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Total visual blindness is protective against breast cancer

Flynn-Evans, E.E., Stevens, R.G., Tabandeh, H., Schernhammer, E.S. and Lockley, S.W. (2009) Total visual blindness is protective against breast cancer Cancer Causes and Control, 20 (9). pp. 1753-1756.

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Abstract

Objective: Observational data, though sparse and based on small studies with limited ability to control for known breast cancer risk factors, support a lower risk of breast cancer in blind women compared to sighted women. Mechanisms influenced by ocular light perception, such as melatonin or circadian synchronization, are thought to account for this lower risk. Methods: To evaluate whether blind women with no perception of light (NPL) have a lower prevalence of breast cancer compared to blind women with light perception (LP), we surveyed a cohort of 1,392 blind women living in North America (66 breast cancer cases). Results: In multivariate-logistic regression models controlling for breast cancer risk factors, women with NPL had a significantly lower prevalence of breast cancer than women with LP (odds ratio, 0.43; 95% confidence interval, 0.21-0.85). We observed little difference in these associations when restricting to postmenopausal women, non-shift workers or when excluding women diagnosed with breast cancer within 2 or 4 years of onset of blindness. Blind women with NPL appear to have a lower risk of breast cancer, compared to blind women with LP. More research is needed to elucidate the impact of LP on circadian coordination and melatonin production in the blind and how these factors may relate to breast cancer risk.

Item Type: Article
Authors :
NameEmailORCID
Flynn-Evans, E.E.
Stevens, R.G.
Tabandeh, H.
Schernhammer, E.S.
Lockley, S.W.s.lockley@surrey.ac.uk
Date : 2009
DOI : 10.1007/s10552-009-9405-0
Uncontrolled Keywords : Blindness, Breast cancer, Circadian, Light at night, Visual impairment, adult, article, blindness, breast cancer, cancer risk, controlled study, female, human, major clinical study, postmenopause, prevalence, priority journal, risk assessment, work schedule, Blindness, Breast Neoplasms, Female, Humans, Middle Aged, Odds Ratio, Prevalence, Risk Factors
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:47
Last Modified : 17 Jun 2020 01:47
URI: http://epubs.surrey.ac.uk/id/eprint/857921

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