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Non-24-hour sleep-wake rhythm disorder in sighted and blind patients

Uchiyama, M. and Lockley, S.W. (2015) Non-24-hour sleep-wake rhythm disorder in sighted and blind patients Sleep Medicine Clinics, 10 (4). pp. 495-516.

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Non-24-hour sleep-wake rhythm disorder (N24SWD) is a cyclic debilitating circadian rhythm sleep disorder characterized by an inability to sleep on a 24-hour schedule. Individuals isolated from a 24-hour light-dark cycle exhibit sleep-wake cycles different from 24 hours. Relatively rare in sighted patients, it may be associated with delayed sleep-wake rhythm disorder or psychiatric disorders. It is more common in totally blind individuals owing to the lack of light information reaching the circadian pacemaker in the hypothalamus. We review the clinical characteristics of patients with N24SWD, discuss the biological mechanisms that may underlie its development, and describe treatment strategies. © 2015 Elsevier Inc.

Item Type: Article
Authors :
Uchiyama, M.
Date : 2015
DOI : 10.1016/j.jsmc.2015.07.006
Uncontrolled Keywords : Blindness, Circadian rhythm sleep disorders, Free-running type, Hypernychthemeral syndrome, Melatonin, Non-24-hour sleep-wake rhythm disorder, Nonentrained type, caffeine, cyanocobalamin, mecobalamin, melatonin, modafinil, placebo, ramelteon, tasimelteon, triazolam, Article, blindness, circadian rhythm, clinical assessment, clinical feature, disease association, food and drug administration, human, hypnosis, mental disease, multicenter study (topic), non twenty four hour sleep wake rhythm disorder, pathogenesis, phase 3 clinical trial (topic), photoactivation, phototherapy, priority journal, randomized controlled trial (topic), sleep, sleep disorder, sleep waking cycle, vision, blindness, complication, genetics, pathophysiology, Sleep Disorders, Circadian Rhythm, Blindness, Humans, Sleep Disorders, Circadian Rhythm
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 01:15
Last Modified : 17 Jun 2020 01:15

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