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Melanopsin and Rod-cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans

Gooley, J.J., Mien, I.H., St. Hilaire, M.A., Yeo, S.-C., Chua, E.C.-P., van Reen, E., Hanley, C.J., Hull, J.T., Czeisler, C.A. and Lockley, S.W. (2012) Melanopsin and Rod-cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans Journal of Neuroscience, 32 (41). pp. 14242-14253.

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Abstract

In mammals, the pupillary light reflex is mediated by intrinsically photosensitive melanopsin-containing retinal ganglion cells that also receive input from rod-cone photoreceptors. To assess the relative contribution of melanopsin and rod-cone photoreceptors to the pupillary light reflex in humans, we compared pupillary light responses in normally sighted individuals (n=24) with a blind individual lacking rod-cone function. Here, we show that visual photoreceptors are required for normal pupillary responses to continuous light exposure at low irradiance levels, and for sustained pupillary constriction during exposure to light in the long-wavelength portion of the visual spectrum. In the absence of rod-cone function, pupillomotor responses are slow and sustained, and cannot track intermittent light stimuli, suggesting that rods/cones are required for encoding fast modulations in light intensity. In sighted individuals, papillary constriction decreased monotonically for at least 30 min during exposure to continuous low-irradiance light, indicating that steady-state pupillary responses are an order of magnitude slower than previously reported. Exposure to low-irradiance intermittent green light (543 nm; 0.1-4 Hz) for 30 min, which was given to activate cone photoreceptors repeatedly, elicited sustained pupillary constriction responses that were more than twice as great compared with exposure to continuous green light. Our findings demonstrate nonredundant roles for rod-cone photoreceptors and melanopsin in mediating pupillary responses to continuous light. Moreover, our results suggest that it might be possible to enhance nonvisual light responses to low-irradiance exposures by using intermittent light to activate cone photoreceptors repeatedly in humans. © 2012 the authors.

Item Type: Article
Authors :
NameEmailORCID
Gooley, J.J.
Mien, I.H.
St. Hilaire, M.A.
Yeo, S.-C.
Chua, E.C.-P.
van Reen, E.
Hanley, C.J.
Hull, J.T.
Czeisler, C.A.
Lockley, S.W.s.lockley@surrey.ac.uk
Date : 2012
DOI : 10.1523/JNEUROSCI.1321-12.2012
Uncontrolled Keywords : melanopsin, article, blindness, dark adaptation, female, human, human experiment, light adaptation, light exposure, light intensity, light irradiance, male, normal human, priority journal, pupil, pupil reflex, questionnaire, retina cone, retina rod, spectral sensitivity, visual stimulation, visuomotor coordination, Adaptation, Ocular, Adult, Female, Humans, Male, Middle Aged, Photic Stimulation, Pupil, Reflex, Pupillary, Retinal Cone Photoreceptor Cells, Retinal Rod Photoreceptor Cells, Rod Opsins, Young Adult
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:39
Last Modified : 17 Jun 2020 01:39
URI: http://epubs.surrey.ac.uk/id/eprint/857902

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