40
Last Modified : 25 Jun 2020 08:46
URI: http://epubs.surrey.ac.uk/id/eprint/858057

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