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Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study

Thacher, Jesse D., Poulsen, Aslak H., Roswall, Nina, Hvidtfeldt, Ulla, Raaschou-Nielsen, Ole, Solvang Jensen, Steen, Ketzel, Matthias, Brandt, Jorgen, Overvad, Kim, Tjonneland, Anne , Munzel, Thomas and Sorensen, Mette (2020) Road Traffic Noise Exposure and Filled Prescriptions for Antihypertensive Medication: A Danish Cohort Study Environmental Health Perspectives, 128 (5).

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Abstract

Background: Epidemiological research on effects of transportation noise on incident hypertension is inconsistent. Objectives: We aimed to investigate whether residential road traffic noise increases the risk for hypertension. Methods: In a population-based cohort of 57,053 individuals 50–64 years of age at enrollment, we identified 21,241 individuals who fulfilled our case definition of filling ≥2 prescriptions and ≥180 defined daily doses of antihypertensive drugs (AHTs) within a year, during a mean follow-up time of 14.0 y. Residential addresses from 1987 to 2016 were obtained from national registers, and road traffic noise at the most exposed façade as well as the least exposed façade was modeled for all addresses. Analyses were conducted using Cox proportional hazards models. Results: We found no associations between the 10-y mean exposure to road traffic noise and filled prescriptions for AHTs, with incidence rate ratios (IRRs) of 0.999 [95% confidence intervals (CI): 0.980, 1.019)] per 10-dB increase in road traffic noise at the most exposed façade and of 1.001 (95% CI: 0.977, 1.026) at the least exposed façade. Interaction analyses suggested an association with road traffic noise at the least exposed façade among subpopulations of current smokers and obese individuals. Conclusion: The present study does not support an association between road traffic noise and filled prescriptions for AHTs. https://doi.org/10.1289/EHP6273

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Civil and Environmental Engineering
Authors :
NameEmailORCID
Thacher, Jesse D.
Poulsen, Aslak H.
Roswall, Nina
Hvidtfeldt, Ulla
Raaschou-Nielsen, Ole
Solvang Jensen, Steen
Ketzel, Matthiasm.ketzel@surrey.ac.uk
Brandt, Jorgen
Overvad, Kim
Tjonneland, Anne
Munzel, Thomas
Sorensen, Mette
Date : 14 May 2020
Funders : Independent Research Fund Denmark
DOI : 10.1289/EHP6273
Copyright Disclaimer : Copyrighted to the authors.
Depositing User : James Marshall
Date Deposited : 28 May 2020 15:38
Last Modified : 28 May 2020 15:38
URI: http://epubs.surrey.ac.uk/id/eprint/856996

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