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The degradation of polyglycolide in water and deuterium oxide. Part II: Nuclear reaction analysis and magnetic resonance imaging of water distribution

Milroy, G.E., Smith, R.W., Hollands, R., Clough, A.S., Mantle, M.D., Gladden, L.F., Huatan, H. and Cameron, R.E. (2003) The degradation of polyglycolide in water and deuterium oxide. Part II: Nuclear reaction analysis and magnetic resonance imaging of water distribution Polymer, 44 (5). pp. 1425-1435.

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Abstract

Magnetic resonance imaging (MRI) and scanning microbeam nuclear reaction analysis (NRA) were used to monitor changes of water ingress into polyglycolide (PGA) disks with degradation time. MRI detects H2O, whereas NRA is sensitive to D2O. The acid-catalysed hydrolysis of the ester is significantly slower in D2O than H2O because of the kinetic isotope effect. This behaviour was investigated in Part I. In this paper, NRA was used to investigate PGA hydration in buffers made from D2O, and NRA and MRI experiments were performed on samples degraded buffers made from a 50% mixture of D2O and H2O (D2O/H2O 50:50) to allow a comparison between the two techniques. The NRA and MRI results provide direct evidence in support of the four-stage reaction - erosion model reported in previous literature, and show that this model applies to polymer degradation in heavy water and in a buffer made from D2O/H2O 50:50. It is believed that this is the first time that NRA and MRI have been compared for the same hydrating system. © 2002 Elsevier Science Ltd. All rights reserved.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors : Milroy, G.E., Smith, R.W., Hollands, R., Clough, A.S., Mantle, M.D., Gladden, L.F., Huatan, H. and Cameron, R.E.
Date : 21 January 2003
DOI : 10.1016/S0032-3861(02)00884-4
Uncontrolled Keywords : Magnetic resonance imaging, Poly(glycolic acid), Polyglycolide, Degradation, Esters, Heavy water, Hydrolysis, Magnetic resonance imaging, Saline water, Nuclear reaction analysis, Organic polymers, buffer, deuterium oxide, polyglycolide, water, Degradation, Deuterium, Magnetic resonance imaging, polymer, Water, water distribution, article, catalysis, degradation, hydration, kinetics, nuclear magnetic resonance imaging, reaction analysis, water supply
Additional Information : Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - Polymer [Field not mapped to EPrints] AD - Department of Materials Science, Cambridge Ctr. for Med. Materials, University of Cambridge, Pembroke Street, Cambridge CB2 3QZ, United Kingdom [Field not mapped to EPrints] AD - Department of Physics, Sch. of Electronics/Phys. Sci., University of Surrey, Guildford GU2 7XH, United Kingdom [Field not mapped to EPrints] AD - Department of Chemical Engineering, University of Cambridge, Pembroke Street, Cambridge CB2 3RA, United Kingdom [Field not mapped to EPrints] AD - Pfizer Ltd., Pharmaceutical R and D, Sandwich, Kent CT13 9NJ, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] M3 - Article [Field not mapped to EPrints]
Depositing User : James Marshall
Date Deposited : 19 Mar 2020 16:40
Last Modified : 19 Mar 2020 16:40
URI: http://epubs.surrey.ac.uk/id/eprint/854040

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