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Lipoprotein markers associated with disability from multiple sclerosis

Gafson, A.R, Thorne, Tom, McKechnie, C.I.J, Jimenez, B., Nicholas, R. and Matthews, P.M (2018) Lipoprotein markers associated with disability from multiple sclerosis Scientific Reports, 8, 17026.

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Abstract

Altered lipid metabolism is a feature of chronic inflammatory disorders. Increased plasma lipids and lipoproteins have been associated with multiple sclerosis (MS) disease activity. Our objective was to characterise the specific lipids and associated plasma lipoproteins increased in MS and to test for an association with disability. Plasma samples were collected from 27 RRMS patients (median EDSS, 1.5, range 1–7) and 31 healthy controls. Concentrations of lipids within lipoprotein sub-classes were determined from NMR spectra. Plasma cytokines were measured using the MesoScale Discovery V-PLEX kit. Associations were tested using multivariate linear regression. Differences between the patient and volunteer groups were found for lipids within VLDL and HDL lipoprotein sub-fractions (p < 0.05). Multivariate regression demonstrated a high correlation between lipids within VLDL sub-classes and the Expanded Disability Status Scale (EDSS) (p < 0.05). An optimal model for EDSS included free cholesterol carried by VLDL-2, gender and age (R2= 0.38, p < 0.05). Free cholesterol carried by VLDL-2 was highly correlated with plasma cytokines CCL-17 and IL-7 (R2= 0.78, p < 0.0001). These results highlight relationships between disability, inflammatory responses and systemic lipid metabolism in RRMS. Altered lipid metabolism with systemic inflammation may contribute to immune activation

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Computer Science
Authors :
NameEmailORCID
Gafson, A.R
Thorne, Tomtom.thorne@surrey.ac.uk
McKechnie, C.I.J
Jimenez, B.
Nicholas, R.
Matthews, P.M
Date : 19 November 2018
Funders : Imperial College Healthcare Trust Biomedical Research Centre
DOI : 10.1038/s41598-018-35232-7
Copyright Disclaimer : © The Author(s) 2018. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Depositing User : James Marshall
Date Deposited : 17 Jun 2020 10:18
Last Modified : 17 Jun 2020 10:18
URI: http://epubs.surrey.ac.uk/id/eprint/858007

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