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Use of transdermal melatonin delivery to improve sleep maintenance during daytime

Aeschbach, D., Lockyer, B.J., Dijk, D.-J., Lockley, S.W., Nuwayser, E.S., Nichols, L.D. and Czeisler, C.A. (2009) Use of transdermal melatonin delivery to improve sleep maintenance during daytime Clinical Pharmacology and Therapeutics, 86 (4). pp. 378-382.

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Abstract

Oral melatonin (MEL) can improve daytime sleep, but the hormone's short elimination half-life limits its use as a hypnotic in shift workers and individuals with jet lag or other sleep problems. Here we show, in healthy subjects, that transdermal delivery of MEL during the daytime can elevate plasma MEL and reduce waking after sleep onset, by promoting sleep in the latter part of an 8-h sleep opportunity. Transdermal MEL may have advantages over fast-release oral MEL in improving sleep maintenance during adverse circadian phases. © 2009 American Society for Clinical Pharmacology and Therapeutics.

Item Type: Article
Authors :
NameEmailORCID
Aeschbach, D.
Lockyer, B.J.
Dijk, D.-J.
Lockley, S.W.s.lockley@surrey.ac.uk
Nuwayser, E.S.
Nichols, L.D.
Czeisler, C.A.
Date : 2009
DOI : 10.1038/clpt.2009.109
Uncontrolled Keywords : melatonin, placebo, adult, alertness, article, attention, circadian rhythm, clinical trial, controlled clinical trial, controlled study, core temperature, crossover procedure, double blind procedure, drug blood level, drug delivery system, drug half life, female, human, male, maximum plasma concentration, normal human, priority journal, randomized controlled trial, REM sleep, sleep, sleep stage, sleep time, sleep waking cycle, slow wave sleep, time to maximum plasma concentration, transdermal patch, Administration, Cutaneous, Adult, Body Temperature, Central Nervous System Depressants, Circadian Rhythm, Cross-Over Studies, Delayed-Action Preparations, Double-Blind Method, Electroencephalography, Female, Half-Life, Humans, Male, Melatonin, Sex Factors, Sleep, Sleep Disorders, Circadian Rhythm
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:47
Last Modified : 17 Jun 2020 01:47
URI: http://epubs.surrey.ac.uk/id/eprint/857922

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