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Correlation between urinary cortisol and 6-sulphatoxymelatonin rhythms in field studies of blind subjects

Skene, D.J., Lockley, S.W., James, K. and Arendt, J. (1999) Correlation between urinary cortisol and 6-sulphatoxymelatonin rhythms in field studies of blind subjects Clinical Endocrinology, 50 (6). pp. 715-719.

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OBJECTIVE: Blind individuals have different types of circadian rhythm disorders, in order to study these in the field reliable markers of circadian phase are required. The aim of the present study was to determine the usefulness of urinary cortisol as a marker rhythm in field studies. This was assessed by investigating the relationship between the cortisol rhythms and the previously determined melatonin rhythms from a large sample of blind people with different types of circadian rhythm disorders. DESIGN Field study SUBJECT Registered blind subjects (n = 49) classified as having light perception or better (n= 19, 12 men, 7 women, aged 23-61 years) or having no conscious perception of light (n=30, 24 men, 6 women, aged 19-72 years) were studied in their normal environment. MEASUREMENT Sequential 4-hourly urine samples (plus an overnight sample) were collected for 48h each week for 3-5 weeks. Urinary cortisol and 6-sulphatoxymelatonin were measured by radioimmunoassay. RESULT: Irrespective of the type of circadian rhythm (entrained or free-running), there was a significant correlation between the characteristics of the 6-sulphatoxymelatonin and cortisol rhythms in the blind subjects. CONCLUSION: Urinary cortisol is recommended as a useful marker of circadian phase in field studies in addition to urinary 6- sulphatoxymelatonin measurements.

Item Type: Article
Authors :
Skene, D.J.
James, K.
Arendt, J.
Date : 1999
DOI : 10.1046/j.1365-2265.1999.00714.x
Uncontrolled Keywords : melatonin derivative, adult, article, blindness, circadian rhythm, clinical article, correlation function, female, human, hydrocortisone release, hydrocortisone urine level, male, priority journal, suprachiasmatic nucleus, Adult, Aged, Biological Markers, Blindness, Circadian Rhythm, Female, Humans, Hydrocortisone, Male, Melatonin, Middle Aged, Regression Analysis
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 02:05
Last Modified : 17 Jun 2020 02:05

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