Visual impairment and circadian rhythm disorders

Lockley, S.W., Arendt, J. and Skene, D.J. (2007) Visual impairment and circadian rhythm disorders Dialogues in Clinical Neuroscience, 9 (3). pp. 301-314.

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Abstract

Many aspects of human physiology and behavior are dominated by 24-hour circadian rhythms that have a major impact on our health and well-being, including the sleep-wake cycle, alertness and performance patterns, and many daily hormone profiles. These rhythms are spontaneously generated by an internal "pacemaker" in the hypothalamus, and daily light exposure to the eyes is required to keep these circadian rhythms synchronized both internally and with the external environment. Sighted individuals take this daily synchronization process for granted, although they experience some of the consequences of circadian desynchrony when "jetlagged" or working night shifts. Most blind people with no perception of light, however, experience continual circadian desynchrony through a failure of light information to reach the hypothalamic circadian clock, resulting in cyclical episodes of poor sleep and daytime dysfunction. Daily melatonin administration, which provides a replacement synchronizing daily "time cue," is a promising therapeutic strategy, although optimal treatment dose and timing remain to be determined. © 2007, LLS SAS.

Item Type:	Article
Authors :	Name Email ORCID Lockley, S.W. s.lockley@surrey.ac.uk Arendt, J. Skene, D.J.
Date :	2007
Uncontrolled Keywords :	Advanced sleep phase syndrome, Alertness, Blindness, Circadian, Delayed sleep phase syndrome, Entrainment, Melatonin, Non-24-hour sleep-wake disorder, Performance, Sleep, melanopsin, melatonin, article, circadian rhythm, circadian rhythm sleep disorder, drug dose comparison, drug dose reduction, drug mechanism, human, hypothalamus, jet lag, light exposure, low drug dose, nonhuman, protein blood level, risk assessment, sleep waking cycle, visual impairment, work schedule, Animals, Central Nervous System Depressants, Chronobiology Disorders, Humans, Melatonin, Vision Disorders
Depositing User :	Clive Harris
Date Deposited :	17 Jun 2020 01:56
Last Modified :	17 Jun 2020 01:56
URI:	http://epubs.surrey.ac.uk/id/eprint/857935

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