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Thioester-functional Polyacrylamides: Rapid Selective Backbone Degradation Triggers Solubility Switch Based on Aqueous LCST/UCST

Bingham, Nathaniel M., Nisa, Qamar-un, Chua, Sophie H.L, Fontugne, Lea, Spick, Matt P. and Roth, Peter J. (2020) Thioester-functional Polyacrylamides: Rapid Selective Backbone Degradation Triggers Solubility Switch Based on Aqueous LCST/UCST ACS Applied Polymer Materials, 2 (8). pp. 3440-3449.

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Radical ring-opening polymerization is a clever strategy to incorporate cleavable linkages into otherwise non-degradable vinyl polymers. But conventional systems suffer from slow copolymerization, harsh non-selective degradation conditions, and limited application potential because the degradation products (often oligomers or polymers themselves) have properties like the intact species. This work presents fast selective degradation accompanied by a drastic change in a key property, aqueous solubility. The thionolactone dibenzo[c,e]oxepane-5-thione was found to copolymerise radically with a range of primary, secondary, and tertiary neutral and zwitterionic acrylamides with rapid incorporation of degradable biphenyl thiocarboxylate repeat units. Intact copolymers displayed temperature-responsive (LCST or UCST-type) aqueous solubility behaviour, tuneable through the molar composition and (exploiting the non-azeotropic copolymerization behaviour) comonomer sequence. Various conditions led to selective and complete degradation of the backbone thioesters through hydrolysis, aminolysis, transthioesterification (including under physiological conditions), and oxidative hydrolysis which drastically increased aqueous solubility. Polymers containing as little as 8 mol-% of thioester repeat units underwent a temperature-independent insoluble–soluble transition upon degradation with cysteine or potassium persulfate. Insoluble polymers were used to block syringe filters which allowed flow of degradant solutions only, relevant relevant to lab-on-a-chip, sensing, and embolic biomedical applications.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
Bingham, Nathaniel
Nisa, Qamar-un
Chua, Sophie H.L
Fontugne, Lea
Spick, Matt P.
Roth, Peter
Date : 14 August 2020
DOI : 10.1021/acsapm.0c00503
Copyright Disclaimer : Copyright © 2020 American Chemical Society
Uncontrolled Keywords : Degradable polymers; Radical ring-opening polymerization; Stimulus-responsive polymers; UCST in water; TARO polymerization; Redox-sensitive polymers; Copolymerization
Depositing User : James Marshall
Date Deposited : 22 Jun 2020 08:28
Last Modified : 19 Aug 2020 09:35

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