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Investigation of drug-release polymers using nuclear reaction analysis and particle induced X-ray emission

Smith, Richard, Massingham, Gary and Clough, Anthony (2003) Investigation of drug-release polymers using nuclear reaction analysis and particle induced X-ray emission Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 505 (1-2). pp. 582-585.

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Abstract

The diffusion of water into the developmental drug-release polymer addition cured silicone has been investigated using {sup 3}He ion scanning micro-beam techniques developed at the University of Surrey. Polymer samples loaded with 15% by weight of the drug chlorohexidine diacetate were immersed in a water based phosphate buffered saline solution for times of 1 hour, 1 day, 1 week and 1 month. The results showed that as the water diffused into the polymer it associated with the drug allowing its release by diffusion through the network formed by water filled pores. Future improvements to the techniques are discussed including the use of an array of CdZnTe detectors.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
NameEmailORCID
Smith, Richardr.w.smith@surrey.ac.uk
Massingham, Gary
Clough, AnthonyA.Clough@surrey.ac.uk
Date : 29 March 2003
DOI : 10.1016/S0168-9002(03)01152-5
Copyright Disclaimer : © 2003 Elsevier Science B.V. All rights reserved.
Depositing User : James Marshall
Date Deposited : 23 Mar 2020 16:19
Last Modified : 23 Mar 2020 16:19
URI: http://epubs.surrey.ac.uk/id/eprint/854074

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