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Melatonin in circadian sleep disorders in the blind

Skene, D.J., Lockley, S.W. and Arendt, J. (1999) Melatonin in circadian sleep disorders in the blind NeuroSignals, 8 (1-2). pp. 90-95.

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Assessment of sleep patterns in blind people demonstrates a high prevalence of sleep disorders. Our studies have shown that subjects with no conscious light perception (NPL) have a higher occurrence and more severe sleep disorders than those with some degree of light perception (LP). A detailed study of 49 blind individuals showed that those with NPL are likely to have free-running (FR) circadian rhythms (aMT6s, cortisol) including sleep. Non�24-hour (or FR) sleep-wake disorder, characterised by periods of good and bad sleep is a condition that may benefit from melatonin treatment. Melatonin has been administered to NPL subjects with FR circadian rhythms and compared with placebo (or the no-treatment baseline) sleep parameters improved. The results suggest that prior knowledge of the subject�s type of circadian rhythm, and timing of treatment in relation to the individual�s circadian phase, may improve the efficacy of melatonin. © 1999 S. Karger AG, Basel.

Item Type: Article
Authors :
Skene, D.J.
Arendt, J.
Date : 1999
DOI : 10.1159/000014575
Uncontrolled Keywords : Blindness, Circadian, Circadian rhythms, Cortisol, Free-running, Melatonin, Napping, Sleep, Sleep disorders, hydrocortisone, melatonin, blindness, circadian rhythm, clinical article, drug efficacy, human, hydrocortisone urine level, light, review, sleep disorder, sleep pattern, sleep waking cycle, Blindness, Circadian Rhythm, Humans, Hydrocortisone, Melatonin, Sleep, Sleep Disorders
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 02:04
Last Modified : 17 Jun 2020 02:04

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