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Angiogenesis in Tissue Engineering: As Nature Intended?

Mastrullo, Valeria, Cathery, William, Velliou, Eirini, Madeddu, Paolo and Campagnolo, Paola (2020) Angiogenesis in Tissue Engineering: As Nature Intended? Frontiers in Bioengineering and Biotechnology.

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Abstract

Despite the steady increase in the number of studies focusing on the development of tissue engineered constructs, solutions delivered to the clinic are still limited. Specifically, the lack of mature and functional vasculature greatly limits the size and complexity of vascular scaffold models. If tissue engineering aims to replace large portions of tissue with the intention of repairing significant defects, a more thorough understanding of the mechanisms and players regulating the angiogenic process is required in the field. This review will present the current material and technological advancements addressing the imperfect formation of mature blood vessels within tissue engineered structures.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Mastrullo, Valeriav.mastrullo@surrey.ac.uk
Cathery, William
Velliou, Eirinie.velliou@surrey.ac.uk
Madeddu, Paolo
Campagnolo, Paolap.campagnolo@surrey.ac.uk
Date : 20 March 2020
Funders : University of Surrey Doctoral College, Department of Chemical and Process Engineering, FEPS, University of Surrey, Heart Research UK, National Centre for the Replacement, Refinement & Reduction of Animals
DOI : 10.3389/fbioe.2020.00188
Grant Title : Heart Research UK grant
Copyright Disclaimer : Copyright © 2020 Mastrullo, Cathery, Velliou,Madeddu and Campagnolo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Contributors :
ContributionNameEmailORCID
http://www.loc.gov/loc.terms/relators/EDTCancedda, Ranieri
Uncontrolled Keywords : scaffolds, spatio-temporal gradient, vessel maturation, angiogenesis, tissue engineering
Depositing User : James Marshall
Date Deposited : 23 Mar 2020 10:30
Last Modified : 23 Mar 2020 15:21
URI: http://epubs.surrey.ac.uk/id/eprint/854068

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