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Bovistol B, bovistol D and strossmayerin: Sesquiterpene metabolites from the culture filtrate of the basidiomycete Coprinopsis strossmayeri

Banks, Alice, Song, Lijang, Challis, Gregory L., Bailey, Andrew and Foster, Gary D. (2020) Bovistol B, bovistol D and strossmayerin: Sesquiterpene metabolites from the culture filtrate of the basidiomycete Coprinopsis strossmayeri Plos One, 15 (4).

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Abstract

Basidiomycete fungi are a rich source of natural products with a diverse array of potentially exploitable bioactivities. Two dimeric sesquiterpenes, bovistol B (1) and D (2), and one monomeric sesquiterpene, strossmayerin (7), were isolated from the culture filtrate of the basidiomycete fungus Coprinopsis strossmayeri. The structures were determined through a combination of MS and 1D/2D NMR spectroscopic techniques. Likely monomeric precursors, identified on the basis of HRMS analysis, allow a plausible biosynthetic pathway to be proposed for the biosynthesis of 1 and 2, involving the dimerisation of the monomer through a hetero-Diels-Alder mechanism. A gene cluster, including a putative sesquiterpene 1–11 cyclase, was identified through phylogenetic and RNA-seq analysis, and is proposed to be responsible for the biosynthesis of 1 and 2.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Banks, Alicealice.banks@surrey.ac.uk
Song, Lijang
Challis, Gregory L.
Bailey, Andrewandrew.bailey@surrey.ac.uk
Foster, Gary D.
Date : 6 April 2020
Funders : EPSRC, Biotechnology and Biological Sciences Research Council (BBSRC)
DOI : 10.1371/journal.pone.0229925
Grant Title : EPSRC Grant
Copyright Disclaimer : © 2020 Banks et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Depositing User : James Marshall
Date Deposited : 07 Apr 2020 11:25
Last Modified : 07 Apr 2020 11:25
URI: http://epubs.surrey.ac.uk/id/eprint/854132

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