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Melatonin Regulation of Circadian Rhythmicity in Vertebrates

Weaver, D.R. and Lockley, S.W. (2009) Melatonin Regulation of Circadian Rhythmicity in Vertebrates In: Encyclopedia of Neuroscience. Elsevier Ltd, pp. 721-732. ISBN 9780080450469 (ISBN)

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Abstract

The pineal hormone, melatonin, influences circadian rhythms in a species-specific manner. Generally, endogenous melatonin is more important for circadian function in nonmammalian vertebrates, whereas in mammals the impact of melatonin is most clearly seen when exogenous melatonin is administered. The effects of melatonin on circadian rhythms in mammals are often subtle. In humans, inconsistency in the effects of melatonin has been reported, and this may be due in part to inconsistency in timing and dose. Rodent studies to identify molecular mechanisms of melatonin action emphasize the role of the MT1 receptor, but some responses appear due to the MT2 receptor subtype. © 2009 Elsevier Ltd All rights reserved.

Item Type: Book Section
Authors :
NameEmailORCID
Weaver, D.R.
Lockley, S.W.s.lockley@surrey.ac.uk
Date : 2009
DOI : 10.1016/B978-008045046-9.01608-9
Uncontrolled Keywords : Behavior, Circadian rhythms, Entrainment, Hormones, Knockout mice, Melatonin, Melatonin receptors, MT1, MT2, Phase shift, Suprachiasmatic nucleus
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:52
Last Modified : 17 Jun 2020 01:52
URI: http://epubs.surrey.ac.uk/id/eprint/857930

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