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Non-24-h Sleep-Wake Disorder (Free-running Type, Nonentrained Type, Hypernychthemeral Syndrome) in Sighted and Blind Patients

Lockley, S.W. and Uchiyama, M. (2013) Non-24-h Sleep-Wake Disorder (Free-running Type, Nonentrained Type, Hypernychthemeral Syndrome) in Sighted and Blind Patients In: Encyclopedia of Sleep. Elsevier Inc., pp. 34-40. ISBN 9780123786111 (ISBN); 9780123786104 (ISBN)

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Abstract

Non-24-h sleep-wake Disorder (N24HSWD) is a cyclic debilitating circadian rhythm sleep disorder characterized by the inability to sleep on a 24-h schedule. Individuals who are physically or biologically isolated from a normal 24-h light-dark cycle exhibit a sleep-wake cycle that is different from, and usually longer than, 24. h. It is relatively rare in sighted patients and may be associated with delayed sleep phase disorder or psychiatric disorders in some cases. It is much more common in individuals who are totally blind because of the lack of light information reaching the circadian pacemaker in the hypothalamus. We review the clinical characteristics of patients with N24HSWD, discuss the biological mechanisms that may underlie its development, and describe potential treatment strategies. © 2013 Elsevier Inc. All rights reserved.

Item Type: Book Section
Authors :
NameEmailORCID
Lockley, S.W.s.lockley@surrey.ac.uk
Uchiyama, M.
Date : 2013
DOI : 10.1016/B978-0-12-378610-4.00271-0
Uncontrolled Keywords : Blindness, Circadian rhythm sleep disorders, Free-running type, Hypernychthemeral syndrome, Melatonin, Non-24-h sleep-wake disorder, Nonentrained type
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:36
Last Modified : 17 Jun 2020 01:36
URI: http://epubs.surrey.ac.uk/id/eprint/857893

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