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A unified model of melatonin, 6-sulfatoxymelatonin, and sleep dynamics

Abeysuriya, R.G., Lockley, S.W., Robinson, P.A. and Postnova, S. (2018) A unified model of melatonin, 6-sulfatoxymelatonin, and sleep dynamics Journal of Pineal Research, 64 (4).

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Abstract

A biophysical model of the key aspects of melatonin synthesis and excretion has been developed, which is able to predict experimental dynamics of melatonin in plasma and saliva, and of its urinary metabolite 6-sulfatoxymelatonin (aMT6s). This new model is coupled to an established model of arousal dynamics, which predicts sleep and circadian dynamics based on light exposure and times of wakefulness. The combined model thus predicts melatonin levels over the sleep-wake/dark-light cycle and enables prediction of melatonin-based circadian phase markers, such as dim light melatonin onset (DLMO) and aMT6s acrophase under conditions of normal sleep and circadian misalignment. The model is calibrated and tested against group average data from 10 published experimental studies and is found to reproduce quantitatively the key dynamics of melatonin and aMT6s, including the timing of release and amplitude, as well as response to controlled lighting and shift work. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Item Type: Article
Authors :
NameEmailORCID
Abeysuriya, R.G.
Lockley, S.W.s.lockley@surrey.ac.uk
Robinson, P.A.
Postnova, S.
Date : 2018
DOI : 10.1111/jpi.12474
Uncontrolled Keywords : 6-sulfatoxymelatonin, circadian, dim light melatonin onset, melatonin, pineal, sleep, 6 hydroxymelatonin o sulfate, melatonin, 6-sulfatoxymelatonin, melatonin, arousal, Article, calculation, circadian rhythm, equilibrium constant, human, light, light dark cycle, mathematical analysis, mathematical parameters, plasma, protein blood level, protein synthesis, quantitative analysis, saliva, saliva analysis, shift work, sleep pattern, sleep waking cycle, urinalysis, urine, analogs and derivatives, biological model, metabolism, physiology, sleep, Circadian Rhythm, Humans, Melatonin, Models, Biological, Sleep
Depositing User : Clive Harris
Date Deposited : 17 Jun 2020 00:56
Last Modified : 17 Jun 2020 00:56
URI: http://epubs.surrey.ac.uk/id/eprint/857835

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