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Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans

Rahman, S.A., Castanon-Cervantes, O., Scheer, F.A.J.L., Shea, S.A., Czeisler, C.A., Davidson, A.J. and Lockley, S.W. (2015) Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans Brain, Behavior, and Immunity, 47. pp. 4-13.

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Abstract

Various aspects of immune response exhibit 24-h variations suggesting that infection susceptibility and treatment efficacy may vary by time of day. Whether these 24-h variations are endogenous or evoked by changes in environmental or behavioral conditions is not known. We assessed the endogenous circadian control and environmental and behavioral influences on ex-vivo lipopolysaccharide stimulation of whole blood in thirteen healthy participants under 48. h of baseline conditions with standard sleep-wake schedules and 40-50. h of constant environmental and behavioral (constant routine; CR) conditions. Significant 24-h rhythms were observed under baseline conditions in Monocyte Chemotactic Protein, Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin 8 but not Tumor Necrosis Factor alpha whereas significant 24-h rhythms were observed in all four immune factors under CR conditions. The rhythm amplitudes, expressed as a percentage of mean, were comparable between immune factors and across conditions. In contrast, the acrophase time (time of the fitted peak) was different between immune factors, and included daytime and nighttime peaks and changes across behavioral conditions. These results suggest that the endogenous circadian system underpins the temporal organization of immune responses in humans with additional effects of external environmental and behavioral cycles. These findings have implications for understanding the adverse effects of recurrent circadian disruption and sleep curtailment on immune function. © 2014 Elsevier Inc..

Item Type: Article
Authors :
NameEmailORCID
Rahman, S.A.
Castanon-Cervantes, O.
Scheer, F.A.J.L.
Shea, S.A.
Czeisler, C.A.
Davidson, A.J.
Lockley, S.W.s.lockley@surrey.ac.uk
Date : 2015
DOI : 10.1016/j.bbi.2014.11.003
Uncontrolled Keywords : Chemokine, Circadian, Cytokine, Human, Immune response, Lipopolysaccharide, Melatonin, Sleep, bacterium lipopolysaccharide, chemokine, cytokine, granulocyte macrophage colony stimulating factor, interleukin 8, monocyte chemotactic protein, tumor necrosis factor alpha, granulocyte macrophage colony stimulating factor, interleukin 8, lipopolysaccharide, monocyte chemotactic protein 1, tumor necrosis factor, adult, adverse drug reaction, Article, behavior, circadian rhythm, environmental factor, evoked response, female, human, human experiment, immune response, male, neurobiology, night, normal human, priority journal, protein expression, regulatory mechanism, sleep waking cycle, blood, circadian rhythm, drug effects, physiology, young adult, Adult, Chemokine CCL2, Circadian Rhythm, Female, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Interleukin-8, Lipopolysaccharides, Male, Tumor Necrosis Factor-alpha, Young Adult
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:18
Last Modified : 17 Jun 2020 01:18
URI: http://epubs.surrey.ac.uk/id/eprint/857872

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