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Simulation of cellular irradiation with the CENBG microbeam line using GEANT4

Incerti, S., Barberet, P., Villeneuve, R., Aguer, P., Gontier, E., Michelet-Habchi, C., Moretto, P., Nguyen, D.T, Pouthier, T. and Smith, Richard (2004) Simulation of cellular irradiation with the CENBG microbeam line using GEANT4 IEEE Transactions on Nuclear Science.

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Abstract

Light-ion microbeams provide a unique opportunity to irradiate biological samples at the cellular level and to investigate radiobiological effects at low doses of high linear energy transfer ionizing radiation. Since 1998 a single-ion irradiation facility has been developed on the focused horizontal microbeam line of the CENBG 3.5 MV Van de Graaff accelerator. This setup delivers in air single protons and alpha particles of a few MeV onto cultured cells, with a spatial resolution of a few micrometers, allowing subcellular targeting. In this paper, we present results from the use of the GEANT4 toolkit to simulate cellular irradiation with the CENBG microbeam line, from the entrance to the microprobe up to the cellular medium. We show that a 3 MeV incident alpha particle may deliver a dose of 0.33 Gy to a typical cell nucleus.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
NameEmailORCID
Incerti, S.
Barberet, P.
Villeneuve, R.
Aguer, P.
Gontier, E.
Michelet-Habchi, C.
Moretto, P.
Nguyen, D.T
Pouthier, T.
Smith, Richardr.w.smith@surrey.ac.uk
Date : 16 August 2004
DOI : https://doi.org/10.1109/TNS.2004.832224
OA Location : https://ieeexplore.ieee.org/document/1323703
Uncontrolled Keywords : Object oriented modeling, Collimators, Magnetic flux, Biological system modeling, Ionizing radiation, Alpha particles, Monte Carlo methods, Protons, Spatial resolution, Humans
Depositing User : James Marshall
Date Deposited : 23 Mar 2020 13:50
Last Modified : 23 Mar 2020 13:50
URI: http://epubs.surrey.ac.uk/id/eprint/854071

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