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3D imaging of microscopic structures using a proton beam

Michelet-Habchi, C., Incerti, S., Aguer, P., Barberet, Ph, Gontier, E., Guinefolleau, T., Moretto, Ph, Pouthier, A. and Smith, Richard (2005) 3D imaging of microscopic structures using a proton beam IEEE Transactions on Nuclear Science, 52 (3). pp. 612-617.

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Abstract

The use of a 1/spl mu/m ion beam as a tomographic probe could constitute a powerful tool for displaying the 3D structure of samples a few tens or hundreds of micrometers thick in a nondestructive way. At the Centre d'Etudes Nucle/spl acute/aires de Bordeaux-Gradignan (CENBG), Gradignan, France, ion beam microtomography has been developed for biomedical applications at the cell level. The internal structure of cancer cells has been explored using scanning transmission ion microscopy (STIM) tomography, giving access to the 3D distribution of mass density (in g/cm/sup 3/) within the analyzed volume. The sole sample preparation required is cryofixation and freeze-drying, permitting under vacuum analysis. The combination of STIM and particle induced X-ray emission (PIXE) tomography is under progress with the aim of revealing the distributions and local concentrations of elements at the cell level.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors :
NameEmailORCID
Michelet-Habchi, C.
Incerti, S.
Aguer, P.
Barberet, Ph
Gontier, E.
Guinefolleau, T.
Moretto, Ph
Pouthier, A.
Smith, Richardr.w.smith@surrey.ac.uk
Date : 25 July 2005
DOI : 10.1109/TNS.2005.851411
Copyright Disclaimer : Copyright © 2005, IEEE
Depositing User : James Marshall
Date Deposited : 20 Mar 2020 16:42
Last Modified : 20 Mar 2020 16:44
URI: http://epubs.surrey.ac.uk/id/eprint/854064

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