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Neurobehavioral performance impairment in insomnia: Relationships with self-reported sleep and daytime functioning

Shekleton, J.A., Flynn-Evans, E.E., Miller, B., Epstein, L.J., Kirsch, D., Brogna, L.A., Burke, L.M., Bremer, E., Murray, J.M., Gehrman, P. , Lockley, S.W. and Rajaratnam, S.M.W. (2014) Neurobehavioral performance impairment in insomnia: Relationships with self-reported sleep and daytime functioning Sleep, 37 (1). pp. 107-116.

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Abstract

Study Objectives: Despite the high prevalence of insomnia, daytime consequences of the disorder are poorly characterized. This study aimed to identify neurobehavioral impairments associated with insomnia, and to investigate relationships between these impairments and subjective ratings of sleep and daytime dysfunction. Design: Cross-sectional, multicenter study. Setting: Three sleep laboratories in the USA and Australia. Patients: Seventy-six individuals who met the Research Diagnostic Criteria (RDC) for Primary Insomnia, Psychophysiological Insomnia, Paradoxical Insomnia, and/or Idiopathic Childhood Insomnia (44F, 35.8 ± 12.0 years [mean ± SD]) and 20 healthy controls (14F, 34.8 ± 12.1 years). Interventions: N/A. Measurements and Results: Participants completed a 7-day sleep-wake diary, questionnaires assessing daytime dysfunction, and a neurobehavioral test battery every 60-180 minutes during an afternoon/evening sleep laboratory visit. Included were tasks assessing sustained /and switching attention, working memory, subjective sleepiness, and effort. Switching attention and working memory were significantly worse in insomnia patients than controls, while no differences were found for simple or complex sustained attention tasks. Poorer sustained attention in the control, but not the insomnia group, was significantly associated with increased subjective sleepiness. In insomnia patients, poorer sustained attention performance was associated with reduced health-related quality of life and increased insomnia severity. Conclusions: We found that insomnia patients exhibit deficits in higher level neurobehavioral functioning, but not in basic attention. The findings indicate that neurobehavioral deficits in insomnia are due to neurobiological alterations, rather than sleepiness resulting from chronic sleep deficiency.

Item Type: Article
Authors :
NameEmailORCID
Shekleton, J.A.
Flynn-Evans, E.E.
Miller, B.
Epstein, L.J.
Kirsch, D.
Brogna, L.A.
Burke, L.M.
Bremer, E.
Murray, J.M.
Gehrman, P.
Lockley, S.W.s.lockley@surrey.ac.uk
Rajaratnam, S.M.W.
Date : 2014
DOI : 10.5665/sleep.3318
Uncontrolled Keywords : Cognitive performance, Depression, Fatigue, Functional impairment, Insomnia, Sleep, Sleepiness, adult, aged, article, attention, behavior disorder, cognition, controlled study, cross-sectional study, daytime somnolence, exercise, experimental cognitive test, female, functional disease, health behavior, human, idiopathic childhood insomnia, idiopathic disease, insomnia, major clinical study, male, middle aged, multicenter study, neurobehavioral performance impairment, night sleep, paradoxical insomnia, primary insomnia, priority journal, psychophysiological insomnia, quality of life, questionnaire, Research Diagnostic Criteria, self report, sleep, sleep time, somnolence, working memory, cognitive performance, depression, fatigue, functional impairment, Insomnia, sleep, sleepiness, Adolescent, Adult, Aged, Attention, Australia, Cognition, Cross-Sectional Studies, Depression, Female, Humans, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Questionnaires, Self Report, Sleep, Sleep Initiation and Maintenance Disorders, Sleep Stages, Time Factors, United States, Wakefulness, Young Adult
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:24
Last Modified : 17 Jun 2020 01:24
URI: http://epubs.surrey.ac.uk/id/eprint/857881

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