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Depth Profiling of Small Molecule Ingress into Planar and Cylindrical Materials Using NRA and PIXE

Smith, R.W., Massingham, G. and Clough, A.S. (2003) Depth Profiling of Small Molecule Ingress into Planar and Cylindrical Materials Using NRA and PIXE pp. 478-481.

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Abstract

The use of a 3He ion micro-beam technique to study the ingress/diffusion of water into a planar fibre optic grade glass and a cylindrical drug-release polymer is described. One-dimensional concentration profiles showing the depth of water ingress were produced. The depth of penetration of water into the glass was measured by fitting a Gaussian function to the concentration profile. The ingress of water into the drug-release polymer was found to be Fickian and a cylindrical diffusion model used to obtain a diffusion coefficient. © 2003 American Institute of Physics.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering
Authors : Smith, R.W., Massingham, G. and Clough, A.S.
Date : 13 October 2003
DOI : 10.1063/1.1619763
Uncontrolled Keywords : Controlled drug delivery, Depth profiling, Diffusion, Glass, Industrial research, Targeted drug delivery, Concentration profiles, Diffusion model, Drug release, Gaussian functions, Micro beams, Small molecules, Water ingress, Drug delivery
Additional Information : Unmapped bibliographic data: LA - English [Field not mapped to EPrints] J2 - AIP Conf. Proc. [Field not mapped to EPrints] AD - Department of Physics, University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom [Field not mapped to EPrints] DB - Scopus [Field not mapped to EPrints] M3 - Conference Paper [Field not mapped to EPrints] C3 - AIP Conference Proceedings [Field not mapped to EPrints]
Depositing User : James Marshall
Date Deposited : 19 Mar 2020 16:29
Last Modified : 23 Mar 2020 14:20
URI: http://epubs.surrey.ac.uk/id/eprint/854037

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