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Long-term exposure to PM2.5 and its constituents and risk of Non-Hodgkin lymphoma in Denmark: A population-based case–control study

Taj, Tahir, Poulsen, Aslak Harbo, Ketzel, Matthias, Geels, Camilla, Brandt, Jorgen, Christensen, Jesper Heile, Puett, Robin, Hvidtfeldt, Ulla Arthur, Sorensen, Mette and Raaschou-Nielsen, Ole (2020) Long-term exposure to PM2.5 and its constituents and risk of Non-Hodgkin lymphoma in Denmark: A population-based case–control study Environmental Research, 188, 109762.

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Abstract

Background Particulate matter (PM) air pollution is a complex mixture and the various PM constituents likely affect health differently. The literature on the relationships among specific PM constituents and the risk of cancer is sparse. In this study, we aimed to evaluate the association of PM2.5 and its constituents with the incidence of non-Hodgkin lymphoma (NHL) and the two main NHL subtypes. Methods We undertook a nationwide register-based case-control study including 20,847 cases registered in the Danish Cancer Registry with NHL between 1989 and 2014. Among the entire Danish population, we selected 41,749 age and sex-matched controls randomly from the Civil Registration System. We assessed modelled outdoor PM concentrations at addresses of cases and controls with a state-of-the-art multi scale air pollution modelling system and used conditional logistic regression to estimate odds ratios (ORs) adjusted for individual and neighborhood level socio-demographic variables. Results The 10-year time-weighted average concentrations of PM2.5, primary carbonaceous particles (BC/OC), secondary inorganic aerosols (SIA), secondary organic aerosols (SOA) and sea salt were 17.4, 2.3, 7.8, 0.3, and 4.1 μg/m3, respectively among controls. The results showed higher risk for NHL in association with exposure to BC/OC (OR = 1.03; 95% CI: 1.00, 1.07, per interquartile range (IQR)) and SOA (OR = 1.54; 95% CI: 1.13, 2.09, per IQR). The results indicated a higher risk for follicular lymphoma in association with several PM components. Including PM2.5 (OR = 1.16; 95% CI: 0.98–1.38), BC/OC (OR = 1.05; 95% CI: 0.97–1.14), SIA (OR = 1.44; 95% CI: 0.80–1.08), SOA (OR = 4.52; 95% CI: 0.86–23.83) per IQR. Conclusion This is the first study on PM constituents and the risk of NHL. The results indicated an association with primary carbonaceous and secondary organic PM. The results need replication in other settings before any firm conclusion can be reached.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Civil and Environmental Engineering
Authors : Taj, Tahir, Poulsen, Aslak Harbo, Ketzel, Matthias, Geels, Camilla, Brandt, Jorgen, Christensen, Jesper Heile, Puett, Robin, Hvidtfeldt, Ulla Arthur, Sorensen, Mette and Raaschou-Nielsen, Ole
Date : 4 June 2020
Funders : Nordic Programme on Health and Welfare
DOI : 10.1016/j.envres.2020.109762
Copyright Disclaimer : © 2020 Elsevier Inc. All rights reserved.
Projects : Nordic Programme on Health and Welfare (#75007)
Uncontrolled Keywords : Particulate matter Non-hodgkin lymphoma Case–control study
Additional Information : Embargo OK Metadta OK
Depositing User : James Marshall
Date Deposited : 16 Jun 2020 10:30
Last Modified : 16 Jun 2020 10:30
URI: http://epubs.surrey.ac.uk/id/eprint/857987

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